Works (7)
Updated: July 5th, 2023 16:00
2007 journal article
Transitin, a nestin-like intermediate filament protein, mediates cortical localization and the lateral transport of Numb in mitotic avian neuroepithelial cells
Development (Cambridge, England), 134(13), 2425–2433.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Embryonic synthesis of the inner limiting membrane and vitreous body
Investigative Ophthalmology and Visual Science, 46(6), 2202–2209.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
Agrin is a chimeric proteoglycan with the attachment sites for heparan sulfate/chondroitin sulfate located in two multiple serine-glycine clusters
JOURNAL OF BIOLOGICAL CHEMISTRY, 278(32), 30106–30114.
MeSH headings : Agrin / chemistry; Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Chickens; Chondroitin Sulfates / chemistry; Electrophoresis, Polyacrylamide Gel; Glycine / chemistry; Glycosylation; Heparitin Sulfate / chemistry; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptides / chemistry; Plasmids / metabolism; Protein Structure, Tertiary; Proteoglycans / chemistry; Recombinant Proteins / chemistry; Sequence Homology, Amino Acid; Serine / chemistry; Threonine / chemistry
TL;DR:
It was found that recombinant and in vivo-derived full-length agrin are not exclusively heparan sulfate proteoglycans but also carry chondroitin sulfate side chains.
(via Semantic Scholar)
www.jbc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Expression of collagen XVIII and localization of its glycosaminoglycan attachment sites
Journal of Biological Chemistry, 278(3), 1700–1707.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
The heparan sulfate proteoglycan agrin modulates neurite outgrowth mediated by FGF-2
JOURNAL OF NEUROBIOLOGY, 55(3), 261–277.
author keywords: agrin; FGF-2; neurite outgrowth; heparan sulfate proteoglycan
MeSH headings : Agrin / pharmacology; Animals; Chick Embryo; Drug Synergism; Fibroblast Growth Factor 2 / pharmacology; Genes, fos / drug effects; Heparan Sulfate Proteoglycans / pharmacology; Humans; Immunoblotting; Mitogen-Activated Protein Kinases / metabolism; Neurites / drug effects; PC12 Cells; Phosphorylation / drug effects; Rats; Retina / drug effects
TL;DR:
The studies suggest that neural agrin contributes to the establishment of axon pathways by modulating the function of neurite promoting molecules such as FGF-2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Association of factor H of the alternative pathway of complement with agrin and complement receptor 3 in the Alzheimer's disease brain
JOURNAL OF NEUROIMMUNOLOGY, 131(1-2), 135–146.
author keywords: Alzheimer's; factor H; heparan sulfate proteoglycan; agrin; complement receptor 3; amyloid beta
MeSH headings : Aged; Agrin / analysis; Agrin / metabolism; Alzheimer Disease / immunology; Alzheimer Disease / metabolism; Alzheimer Disease / pathology; Amyloid beta-Peptides / analysis; Amyloid beta-Peptides / metabolism; Blotting, Western; Brain / immunology; Brain / metabolism; Brain Chemistry; Complement Factor H / analysis; Complement Factor H / immunology; Complement Factor H / metabolism; Complement Pathway, Alternative; Humans; Immunohistochemistry; Macrophage-1 Antigen / analysis; Neuroglia / immunology
TL;DR:
It is proposed that CR3 receptors expressed by microglia are used for ligand binding to factor H bound to HSPGs and Abeta in plaques in the AD brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Expression of basal lamina protein mRNAs in the early embryonic chick eye
JOURNAL OF COMPARATIVE NEUROLOGY, 447(3), 261–273.
author keywords: basal lamina; chick eye; retina; laminin; nidogen; agrin; collagen IV; collagen XVIII; perlecan
MeSH headings : Agrin / genetics; Animals; Basement Membrane / embryology; Basement Membrane / metabolism; Basement Membrane / ultrastructure; Cell Differentiation / genetics; Chick Embryo / metabolism; Chick Embryo / ultrastructure; Ciliary Body / embryology; Ciliary Body / metabolism; Ciliary Body / ultrastructure; Collagen / genetics; Collagen Type IV / genetics; Collagen Type XVIII; Endostatins; Gene Expression Regulation, Developmental / genetics; Heparan Sulfate Proteoglycans / genetics; Laminin / genetics; Membrane Glycoproteins / genetics; Nerve Tissue Proteins / genetics; Peptide Fragments / genetics; RNA, Messenger / metabolism; Retina / embryology; Retina / metabolism; Retina / ultrastructure
TL;DR:
In situ hybridization studies showed that the expression pattern of every basal lamina protein mRNA in the developing eye is unique, and some of the mRNAs have short, transient expressions in the retina, most notably that of collagen IV and laminin gamma 1, which appear in the ventral retina between E4 and E5.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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