Sarah Carter Green

Works (1)

Updated: April 5th, 2024 10:00

2017 journal article

Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation

CANCER RESEARCH, 77(12), 3217–3230.

By: K. Tech n, A. Tikunov n, H. Farooq*, A. Morrissy*, J. Meidinger*, T. Fish*, S. Green n, H. Liu* ...

MeSH headings : Animals; Blotting, Western; Cell Proliferation; Cerebellar Neoplasms / enzymology; Cerebellar Neoplasms / pathology; Cerebellum / enzymology; Chromatography, Liquid; Humans; Immunohistochemistry; Mass Spectrometry; Medulloblastoma / enzymology; Medulloblastoma / pathology; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neural Stem Cells / enzymology; Neural Stem Cells / pathology; Neurogenesis / physiology; Polymerase Chain Reaction; Pyruvate Kinase / metabolism
TL;DR: Findings show that distal and proximal disruptions of glycolysis have opposite effects on proliferation, and that efforts to block the oncogenic effect of aerobic glyCOlysis must target reactions upstream of PKM. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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