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Works (35)
Updated: August 22nd, 2024 05:00
2024 article
Chlorophyllin as a photosensitizer in photodynamic antimicrobial materials
Jiang, C., Scholle, F., Jin, F., Wei, Q., Wang, Q., & Ghiladi, R. A. (2024, February 8). CELLULOSE, Vol. 2.
author keywords: Antimicrobial; Chlorophyllin; Photodynamic inactivation; Photothermal inactivation
open access via doi.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 19, 2024
2024 journal article
Facile Synthesis of Cu-Doped TiO<sub>2</sub> Particles for Accelerated Visible Light-Driven Antiviral and Antibacterial Inactivation
ACS APPLIED ENGINEERING MATERIALS, 2(5), 1411–1423.
author keywords: doping; TiO2; antimicrobial photodynamicinactivation; photosensitizer; antimicrobial coating
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 8, 2024
2023 journal article
A rapid, high-throughput, viral infectivity assay using automated brightfield microscopy with machine learning
SLAS Technology, 28(5), 324–333.
author keywords: Viral infectivity assay; Antiviral screening; Brightfield microscopy; Label-free assays; Cell-based assays; Machine learning; Convolutional neural networks
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: July 13, 2023
2022 journal article
<p>Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E</p>
VIROLOGY, 571, 21–33.
author keywords: (+)-dihydrokaempferol; <p>(+)-dihydroquercetin (taxifolin)</p>; (+)-dihydromyricetin; Kaempferol; Quercetin; Myricentin; Isoquercitrin; Rutin; Flavan-3-ols
MeSH headings : COVID-19; Coronavirus 229E, Human / drug effects; Coronavirus 229E, Human / physiology; Coronavirus 3C Proteases / antagonists & inhibitors; Flavonols / pharmacology; Humans; Molecular Docking Simulation; SARS-CoV-2 / drug effects; Virus Replication / drug effects
TL;DR:
In vitro inhibition assays showed that seven available compounds effectively inhibited the SARS-CoV-2 Mpro activity and their IC50 values ranged from 0.125 to 12.9 µM, which indicates that these antioxidative flavonols and dihydroflavonols are promising candidates for curbing the two viruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022
2022 article
A standardized procedure for quantitative evaluation of residual viral activity on antiviral treated textiles
Wang, Z., Amanah, A. Y., Ali, K. M., Payne, L. C., Kisthardt, S., Scholle, F., … Gluck, J. M. (2022, November 2). TEXTILE RESEARCH JOURNAL, Vol. 11.
author keywords: SARS-CoV-2; antiviral textiles; Tissue Culture Infectious Dose 50
TL;DR:
This pilot study aims to develop and refine a standardized protocol to quantitatively evaluate residual viral activity on antiviral textiles and used HCoV-229E and Huh-7 human liver cancer cells for this investigation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 3, 2022
2022 journal article
Chalcones from Angelica keiskei (ashitaba) inhibit key Zika virus replication proteins
BIOORGANIC CHEMISTRY, 120.
author keywords: Angelica keiskei; Ashitaba; Chalcones; Zika virus; Polymerase; Protease
MeSH headings : Angelica / chemistry; Animals; Chalcone / pharmacology; Chalcones / chemistry; Chalcones / pharmacology; Chlorocebus aethiops; Humans; RNA; RNA-Dependent RNA Polymerase; Vero Cells; Virus Replication; Zika Virus; Zika Virus Infection
TL;DR:
With their simple structures and relative ease of modification, the chalcones represent attractive candidates for hit-to-lead optimization in the search of new anti-ZIKV therapeutics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 18, 2022
2022 journal article
Effect of BIO-PLYTM, a Platelet-Rich Plasma Derived Biologic on PRRSV-2-Infected Macrophages
Viruses, 14(12), 2666.
author keywords: antivirals; biologic; porcine macrophages; PRRSV
MeSH headings : Humans; Swine; Animals; Horses; Porcine respiratory and reproductive syndrome virus; Porcine Reproductive and Respiratory Syndrome / prevention & control; Macrophages; Biological Products
TL;DR:
The results show that BIO-PLYTM significantly reduces the amount of PRRSV viral load determined by RT-qPCR and the number of infectious viral particles measured by TCID50 in infected porcine alveolar and parenchymal macrophages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: November 29, 2022
2022 journal article
On-demand, remote and lossless manipulation of biofluid droplets
Materials Horizons, 9(11), 2863–2871.
