Peter J. Bentley

Works (11)

Updated: July 31st, 2023 18:05

1991 article

Effects of a zinc-deficient diet on tissue zinc concentrations in rabbits

Bentley, P. J., & Grubb, B. R. (1991, December 1). Journal of Animal Science.

By: P. Bentley n & B. Grubb  n

author keywords: ZINC; RABBITS; EYES
MeSH headings : Administration, Oral; Animals; Bone and Bones / chemistry; Brain Chemistry; Eye / chemistry; Hair / chemistry; Lens, Crystalline / chemistry; Lens, Crystalline / pathology; Liver / chemistry; Male; Rabbits / growth & development; Rabbits / metabolism; Testis / chemistry; Testis / pathology; Thymus Gland / pathology; Zinc / administration & dosage; Zinc / analysis; Zinc / blood; Zinc / deficiency
topics (OpenAlex): Trace Elements in Health; Rabbits: Nutrition, Reproduction, Health; Animal Nutrition and Physiology
TL;DR: Young male New Zealand White rabbits given a diet containing 2 ppm of Zn (Zn-deficient diet) ceased to grow after 5 wk and exhibited alopecia, skin lesions, and frequent pasteurella infections, which were not observed in rabbits fed the other diets. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1986 article

Effects of melittin on a model renal epithelium, the toad urinary bladder

McGahan, M. C., Matthews, D. O., & Bentley, P. J. (1986, February 1). Biochimica Et Biophysica Acta (BBA) - Biomembranes.

By: M. McGahan n, D. Matthews n & P. Bentley n

MeSH headings : Amiloride / pharmacology; Animals; Bee Venoms / pharmacology; Bufo marinus; Epithelium / drug effects; Kidney / cytology; Lanthanum / pharmacology; Meclofenamic Acid / pharmacology; Melitten / pharmacology; Membrane Potentials / drug effects; Models, Biological; Urinary Bladder / cytology; Urinary Bladder / drug effects
topics (OpenAlex): Healthcare and Venom Research; Bee Products Chemical Analysis; Insect and Pesticide Research
TL;DR: The bee venom melittin, 10(-6) M, on the mucosal (urinary) side of the toad urinary bladder (in vitro), markedly decreased transepithelial potential difference, short-circuit current (Isc, sodium-dependent) and resistance. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1985 article

Melittin-induced changes in Na and Cl movements across the skin and cornea (in vitro) of the toad Bufo marinus

McGahan, M. C., Hazard, R. L., & Bentley, P. J. (1985, January 1). Comparative Biochemistry and Physiology Part C Comparative Pharmacology.

By: M. McGahan n, R. Hazard n & P. Bentley n

MeSH headings : Amphotericin B / pharmacology; Animals; Bee Venoms / pharmacology; Biological Transport, Active / drug effects; Bufo marinus; Bumetanide / pharmacology; Chlorides / metabolism; Cornea / drug effects; Cornea / metabolism; Meclofenamic Acid / pharmacology; Melitten / pharmacology; Quinacrine / pharmacology; Skin / drug effects; Skin / metabolism; Sodium / metabolism; Trifluoperazine / pharmacology; Vasopressins / pharmacology
topics (OpenAlex): Healthcare and Venom Research; Bee Products Chemical Analysis; Insect and Pesticide Research
TL;DR: Melittin apparently has two types of effects, one mediated by prostaglandins while the other is more direct, as shown in corneas with melittin on the inside and on the tear side of the cornea. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

1983 article

Calcium metabolism of the rabbit lens

McGahan, M. C., Chin, B., & Bentley, P. J. (1983, January 1). Experimental Eye Research.

By: M. McGahan*, B. Chin* & P. Bentley*

MeSH headings : Animals; Calcium / metabolism; Calcium-Binding Proteins / metabolism; Hydrogen-Ion Concentration; In Vitro Techniques; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Male; Osmolar Concentration; Rabbits
topics (OpenAlex): Retinal and Macular Surgery; Intraocular Surgery and Lenses; Retinal Diseases and Treatments
TL;DR: Efflux of Ca from the lens was unchanged, under experimental conditions, by metabolic inhibitors, by EGTA, verapamil, TFP and vanadate, and in the presence of metabolic inhibitors (iodoacetate plus cyanide) lenticular Ca rises. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1983 article

Some observations on the magnesium metabolism of the rabbit lens

McGahan, M. C., Chin, B., & Bentley, P. J. (1983, January 1). Experimental Eye Research.

By: M. McGahan*, B. Chin* & P. Bentley*

MeSH headings : Animals; Calcimycin / pharmacology; In Vitro Techniques; Lens Cortex, Crystalline / drug effects; Lens Nucleus, Crystalline / drug effects; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Magnesium / metabolism; Male; Osmolar Concentration; Rabbits
topics (OpenAlex): Magnesium in Health and Disease; Biomedical Research and Pathophysiology; Information Technology and Learning
TL;DR: Incubation of lenses in solutions containing EDTA or following freezing and thawing suggested that much of the Mg is present in a bound form, and adjustment of the external Mg level in the presence of A-23187 indicated that the internal 'free' Mg concentration was about 3 mM, suggesting that about 35% of the lenticular magnesium is bound. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1982 article

A pharmacological analysis of chloride transport across the amphibian cornea.

