Bradley Thomas Ferguson

Works (3)

Updated: August 7th, 2023 21:15

2014 article

Benefits of Model-based Drug Development: A Rigorous, Planned Case Study

COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION, Vol. 44, pp. 2210–2222.

By: R. Reeve*, S. Berry*, W. Xiao n, B. Ferguson n, M. Thuerk & R. Goetz

author keywords: Adaptive trial; Bayesian; Dose response; Model-based drug development; Phase I; Phase II
TL;DR: The conclusion is that the use of MBDD could have facilitated more efficient use of resources in the traditional drug development process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Set-Valued Dynamic Treatment Regimes for Competing Outcomes

BIOMETRICS, 70(1), 53–61.

By: E. Laber n, D. Lizotte * & B. Ferguson n

author keywords: Competing outcomes; Composite outcomes; Dynamic treatment regimes; Personalized medicine; Preference elicitation
MeSH headings : Algorithms; Antipsychotic Agents / administration & dosage; Antipsychotic Agents / adverse effects; Antipsychotic Agents / therapeutic use; Body Mass Index; Clinical Protocols; Clinical Trials as Topic / methods; Decision Making; Humans; Models, Statistical; Schizophrenia / drug therapy; Treatment Outcome
TL;DR: This work proposes a method for constructing DTRs that accommodates competing outcomes by recommending sets of treatments at each decision point, and offers an exact enumeration algorithm by recasting the problem as a linear mixed integer program. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Rheumatoid Arthritis Disease Progression Modeling

THERAPEUTIC INNOVATION & REGULATORY SCIENCE, 47(6), 641–650.

By: R. Reeve*, L. Pang*, B. Ferguson n, M. O'Kelly *, S. Berry* & W. Xiao n

author keywords: rheumatoid arthritis; time progression model; nonlinear model; ACR20; DMARD; TNF inhibitor
TL;DR: A meta-analysis of time progression models for rheumatoid arthritis shows that an exponential time response model adequately fits the data and a distribution of effects for biological RA therapies can be provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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