MeSH headings : Humans; Pandemics / prevention & control; Saliva; Disease Outbreaks; Point-of-Care Systems; Health Personnel
TL;DR:
This work presents biofluid manipulators, which allow on-demand, remote and lossless manipulation of virtually any liquid droplet, and envision that these manipulators will not only reduce manual operations and minimize exposure to infectious agents, but also pave the way for developing inexpensive, simple and portable robotic systems, which can allow point-of-care operations, particularly in developing nations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 19, 2022
2022 journal article
Vandetanib Blocks the Cytokine Storm in SARS-CoV-2-Infected Mice
ACS OMEGA, 7(36), 31935–31944.
TL;DR:
The results indicate that the FDA-approved anticancer drug vandetanib is worthy of further assessment as a potential therapeutic candidate to block the COVID-19 cytokine storm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 3, 2023
2021 journal article
A Liquid Metal Mediated Metallic Coating for Antimicrobial and Antiviral Fabrics
Advanced Materials, 33(45), 2104298.
author keywords: antimicrobial; antiviral; galvanic replacement; liquid metal fabric coating
MeSH headings : Alloys / chemistry; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Antiviral Agents / chemistry; Antiviral Agents / pharmacology; Bacteria / drug effects; Coated Materials, Biocompatible / chemistry; Coated Materials, Biocompatible / pharmacology; Copper / chemistry; Fungi / drug effects; Gallium / chemistry; Textiles / analysis; Viruses / drug effects
TL;DR:
The presence of the LMCu particles can eradicate over 99% of pathogens within 5 min, which is significantly more effective than control samples coated with only Cu, and is promising for generating robust antibacterial, antifungal, and antiviral fabrics and surfaces.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 28, 2021
2021 journal article
Rapid and Repetitive Inactivation of SARS-CoV-2 and Human Coronavirus on Self-Disinfecting Anionic Polymers
ADVANCED SCIENCE, 8(11).
author keywords: antiviral materials; charged block polymers; microphase‐ ordered materials; polyanions; thermoplastic elastomers
MeSH headings : COVID-19 / prevention & control; COVID-19 / transmission; COVID-19 / virology; Disinfectants / therapeutic use; Humans; Pandemics; Polymers / chemistry; Polymers / therapeutic use; SARS-CoV-2 / drug effects; SARS-CoV-2 / pathogenicity
TL;DR:
It is demonstrated that an architecturally‐ and chemically‐diverse family of nanostructured anionic polymers yield a rapid and continuous disinfecting alternative to inactivate coronaviruses and prevent their transmission from contact with contaminated surfaces.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021
2021 journal article
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms
ACS OMEGA, 6(11), 7454–7468.
TL;DR:
Tilorone and pyronaridine inhibited the virus replication in A549-ACE2 cells with IC50 values of 180 nM and IC50 198 nM, respectively and novel insights are provided into the mechanism of these compounds which is likely lysosomotropic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021
2021 journal article
Toward Universal Photodynamic Coatings for Infection Control
FRONTIERS IN MEDICINE, 8.
author keywords: antimicrobial; Coronavirus; coatings; photodynamic inactivation; photosensitizer; polymer; singlet oxygen; Staphylococcus aureus
TL;DR:
The antimicrobial efficacy of a simple bicomponent spray coating composed of the commercially-available UV-photocrosslinkable polymer N-methyl-4(4'-formyl-styryl)pyridinium methosulfate acetal poly(vinyl alcohol) (SbQ-PVA) and one of three aPDI photosensitizers (PSs) is evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 23, 2021
2020 journal article
Photodynamic Coatings on Polymer Microfibers for Pathogen Inactivation: Effects of Application Method and Composition
ACS Applied Materials & Interfaces, 13(1), 155–163.