Bentley, P. J., & McGahan, M. C. (1982, April 1). The Journal of Physiology.

By: P. Bentley* & M. McGahan*

MeSH headings : 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / analogs & derivatives; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / pharmacology; Animals; Biological Transport, Active / drug effects; Bucladesine / pharmacology; Bufo marinus; Bumetanide / pharmacology; Calcimycin / pharmacology; Chlorides / metabolism; Cornea / metabolism; Dinoprostone; Epinephrine / pharmacology; In Vitro Techniques; Meclofenamic Acid / pharmacology; Models, Biological; Prostaglandins E / pharmacology; Quinacrine / pharmacology; Trifluoperazine / pharmacology
topics (OpenAlex): Glaucoma and retinal disorders; Molecular Sensors and Ion Detection; Inflammatory mediators and NSAID effects
TL;DR: Active Cl, but not Na, transport across the toad cornea was inhibited by mepacrine, which is a phospholipase A2 inhibitor; trifluoperazine, which blocks the action of calmodulin; and meclofenamic acid, which inhibits synthesis of prostaglandins. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1982 article

Stimulation of transepithelial sodium and chloride transport by ascorbic acid. Induction of Na+ channels is inhibited by amiloride

McGahan, M. C., & Bentley, P. J. (1982, July 1). Biochimica Et Biophysica Acta (BBA) - Biomembranes.

By: M. McGahan* & P. Bentley*

MeSH headings : Amiloride / pharmacology; Animals; Ascorbic Acid / pharmacology; Biological Transport, Active / drug effects; Bufo marinus; Chlorides / metabolism; Cornea / metabolism; Epithelium / drug effects; Epithelium / metabolism; Ion Channels / drug effects; Ion Channels / metabolism; Kinetics; Pyrazines / pharmacology; Sodium / metabolism
topics (OpenAlex): Ion Transport and Channel Regulation
TL;DR: The effect of ascorbic acid on Isc when it was on the aqueous humor side of the cornea could be blocked by bumetanide but that due to the vitamin's presence on the tear side was unchanged, and these effects were additive. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1981 journal article

Alpha-aminoisobutyric acid transport in the amphibian crystalline lens

Journal of Physiology (London), 34, 49–56.

By: M. McGahan & P. Bentley

Source: NC State University Libraries
Added: August 6, 2018

1981 article

Inhibition of α-aminoisobutyric acid uptake by diisothiocyanostilbenedisulphonic acid in the amphibian cornea

McGahan, M. C., & Bentley, P. J. (1981, April 1). Biochimica Et Biophysica Acta (BBA) - Biomembranes.

By: M. McGahan* & P. Bentley*

MeSH headings : 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / analogs & derivatives; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / analogs & derivatives; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / pharmacology; Alanine / metabolism; Aminoisobutyric Acids / metabolism; Animals; Biological Transport / drug effects; Bufo marinus; Cornea / metabolism; Hydrogen-Ion Concentration; Kinetics; Lens, Crystalline / metabolism; Stilbenes / pharmacology
topics (OpenAlex): Lipid Membrane Structure and Behavior; Antimicrobial Peptides and Activities; Healthcare and Venom Research
TL;DR: The inhibitory effect of diisothiocyanostilbenedisulphonic acid on aminoisobutyric acid accumulation appears to reflect a direct action on membrane mechanisms that mediate its influx. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1980 article

Inhibitory action of DIDS on chloride transport across the amphibian cornea.

Bentley, P. J., & McGahan, M. C. (1980, July 1). The Journal of Physiology.

By: P. Bentley* & M. McGahan*

MeSH headings : 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / analogs & derivatives; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / pharmacology; Animals; Biological Transport, Active / drug effects; Bufo marinus; Bumetanide / pharmacology; Chlorides / metabolism; Cornea / drug effects; Cornea / metabolism; In Vitro Techniques; Membrane Potentials / drug effects; Sodium / metabolism; Stilbenes / pharmacology
topics (OpenAlex): Corneal surgery and disorders; Ocular Surface and Contact Lens; Corneal Surgery and Treatments
TL;DR: The results are consistent with the role of a Cl‐/anion exchange mechanism in active Cl transport across the cornea and a hypothesis regarding the interactions and site of action of bumetanide in relation to that of DIDS, and the Cl transport process is proposed. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1977 journal article

The mode of action of bumetanide: inhibition of chloride transport across the amphibian cornea

Journal of Pharmacology and Experimental Therapeutics, 203, 97–102.

By: M. McGahan, T. Yorio & P. Bentley

Source: NC State University Libraries
Added: August 6, 2018

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