Megan A. Leon

Works (2)

Updated: August 3rd, 2023 21:15

2008 journal article

West Nile virus nonstructural protein 1 inhibits TLR3 signal transduction

JOURNAL OF VIROLOGY, 82(17), 8262–8271.

By: J. Wilson  n, P. Sessions  n, M. Leon n & F. Scholle n

MeSH headings : Animals; Chlorocebus aethiops; Genes, Reporter; HeLa Cells; Humans; Immunity, Innate; Immunohistochemistry; Luciferases / metabolism; Plasmids; Replicon; Signal Transduction / immunology; Signal Transduction / physiology; Toll-Like Receptor 3 / antagonists & inhibitors; Vero Cells; Viral Nonstructural Proteins / physiology; Viral Plaque Assay; West Nile virus / immunology; West Nile virus / physiology
TL;DR: A previously unrecognized role for NS1 is identified in the modulation of signaling pathways of the innate immune response to WNV infection, which inhibited TLR3-dependent production of interleukin-6 and the establishment of an antiviral state. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Early production of type I interferon during West Nile virus infection: Role for lymphoid tissues in IRF3-independent interferon production

Journal of Virology, 81(17), 9100–9108.

By: N. Bourne n, F. Scholle*, M. Silva*, S. Rossi *, N. Dewsbury*, B. Judy *, J. De Aguiar*, M. Leon* ...

MeSH headings : Animals; Antigens, Viral / analysis; Disease Models, Animal; Gene Expression; Interferon Regulatory Factor-3 / genetics; Interferon Regulatory Factor-3 / immunology; Interferon Type I / biosynthesis; Interferon Type I / blood; Interferon Type I / immunology; Lymph Nodes / virology; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger / biosynthesis; West Nile Fever / immunology; West Nile virus / immunology
TL;DR: To investigate IFN gene induction by the very first cells infected during in vivo infection with the flavivirus West Nile virus, mice were infected with high-titer preparations of WNV virus-like particles, which initiate viral genome replication in cells but fail to spread. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

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