author keywords: hospital-acquired infections; photodynamic coatings; porphyrin photosensitizer; SARS-CoV-2 virus; polymer microfibers
MeSH headings : COVID-19 / prevention & control; COVID-19 / virology; Escherichia coli / drug effects; Escherichia coli / pathogenicity; Humans; Iatrogenic Disease / prevention & control; Light; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / pathogenicity; Microfibrils / chemistry; Pandemics; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Polymers / chemistry; Polymers / pharmacology; Porphyrins / chemistry; Porphyrins / pharmacology; SARS-CoV-2 / drug effects; SARS-CoV-2 / pathogenicity; Singlet Oxygen
TL;DR:
These coated fibers can inactivate a human common cold coronavirus serving as a surrogate for the SARS-CoV-2 virus and are confirmed to be able to inactivate antibiotic-resistant bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: January 31, 2021
2019 journal article
A facile strategy for photoactive nanocellulose-based antimicrobial materials
Green Chemistry, 21(12), 3424–3435.
TL;DR:
Anti-infective materials based upon renewable nanocellulose–porphyrin conjugates photodynamically inactivated four strains of drug-resistant bacteria and two viruses by 99.999+%.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: July 8, 2019
2019 journal article
BODIPY-embedded electrospun materials in antimicrobial photodynamic inactivation
Photochemical & Photobiological Sciences, 18(8), 1923–1932.
Contributors: R. Ghiladi n , X. Zhang n , J. Zhu n, n & K. Stoll*
MeSH headings : Acinetobacter baumannii / drug effects; Acrylic Resins / chemistry; Acrylic Resins / pharmacology; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Boron Compounds / chemistry; Boron Compounds / pharmacology; Klebsiella pneumoniae / drug effects; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Nanofibers / chemistry; Nylons / chemistry; Nylons / pharmacology; Particle Size; Photochemotherapy; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Vancomycin-Resistant Enterococci / drug effects
TL;DR:
The results demonstrate the potential for electrospun BODIPY ^(+)-embedded nanofiber materials as the basis for pathogen-specific anti-infective materials, even at low photosensitizer loadings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: September 16, 2019
2019 journal article
Inherently self-sterilizing charged multiblock polymers that kill drug-resistant microbes in minutes
Materials Horizons, 6(10), 2056–2062.
TL;DR:
It is demonstrated that midblock-sulfonated block polymers can kill 99.9999% of “superbugs,” including bacteria and viruses, in just 5 minutes due to an abrupt pH reduction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 16, 2019
2018 journal article
Photodynamic Polymers as Comprehensive Anti-Infective Materials: Staying Ahead of a Growing Global Threat
ACS Applied Materials & Interfaces, 10(31), 25955–25959.
author keywords: antimicrobial photodynamic inactivation; antibacterial surface; anti-infective polymer; antibiotic-resistant bacteria; antiviral; block copolymer; olefin thermoplastic elastomer
MeSH headings : Anti-Infective Agents / chemistry; Light; Photosensitizing Agents; Polymers; Singlet Oxygen
TL;DR:
The anti-infective efficacy of bulk thermoplastic elastomer films containing zinc-tetra(4- N-methylpyridyl)porphine (ZnTMPyP4+), a photoactive antimicrobial that utilizes visible light to generate singlet oxygen, is explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 5, 2020
2016 journal article
Dengue virus NS1 enhances viral replication and pro-inflammatory cytokine production in human dendritic cells
VIROLOGY, 496, 227–236.
author keywords: Dengue; NS1; Nonstructural protein NS1; Dendritic cells; Proinflammatory cytokines; Immune modulation
MeSH headings : Cells, Cultured; Cytokines / biosynthesis; Dendritic Cells / immunology; Dendritic Cells / metabolism; Dendritic Cells / virology; Dengue / immunology; Dengue / metabolism; Dengue / virology; Dengue Virus / classification; Dengue Virus / physiology; Humans; Immunomodulation; Inflammation Mediators / metabolism; Serogroup; Viral Nonstructural Proteins / metabolism; Virus Replication
TL;DR:
The presence of exogenous NS1 is able to modulate dengue infection in mo-DCs and produced more pro-inflammatory cytokines in response to subsequent DV infection compared to DCs exposed to heat-inactivated NS1 (HNS1).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
13. Climate Action
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Photosensitizer-Embedded Polyacrylonitrile Nanofibers as Antimicrobial Non-Woven Textile
Nanomaterials, 6(4), 77.
