2021 journal article

Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids

BMC BIOTECHNOLOGY, 21(1).

author keywords: Human cerebral organoids; Neurodevelopment; Agarose microwells; Microfabrication; RNAseq; Mechanobiology
MeSH headings : Brain; Cell Differentiation; Gene Expression Profiling; Humans; Organoids; Transcriptome
TL;DR: A role for spatial factors in brain region specification during hCO development is suggested and this work observed that non-spherical shapes showed signs of altered neurodevelopmental kinetics and favored the development of medial ganglionic eminence-associated brain regions and cell types over cortical regions. (via Semantic Scholar)
Source: Web Of Science
Added: October 26, 2021

Abstract