Bruce Wayne Huggins

Works (4)

Updated: July 5th, 2023 15:58

2007 article

Conformational energy and structure in canonical and noncanonical forms of tRNA determined by temperature analysis of the rate of s4U8–C13 photocrosslinking

Huggins, W., Shapkina, T., & Wollenzien, P. (2007, September 13). RNA.

By: W. Huggins n, T. Shapkina n & P. Wollenzien n

author keywords: RNA tertiary structure; photocrosslinking rates; activation energy; conformational energy; T-1 excited state lifetimes
MeSH headings : Base Composition; Base Sequence; Buffers; Cytosine / chemistry; Molecular Sequence Data; Nucleic Acid Conformation; RNA, Bacterial; RNA, Transfer / chemistry; RNA, Transfer, Met / chemistry; RNA, Transfer, Phe / chemistry; RNA, Transfer, Val / chemistry; Temperature; Thermodynamics; Uracil / chemistry
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Peptidase Inhibition and Analysis
TL;DR: Measurements of the temperature dependence of the rate constants for photocrosslinking between the s(4)U8 and C13 have been used to investigate the tRNA conformational energy and structure in Escherichia coli tRNA(Val), tRNA (Phe), and t RNA(fMet) under different conditions. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 article

Internucleotide Movements during Formation of 16 S rRNA–rRNA Photocrosslinks and their Connection to the 30 S Subunit Conformational Dynamics

Huggins, W., Ghosh, S. K., Nanda, K., & Wollenzien, P. (2005, October 20). Journal of Molecular Biology, Vol. 354, pp. 358–374.

By: W. Huggins n, S. Ghosh n , K. Nanda n & P. Wollenzien n

Contributors: W. Huggins n, S. Ghosh n , K. Nanda n & P. Wollenzien n

author keywords: 16 S rRNA tertiary structure; photocrosslinking; conformational flexibility
MeSH headings : Base Pairing; Base Sequence; Binding Sites; Cross-Linking Reagents; Escherichia coli / chemistry; Escherichia coli / genetics; Escherichia coli / radiation effects; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation / radiation effects; Nucleotides / chemistry; Nucleotides / metabolism; Nucleotides / radiation effects; Photochemistry; Protein Conformation / radiation effects; Protein Subunits; RNA, Bacterial / chemistry; RNA, Bacterial / genetics; RNA, Bacterial / radiation effects; RNA, Ribosomal, 16S / chemistry; RNA, Ribosomal, 16S / metabolism; RNA, Ribosomal, 16S / radiation effects; RNA, Transfer / chemistry; RNA, Transfer / genetics; RNA, Transfer / metabolism; Ribosomal Proteins / chemistry; Ribosomal Proteins / genetics; Ribosomal Proteins / metabolism; Ribosomes / chemistry; Ribosomes / metabolism; Ribosomes / radiation effects; Ultraviolet Rays
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; DNA and Nucleic Acid Chemistry
TL;DR: Results show that photocrosslinking is an indicator for sites where there is internucleotide conformational flexibility and these sites are largely restricted to parts of the 30 S subunit associated with ribosome function. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 article

A 16S rRNA-tRNA product containing a nucleotide phototrimer and specific for tRNA in the P/E hybrid state in the Escherichia coli ribosome

Huggins, W. (2004, December 14). Nucleic Acids Research.

By: W. Huggins n

MeSH headings : Base Sequence; Binding Sites; Escherichia coli / genetics; Kinetics; Light; Molecular Sequence Data; Nucleotides / analysis; Puromycin / pharmacology; RNA, Bacterial / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Ribosomal, 16S / metabolism; RNA, Transfer, Amino Acyl / chemistry; RNA, Transfer, Amino Acyl / metabolism; RNA, Transfer, Val / chemistry; RNA, Transfer, Val / metabolism; Ribosomes / chemistry; Ribosomes / metabolism; Ribosomes / radiation effects; Transcription, Genetic
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; DNA and Nucleic Acid Chemistry
TL;DR: Results indicate an altered interaction between the tRNA anticodon and the 30S subunit for the t RNA in the P/E hybrid state compared with its interaction in the classic P/P state. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 article

Conformational Change in the 16S rRNA in the Escherichia coli 70S Ribosome Induced by P/P- and P/E-Site tRNAPhe Binding

Noah, J. W., Shapkina, T. G., Nanda, K., Huggins, W., & Wollenzien, P. (2003, November 14). Biochemistry.

By: J. Noah n, T. Shapkina n, K. Nanda n, W. Huggins n & P. Wollenzien n

MeSH headings : Acetylation / radiation effects; Binding Sites / radiation effects; Cytosine / chemistry; Cytosine / radiation effects; Escherichia coli / chemistry; Escherichia coli / genetics; Escherichia coli / radiation effects; Nucleic Acid Conformation / radiation effects; Peptide Chain Elongation, Translational / genetics; Peptide Chain Elongation, Translational / radiation effects; Photochemistry; Poly U / chemistry; Poly U / genetics; RNA, Bacterial / chemistry; RNA, Bacterial / genetics; RNA, Bacterial / radiation effects; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA, Messenger / radiation effects; RNA, Ribosomal, 16S / chemistry; RNA, Ribosomal, 16S / genetics; RNA, Ribosomal, 16S / radiation effects; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / radiation effects; Ribosomes / chemistry; Ribosomes / genetics; Ribosomes / radiation effects; Transcription, Genetic / radiation effects; Ultraviolet Rays
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Bacteriophages and microbial interactions
TL;DR: Results indicate a limited structural change in the small subunit around C967 and C1400 during tRNA P-site binding sensitive to the type of mRNA that is used, and indicates an alternative arrangement in this region in empty ribosomes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.