Sriram Vasudevan Chari

Works (4)

Updated: July 5th, 2023 15:33

2022 journal article

Effects of subject-variability on nasally inhaled drug deposition, uptake, and clearance

JOURNAL OF AEROSOL SCIENCE, 165.

By: S. Chari n, K. Sridhar  n & C. Kleinstreuer n

author keywords: Nasal geometric variabilities; CF-PD analysis With updated OpenFOAM; solver; Inhaled drug-aerosol transport and uptake; Mucus layer dynamics; Mucociliary clearance; Dissolution and absorption of three generic; drugs
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Added: July 5, 2022

2021 journal article

An effective PBPK model predicting dissolved drug transfer from a representative nasal cavity to the blood stream

JOURNAL OF AEROSOL SCIENCE, 160.

By: S. Dave  n, C. Kleinstreuer n & S. Chari n

author keywords: Intranasal drugs; Hybrid CFPD-PBPK model; Disposition of inhaled drugs; Pharmacokinetic modeling; Drug concentrations in the blood stream
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Added: March 7, 2022

2021 journal article

Computational analysis of a 3D mucociliary clearance model predicting nasal drug uptake

JOURNAL OF AEROSOL SCIENCE, 155.

By: S. Chari n, K. Sridhar  n, R. Walenga* & C. Kleinstreuer n

author keywords: Mucociliary clearance; Nasal drug dissolution and absorption; CFD analysis of inhaled drug-aerosol transport; and uptake; Mucus layer dynamics; 3D modeling
TL;DR: A novel 3D meshing technique allows for the smooth capture of both the relatively large flow domain as well as the micron-size mucus layer and shows that drugs with a high partition coefficient are absorbed rapidly and drugs with higher solubility show an appreciable increase in cumulative uptake in the epithelium. (via Semantic Scholar)
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Added: June 10, 2021

2018 journal article

Convective mass and heat transfer enhancement of nanofluid streams in bifurcating microchannels

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 125, 1212–1229.

By: S. Chari n & C. Kleinstreuer n

author keywords: Microchannel mixing; Heat transfer; Pulsatile flow; Geometry optimization; Empirical correlation
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Added: October 19, 2018

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