Contributors: R. Ghiladi n , X. Situ n, X. Zhang n , Y. Lu n, J. Zhu n, n, S. Stanley n
author keywords: photodynamic inactivation; singlet oxygen; antibacterial; antiviral; photobiocidal; polyacrylonitrile; photosensitizer; porphyrin
TL;DR:
The results demonstrate the potential of photosensitizer-embedded polyacrylonitrile nanofibers to serve as scalable scaffolds for anti-infective or self-sterilizing materials against both bacteria and viruses when employing a photodynamic inactivation mode of action.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
The adaptor molecule Trif contributes to murine host defense during Leptospiral infection
IMMUNOBIOLOGY, 221(9), 964–974.
author keywords: Leptospira interrogans; Leptospirosis; Innate immunity; TRIF
MeSH headings : Adaptor Proteins, Vesicular Transport / genetics; Adaptor Proteins, Vesicular Transport / immunology; Animals; Cytokines / blood; Cytokines / genetics; Cytokines / immunology; Immunoglobulin A / immunology; Immunoglobulin M / immunology; Kidney / immunology; Leptospira / immunology; Leptospirosis / immunology; Lung / immunology; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger / metabolism
TL;DR:
Multiple components of the innate immune responses were dampened in response to leptospiral infection including transcription and production of cytokines, and the humoral response, which suggested that TRIF contributes to expression and productionof cytokines important for the host defense against L. interrogans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Antiviral, antifungal and antibacterial activities of a BODIPY-based photosensitizer
Molecules, 20(6), 10604–10621.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1 beta Secretion: A Primary Human Monocyte Model
PLOS ONE, 10(8).
MeSH headings : Animals; Antibodies, Neutralizing / administration & dosage; Antibodies, Viral / administration & dosage; Antibodies, Viral / immunology; Chlorocebus aethiops; Dengue Virus / immunology; Dengue Virus / pathogenicity; Humans; Interleukin-1beta / immunology; Interleukin-1beta / metabolism; Monocytes / immunology; Monocytes / virology; Severe Dengue / immunology; Severe Dengue / virology; Vero Cells; Virus Replication / immunology
TL;DR:
This study indicates that Vero cells infected with DENV-2 16681 may produce inflammatory components during dengue virus propagation that mask the virus-specific immune response, and insect-derived virus represents a system that elicits antibody-dependent cytokine responses to d Dengue virus with fewer confounding issues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Synthesis, Characterization, and Antimicrobial Efficacy of Photomicrobicidal Cellulose Paper
BIOMACROMOLECULES, 16(8), 2482–2492.
Contributors: B. Carpenter*, *, H. Sadeghifar*, A. Francis*, J. Boltersdorf*, W. Weare*, D. Argyropoulos* , P. Maggard* , R. Ghiladi*
MeSH headings : Anti-Infective Agents / administration & dosage; Anti-Infective Agents / chemical synthesis; Anti-Infective Agents / chemistry; Cellulose / administration & dosage; Cellulose / chemical synthesis; Cellulose / chemistry; Enterococcus faecium / drug effects; Humans; Klebsiella pneumoniae / drug effects; Light; Microbial Sensitivity Tests; Paper; Photosensitizing Agents / chemical synthesis; Photosensitizing Agents / chemistry; Porphyrins / administration & dosage; Porphyrins / chemical synthesis; Porphyrins / chemistry; Pseudomonas aeruginosa / drug effects; Staphylococcus aureus / drug effects
TL;DR:
The results demonstrate the potential of cellulose materials to serve as scalable scaffolds for anti-infective or self-sterilizing materials against both bacteria and viruses when employing a photodynamic inactivation mode of action.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Abrogation of TLR3 inhibition by discrete amino acid changes in the C-terminal half of the West Nile virus NS1 protein
VIROLOGY, 456, 96–107.
