Works (2)

Updated: July 5th, 2023 15:38

2021 journal article

Sirtuin 5 Is Regulated by the SCFCyclin (F) Ubiquitin Ligase and Is Involved in Cell Cycle Control


author keywords: cyclin F (CCNF); sirtuin 5 (SIRT5); cell cycle; ubiquitin; metabolism; SCF
MeSH headings : Cell Cycle / genetics; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; F-Box Proteins / genetics; F-Box Proteins / metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Lethal; HEK293 Cells; HeLa Cells; Humans; Mutation; Protein Processing, Post-Translational; SKP Cullin F-Box Protein Ligases / genetics; SKP Cullin F-Box Protein Ligases / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Signal Transduction; Sirtuins / genetics; Sirtuins / metabolism; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
TL;DR: It is shown that cyclin F interacts with and controls the ubiquitination, abundance, and stability of SIRT5, which is a mitochondrial and cytosolic deacylating enzyme that has been implicated in metabolic processes, but its connection to the cell cycle is not known. (via Semantic Scholar)
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Source: Web Of Science
Added: March 15, 2021

2016 journal article

APC/C and SCFcyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry

CELL REPORTS, 16(12), 3359–3372.

By: R. Choudhury*, T. Bonacci*, A. Arceci*, D. Lahiri n, C. Mills*, J. Kernan*, T. Branigan*, J. DeCaprio*, D. Burke n, M. Emanuele*

MeSH headings : Anaphase-Promoting Complex-Cyclosome / metabolism; Cyclins / metabolism; Feedback, Physiological / physiology; HEK293 Cells; HeLa Cells; Humans; S Phase / physiology
TL;DR: A reciprocal feedback circuit between APC/C and a second ubiquitin ligase, the SCF, is described and it is shown that cyclin F, a cell-cycle-regulated substrate receptor for the SCF, is targeted for degradation by APC/C. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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