Works (1)
Updated: July 5th, 2023 16:00
2001 journal article
Efficient assessment of modified nucleoside stability under conditions of automated oligonucleotide synthesis: Characterization of the oxidation and oxidative desulfurization of 2-thiouridine
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 20(10-11), 1871–1879.
MeSH headings : Acetonitriles / chemistry; Carbon Tetrachloride / chemistry; Chromatography, High Pressure Liquid; Hydrogen Peroxide / chemistry; Models, Chemical; Nucleic Acid Denaturation; Oligonucleotides / chemical synthesis; Oligonucleotides / chemistry; Oxygen / metabolism; Sulfur / chemistry; Thiouridine / analogs & derivatives; Thiouridine / chemistry; Time Factors
TL;DR:
A scheme in which the modified nucleoside, directly attached to a solid support, is exposed to the cyclic chemistry of the instrument, and stability of 2-thiouridine against different oxidizers was investigated.
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