2023 journal article

Antimicrobial Properties of Equine Stromal Cells and Platelets and Future Directions

VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 39(3), 565–578.

By: L. Pezzanite *, L. Chow *, S. Dow *, L. Goodrich *, J. Gilbertie* & L. Schnabel n

author keywords: Horse; Antimicrobial; Regenerative; Biologic; Therapies; Mesenchymal stromal cells; Platelets
TL;DR: Mechanisms by which biological therapies exert antimicrobial effects are discussed, as well as potential applications and challenges in clinical implementation in equine practice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 27, 2023

Increasing antimicrobial resistance in veterinary practice has driven the investigation of novel therapeutic strategies including regenerative and biologic therapies to treat bacterial infection. Integration of biological approaches such as platelet lysate and mesenchymal stromal cell (MSC) therapy may represent adjunctive treatment strategies for bacterial infections that minimize systemic side effects and local tissue toxicity associated with traditional antibiotics and that are not subject to antibiotic resistance. In this review, we will discuss mechanisms by which biological therapies exert antimicrobial effects, as well as potential applications and challenges in clinical implementation in equine practice.