author keywords: Flavivirus; West Nile virus; TLR3; NS1; Innate immunity
MeSH headings : Amino Acid Substitution; DNA Mutational Analysis; HeLa Cells; Host-Pathogen Interactions; Humans; Immune Evasion; Mutant Proteins / genetics; Mutant Proteins / immunology; Toll-Like Receptor 3 / antagonists & inhibitors; Toll-Like Receptor 3 / immunology; Viral Nonstructural Proteins / genetics; Viral Nonstructural Proteins / immunology; Virus Replication; West Nile virus / genetics; West Nile virus / immunology; West Nile virus / physiology
TL;DR:
A novel FACS-based screen to attempt to separate the functions of the WNV non-structural protein 1 and virus replication was developed, suggesting that the two functions are not easily separated and may be contained within overlapping domains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Modulation of innate immune signaling by the secreted form of the West Nile virus NS1 glycoprotein
VIROLOGY, 458, 172–182.
author keywords: West Nile virus; Flaviviridae; Nonstructural protein; Toll like receptor; Innate immunity
MeSH headings : Animals; HeLa Cells; Humans; Immunity, Innate; Luciferases / metabolism; Macrophages / immunology; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Myeloid Cells / immunology; Myeloid Cells / metabolism; Poly I-C / pharmacology; Signal Transduction / immunology; Specific Pathogen-Free Organisms; Toll-Like Receptor 3 / antagonists & inhibitors; Viral Nonstructural Proteins / immunology; Viral Nonstructural Proteins / physiology; West Nile virus / immunology; West Nile virus / metabolism
TL;DR:
Investigating whether the secreted form of NS1 inhibits innate immune signaling pathways in uninfected cells reduces TLR3 signaling and WNV replicon particle-mediated cytokine transcription in popliteal lymph nodes found the protein associated predominantly with macrophages and dendritic cells in the draining lymph node.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Replication of Many Human Viruses Is Refractory to Inhibition by Endogenous Cellular MicroRNAs
JOURNAL OF VIROLOGY, 88(14), 8065–8076.
MeSH headings : Animals; Cell Line; Gene Silencing; Host-Pathogen Interactions; Humans; Immune Evasion; MicroRNAs / genetics; MicroRNAs / immunology; Virus Replication; Viruses / genetics; Viruses / growth & development; Viruses / immunology
TL;DR:
It is demonstrated that the replication of a wide range of pathogenic viruses is not enhanced in human cells engineered to be unable to produce mi RNAs, indicating that viruses have evolved to be resistant to inhibition by miRNAs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Intrinsic adjuvanting of a novel single-cycle flavivirus vaccine in the absence of type I interferon receptor signaling
VACCINE, 30(8), 1465–1475.
author keywords: West Nile virus; Single-cycle virus; CD8(+) T cell; Type I IFN
MeSH headings : Adjuvants, Immunologic / pharmacology; Animals; Antibodies, Viral / blood; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Immunoglobulin G / blood; Lymph Nodes / immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Interferon alpha-beta / deficiency; Receptor, Interferon alpha-beta / immunology; Signal Transduction; West Nile Fever / immunology; West Nile Fever / prevention & control; West Nile Virus Vaccines / immunology
TL;DR:
Results indicate that although type I IFN is not essential for the intrinsic adjuvanting of RepliVAX WN, it plays a role in shaping the cytokine secretion profiles of CD8(+) effector T cells elicited by this SCFV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus
BMC GENOMICS, 11.
MeSH headings : Aedes / genetics; Aedes / virology; Animals; Cell Line; Computational Biology; Culex / genetics; Culex / virology; Female; Insect Vectors / genetics; MicroRNAs / genetics; Sequence Analysis, RNA; West Nile virus
TL;DR:
Evidence is provided for over 60 conserved and seven novel mosquito miRNAs, expanding upon the current understanding of insect miRNAAs, which are important flavivirus vectors for Aedes and Culex mosquitoes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-kappa B-dependent transcription of TNF-alpha and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA
JOURNAL OF INFLAMMATION-LONDON, 7.
