Sriram Vasudevan Chari

Works (4)

Updated: July 5th, 2023 15:33

2022 journal article

An effective PBPK model predicting dissolved drug transfer from a representative nasal cavity to the blood stream

JOURNAL OF AEROSOL SCIENCE, 160.

By: S. Dave  n, C. Kleinstreuer n & S. Chari n

author keywords: Intranasal drugs; Hybrid CFPD-PBPK model; Disposition of inhaled drugs; Pharmacokinetic modeling; Drug concentrations in the blood stream
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 7, 2022

2022 journal article

Effects of subject-variability on nasally inhaled drug deposition, uptake, and clearance

JOURNAL OF AEROSOL SCIENCE, 165.

By: S. Chari n, K. Sridhar n & C. Kleinstreuer

author keywords: Nasal geometric variabilities; CF-PD analysis With updated OpenFOAM; solver; Inhaled drug-aerosol transport and uptake; Mucus layer dynamics; Mucociliary clearance; Dissolution and absorption of three generic; drugs
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 5, 2022

2021 journal article

Computational analysis of a 3D mucociliary clearance model predicting nasal drug uptake

JOURNAL OF AEROSOL SCIENCE, 155.

By: S. Chari n, K. Sridhar n, R. Walenga * & C. Kleinstreuer n

author keywords: Mucociliary clearance; Nasal drug dissolution and absorption; CFD analysis of inhaled drug-aerosol transport; and uptake; Mucus layer dynamics; 3D modeling
TL;DR: A novel 3D meshing technique allows for the smooth capture of both the relatively large flow domain as well as the micron-size mucus layer and shows that drugs with a high partition coefficient are absorbed rapidly and drugs with higher solubility show an appreciable increase in cumulative uptake in the epithelium. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021

2018 journal article

Convective mass and heat transfer enhancement of nanofluid streams in bifurcating microchannels

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 125, 1212–1229.

By: S. Chari n & C. Kleinstreuer n

author keywords: Microchannel mixing; Heat transfer; Pulsatile flow; Geometry optimization; Empirical correlation
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 19, 2018

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