Works (1)
Updated: July 5th, 2023 15:57
2005 journal article
Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice
BRAIN RESEARCH, 1033(1), 96–101.
author keywords: progesterone; neurosteroid; allopregnanolone; progesterone receptor; sleep; righting reflex
MeSH headings : Analysis of Variance; Anesthetics / blood; Anesthetics / pharmacology; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors / pharmacology; Female; Finasteride / pharmacology; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnanolone / blood; Pregnanolone / pharmacology; Progesterone / pharmacology; Reaction Time / drug effects; Receptors, Progesterone / deficiency; Receptors, Progesterone / genetics; Reflex / drug effects
TL;DR:
The neurosteroid allopregnanolone partially mediates the anesthetic activity of progesterone by potentiation of GABA(A) receptor function, but this activity is not mediated by its interaction with PRs.
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Added: August 6, 2018
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