Christopher John Saranko
Works (3)
Updated: July 5th, 2023 16:03
2001 journal article
Lung-specific mutagenicity and mutational spectrum in B6C3F1 lacI transgenic mice following inhalation exposure to 1,2-epoxybutene
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 473(1), 37–49.
author keywords: lung-specific mutagenicity; mutational spectrum; B6C3F1 lacI transgenic mice
MeSH headings : Administration, Inhalation; Animals; Bacterial Proteins / drug effects; Bacterial Proteins / genetics; Bone Marrow / metabolism; DNA Mutational Analysis; Epoxy Compounds / administration & dosage; Epoxy Compounds / toxicity; Escherichia coli Proteins; Female; Lac Repressors; Lung / metabolism; Mice; Mice, Transgenic; Mutagenesis / drug effects; Mutagenesis / genetics; Mutagens / administration & dosage; Mutagens / toxicity; Repressor Proteins / drug effects; Repressor Proteins / genetics; Spleen / metabolism; Tissue Distribution
TL;DR:
It is hypothesized that the direct in vivo mutagenicity and further in situ metabolism of EB in the lungs of EB-exposed mice played a prominent role in the generation of the current mutational spectrum.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Butadiene metabolite, 1,2:3,4-diepoxybutane, induces micronuclei but is only weekly mutagenic at lacI in the Big Blue(R) Rat2 lacI transgenic cell line
Environmental and Molecular Mutagenesis, 31(1), 32–40.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Molecular analysis of lacI mutants from transgenic fibroblasts exposed to 1,2-epoxybutene
CARCINOGENESIS, 19(11), 1879–1887.
MeSH headings : Animals; Bacterial Proteins / genetics; Epoxy Compounds / toxicity; Escherichia coli Proteins; Fibroblasts; Lac Repressors; Mice; Mutagens / toxicity; Mutation; Rats; Repressor Proteins / genetics; Transfection
TL;DR:
The mutagenicity and mutational spectrum of EB in Rat2 lacI transgenic fibroblasts are determined and suggest that EB causes mutation primarily by base substitution and that the spectrum of these mutations closely resembles that of BD.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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