TL;DR:
TMP acts indirectly as an inhibitor of NF-κB-dependent transcription by preventing RelA from binding the promoters of certain key cytokine and chemokine genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines
JOURNAL OF INFLAMMATION-LONDON, 6.
TL;DR:
TMP inhibited the LPS-induced production of lipid mediators and several key inflammatory cytokines and chemokines, both in vitro and in vivo, raising the possibility that TMP might be useful as a treatment for a variety of inflammatory disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
West Nile virus nonstructural protein 1 inhibits TLR3 signal transduction
JOURNAL OF VIROLOGY, 82(17), 8262–8271.
MeSH headings : Animals; Chlorocebus aethiops; Genes, Reporter; HeLa Cells; Humans; Immunity, Innate; Immunohistochemistry; Luciferases / metabolism; Plasmids; Replicon; Signal Transduction / immunology; Signal Transduction / physiology; Toll-Like Receptor 3 / antagonists & inhibitors; Vero Cells; Viral Nonstructural Proteins / physiology; Viral Plaque Assay; West Nile virus / immunology; West Nile virus / physiology
TL;DR:
A previously unrecognized role for NS1 is identified in the modulation of signaling pathways of the innate immune response to WNV infection, which inhibited TLR3-dependent production of interleukin-6 and the establishment of an antiviral state.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Early production of type I interferon during West Nile virus infection: Role for lymphoid tissues in IRF3-independent interferon production
Journal of Virology, 81(17), 9100–9108.
MeSH headings : Animals; Antigens, Viral / analysis; Disease Models, Animal; Gene Expression; Interferon Regulatory Factor-3 / genetics; Interferon Regulatory Factor-3 / immunology; Interferon Type I / biosynthesis; Interferon Type I / blood; Interferon Type I / immunology; Lymph Nodes / virology; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger / biosynthesis; West Nile Fever / immunology; West Nile virus / immunology
TL;DR:
To investigate IFN gene induction by the very first cells infected during in vivo infection with the flavivirus West Nile virus, mice were infected with high-titer preparations of WNV virus-like particles, which initiate viral genome replication in cells but fail to spread.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Evaluation of replicative capacity and genetic stability of West Nile virus replicons using highly efficient packaging cell lines
Virology, 351(1), 196–209.
author keywords: flavivirus; replicon; packaging; virus-like particle; noncytopathic replicon
MeSH headings : Animals; Chlorocebus aethiops; Cricetinae; Genetic Variation; Vero Cells; Virus Assembly; Virus Replication / physiology; West Nile virus / genetics; West Nile virus / physiology
TL;DR:
Interestingly, a rapid loss of replicon-encoded reporter gene activity was detected within two serial passages of reporter gene-containing VLPs, indicating a powerful selection pressure for WNV genomes lacking reporter genes.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2005 journal article
West Nile virus replication interferes with both poly(I:C)-induced interferon gene transcription and response to interferon treatment
Virology, 342(1), 77–87.
author keywords: West Nile virus; interferon; TLR3; IRF3; innate immunity; double-stranded RNA
MeSH headings : Active Transport, Cell Nucleus; Cell Line; Dimerization; HeLa Cells; Humans; Immunity, Innate; Interferon Regulatory Factor-3 / chemistry; Interferon Regulatory Factor-3 / metabolism; Interferon-beta / biosynthesis; Interferon-beta / genetics; Poly I-C / pharmacology; RNA, Viral / genetics; Replicon; STAT1 Transcription Factor / metabolism; Signal Transduction; Transcription, Genetic / drug effects; Virus Replication; West Nile virus / genetics; West Nile virus / immunology; West Nile virus / pathogenicity; West Nile virus / physiology
TL;DR:
It is demonstrated that WNV replication in cultured cells interferes with both the response to IFN and synthesis of IFN-beta in response to dsRNA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
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