Debojyoti Lahiri

Works (2)

Updated: July 5th, 2023 15:38

2021 journal article

Sirtuin 5 Is Regulated by the SCFCyclin (F) Ubiquitin Ligase and Is Involved in Cell Cycle Control

MOLECULAR AND CELLULAR BIOLOGY, 41(2).

By: C. Mills *, X. Wang*, D. Bhatt *, P. Grimsrud *, J. Matson *, D. Lahiri n, D. Burke n, J. Cook*, M. Hirschey *, M. Emanuele *

author keywords: cyclin F (CCNF); sirtuin 5 (SIRT5); cell cycle; ubiquitin; metabolism; SCF
MeSH headings : Cell Cycle / genetics; Cell Cycle Proteins / genetics; Cell Cycle Proteins / metabolism; F-Box Proteins / genetics; F-Box Proteins / metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Lethal; HEK293 Cells; HeLa Cells; Humans; Mutation; Protein Processing, Post-Translational; SKP Cullin F-Box Protein Ligases / genetics; SKP Cullin F-Box Protein Ligases / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism; Signal Transduction; Sirtuins / genetics; Sirtuins / metabolism; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
TL;DR: It is shown that cyclin F interacts with and controls the ubiquitination, abundance, and stability of SIRT5, which is a mitochondrial and cytosolic deacylating enzyme that has been implicated in metabolic processes, but its connection to the cell cycle is not known. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 15, 2021

2016 journal article

APC/C and SCFcyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry

CELL REPORTS, 16(12), 3359–3372.

By: R. Choudhury*, T. Bonacci*, A. Arceci*, D. Lahiri n, C. Mills *, J. Kernan*, T. Branigan*, J. DeCaprio *, D. Burke n, M. Emanuele *

MeSH headings : Anaphase-Promoting Complex-Cyclosome / metabolism; Cyclins / metabolism; Feedback, Physiological / physiology; HEK293 Cells; HeLa Cells; Humans; S Phase / physiology
TL;DR: A reciprocal feedback circuit between APC/C and a second ubiquitin ligase, the SCF, is described and it is shown that cyclin F, a cell-cycle-regulated substrate receptor for the SCF, is targeted for degradation by APC/C. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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