Shira Fruchtman

Works (6)

Updated: July 5th, 2023 16:02

2002 journal article

Characterization of pituitary IGF-I receptors: modulation of prolactin and growth hormone

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 283(2), R468–R476.

By: S. Fruchtman n, D. McVey* & R. Borski n

author keywords: signal transduction; teleost; insulin-like growth factor binding proteins; Morone; secretion
MeSH headings : Animals; Bass; Binding, Competitive / drug effects; Crosses, Genetic; Dose-Response Relationship, Drug; Growth Hormone / analysis; Growth Hormone / biosynthesis; Immunohistochemistry; In Vitro Techniques; Insulin / pharmacokinetics; Insulin-Like Growth Factor Binding Proteins / metabolism; Insulin-Like Growth Factor I / pharmacokinetics; Insulin-Like Growth Factor II / pharmacokinetics; Peptide Fragments / pharmacokinetics; Pituitary Gland / chemistry; Pituitary Gland / cytology; Pituitary Gland / drug effects; Pituitary Gland / metabolism; Prolactin / analysis; Prolactin / biosynthesis; Radioligand Assay; Receptor, IGF Type 1 / chemistry; Receptor, IGF Type 1 / metabolism; Substrate Specificity
TL;DR: These results are the first to localize IGF-I receptors to PRL cells, correlate IGF- I binding to its efficacy in regulating GH and PRL secretion, as well as demonstrate that IGFBPs may play a significant role in modulating the disparate actions of IGF-i on PRL and GH secretion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 article

Signal transduction mechanisms mediating rapid, nongenomic effects of cortisol on prolactin release

Borski, R. J., Hyde, G. N., & Fruchtman, S. (2002, May). STEROIDS, Vol. 67, pp. 539–548.

By: R. Borski n, G. Hyde n & S. Fruchtman n

author keywords: steroid hormone; adenylyl cyclase; calcium; cAMP; nongenomic action; phospholipase C; membrane receptor
MeSH headings : Animals; Calcium / metabolism; Cell Membrane / drug effects; Cell Membrane / metabolism; Cells, Cultured; Cyclic AMP / metabolism; Hydrocortisone / pharmacology; Models, Biological; Osmolar Concentration; Pituitary Gland / cytology; Pituitary Gland / drug effects; Pituitary Gland / metabolism; Prolactin / metabolism; Second Messenger Systems / drug effects; Second Messenger Systems / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Tilapia
TL;DR: Findings indicate that the acute inhibitory effects of cortisol on PRL release occur through a nongenomic mechanism involving interactions with the plasma membrane and inhibition of both the Ca(2+) and cAMP signal transduction pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 article

Cortisol suppresses prolactin release through a non-genomic mechanism involving interactions with the plasma membrane

Borski, R. J., Hyde, G. N., Fruchtman, S., & Tsai, W. S. (2001, June). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, Vol. 129, pp. 533–541.

By: R. Borski n, G. Hyde n, S. Fruchtman n & W. Tsai n

author keywords: BSA-conjugated steroid; osmoregulation; pituitary; receptors; calcium; cAMP; cycloheximide; tilapia; hydrocortisone; glucocorticoid
MeSH headings : Animals; Cell Membrane / drug effects; Cell Membrane / metabolism; Cycloheximide / pharmacology; Hydrocortisone / analogs & derivatives; Hydrocortisone / pharmacology; Male; Pituitary Gland / cytology; Pituitary Gland / drug effects; Pituitary Gland / metabolism; Prolactin / metabolism; Tilapia / metabolism
TL;DR: It is suggested that cortisol inhibits PRL release through a plasma membrane-associated, protein-synthesis independent (non-genomic) pathway. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2001 article

Insulin-like growth factor-I augments prolactin and inhibits growth hormone release through distinct as well as overlapping cellular signaling pathways

Fruchtman, S., Gift, B., Howes, B., & Borski, R. (2001, June). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, Vol. 129, pp. 237–242.

By: S. Fruchtman n, B. Gift n, B. Howes n & R. Borski n

author keywords: mitogen-activated protein kinase; phosphatidylinositol 3-kinase; IGF-I signal transduction; IGF-I receptor; LY294002; PD98059; rapamycin; pituitary; teleost
MeSH headings : Animals; Bass / physiology; Chromones / pharmacology; Flavonoids / pharmacology; Growth Hormone / metabolism; Insulin-Like Growth Factor I / metabolism; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Morpholines / pharmacology; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Prolactin / metabolism; Signal Transduction / drug effects; Sirolimus / pharmacology
TL;DR: The studies suggest IGF-I disparately alters PRL and GH by activating distinct as well as overlapping signaling pathways central for mediating actions of growth factors on secretory activity aswell as cell proliferation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Insulin-like growth factor I disparately regulates prolactin and growth hormone synthesis and secretion: Studies using the teleost pituitary model

ENDOCRINOLOGY, 141(8), 2886–2894.

By: S. Fruchtman n, L. Jackson & R. Borski

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Purification, characterization, and bioassay of prolactin and growth hormone from temperate basses, genus Morone

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 117(1), 138–150.

By: L. Jackson n, P. Swanson *, C. Duan *, S. Fruchtman n & C. Sullivan n

author keywords: prolactin; growth hormone; temperate basses
MeSH headings : Amino Acid Sequence; Animals; Bass / metabolism; Biological Assay; Fishes; Growth Hormone / chemistry; Growth Hormone / isolation & purification; Growth Hormone / pharmacology; Hypophysectomy; Insulin-Like Growth Factor I / genetics; Liver / drug effects; Liver / metabolism; Molecular Sequence Data; Oncorhynchus kisutch; Pituitary Gland / chemistry; Prolactin / chemistry; Prolactin / isolation & purification; Prolactin / pharmacology; RNA, Messenger / metabolism; Sequence Alignment; Sodium / blood; Species Specificity
TL;DR: In vivo bioassay, involving hypophysectomy of hybrid striped bass and treatment of the fish maintained in fresh water with homologous PRL, confirmed that the purified striped bass PRL was also bioactive and biological activity of striped bass GH II was confirmed using a heterologous in vitro assay of insulin-like growth factor I mRNA production by coho salmon hepatocytes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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