A topological data analysis study on murine pulmonary arterial trees with pulmonary hypertension
Miller, M., Johnston, N., Livengood, I., Spinelli, M., Sazdanovic, R., & Olufsen, M. S. (2023, August 6). Mathematical Biosciences, Vol. 364.
author keywords: Pulmonary hypertension; Vascular remodeling; Image segmentation; Tree pruning; Strahler order; Persistent homology; Topological data analysis; TDA
MeSH headings : Mice; Animals; Pulmonary Artery / diagnostic imaging; Hypertension, Pulmonary / diagnostic imaging; Hypertension, Pulmonary / complications; X-Ray Microtomography; Hypoxia / complications; Vascular Remodeling
topics (OpenAlex): Clusterin in disease pathology; Bioinformatics and Genomic Networks; Medical Imaging Techniques and Applications
TL;DR:
This study analyzes the change in pulmonary arterial morphometry in the presence of HPH using novel methods from topological data analysis (TDA) and finds that HPH trees are stiffer than control trees but have more branches and a higher depth.
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