Works (1)
Updated: July 5th, 2023 15:59
2002 journal article
Association of factor H of the alternative pathway of complement with agrin and complement receptor 3 in the Alzheimer's disease brain
JOURNAL OF NEUROIMMUNOLOGY, 131(1-2), 135–146.
author keywords: Alzheimer's; factor H; heparan sulfate proteoglycan; agrin; complement receptor 3; amyloid beta
MeSH headings : Aged; Agrin / analysis; Agrin / metabolism; Alzheimer Disease / immunology; Alzheimer Disease / metabolism; Alzheimer Disease / pathology; Amyloid beta-Peptides / analysis; Amyloid beta-Peptides / metabolism; Blotting, Western; Brain / immunology; Brain / metabolism; Brain Chemistry; Complement Factor H / analysis; Complement Factor H / immunology; Complement Factor H / metabolism; Complement Pathway, Alternative; Humans; Immunohistochemistry; Macrophage-1 Antigen / analysis; Neuroglia / immunology
TL;DR:
It is proposed that CR3 receptors expressed by microglia are used for ligand binding to factor H bound to HSPGs and Abeta in plaques in the AD brain.
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Added: August 6, 2018
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