Wei Xiao

Works (3)

Updated: July 5th, 2023 15:43

2015 article

Benefits of Model-based Drug Development: A Rigorous, Planned Case Study

COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION, Vol. 44, pp. 2210–2222.

By: R. Reeve*, S. Berry*, W. Xiao n, B. Ferguson n, M. Thuerk & R. Goetz

author keywords: Adaptive trial; Bayesian; Dose response; Model-based drug development; Phase I; Phase II
topics (OpenAlex): Computational Drug Discovery Methods; Statistical Methods in Clinical Trials; Viral Infectious Diseases and Gene Expression in Insects
TL;DR: The conclusion is that the use of MBDD could have facilitated more efficient use of resources in the traditional drug development process. (via Semantic Scholar)
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Added: August 6, 2018

2015 journal article

ConvexLAR: An Extension of Least Angle Regression

JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS, 24(3), 603–626.

By: W. Xiao n, Y. Wu n & H. Zhou n

author keywords: Solution path; Group lasso; Regularization; Ordinary differential equation (ODE); Lasso
topics (OpenAlex): Statistical Methods and Inference; Advanced Statistical Methods and Models; Statistical Methods and Bayesian Inference
TL;DR: This article proposes a ConvexLAR algorithm that works for any convex loss function and naturally extends to group selection and data adaptive variable selection and yields new exact path algorithms for certain penalty methods such as a conveX loss function with lasso or group lasso penalty. (via Semantic Scholar)
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Added: August 6, 2018

2013 journal article

Rheumatoid Arthritis Disease Progression Modeling

THERAPEUTIC INNOVATION & REGULATORY SCIENCE, 47(6), 641–650.

By: R. Reeve*, L. Pang*, B. Ferguson n, M. O'Kelly *, S. Berry* & W. Xiao n

author keywords: rheumatoid arthritis; time progression model; nonlinear model; ACR20; DMARD; TNF inhibitor
topics (OpenAlex): Rheumatoid Arthritis Research and Therapies; Monoclonal and Polyclonal Antibodies Research; Biosimilars and Bioanalytical Methods
TL;DR: A meta-analysis of time progression models for rheumatoid arthritis shows that an exponential time response model adequately fits the data and a distribution of effects for biological RA therapies can be provided. (via Semantic Scholar)
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Added: August 6, 2018

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