Dilara Sen

College of Engineering

Works (7)

Updated: March 10th, 2026 07:22

2025 article

A Human Angelman Syndrome Class II Pluripotent Stem Cell line with Fluorescent Paternal UBE3A Reporter

Kelkar, G. R., Stuppy, S. R., Sen, D., Yagci, Z. B., Han, L., Land, L., … Keung, A. J. (2025, July 14).

By: G. Kelkar n, S. Stuppy n, D. Sen n, Z. Yagci n, L. Han n, L. Land*, J. Hartman *, A. Keung n 

topics (OpenAlex): Genetic Syndromes and Imprinting
Sources: NC State University Libraries, NC State University Libraries
Added: November 22, 2025

2025 article

A human Angelman Syndrome class II pluripotent stem cell line with fluorescent paternal UBE3A reporter

Kelkar, G. R., Stuppy, S. R., Sen, D., Yagci, Z. B., Han, L., Land, L., … Keung, A. J. (2025, August 29). Frontiers in Cell and Developmental Biology.

By: G. Kelkar n, S. Stuppy n, D. Sen n, Z. Yagci n, L. Han n, L. Land*, J. Hartman *, A. Keung n 

topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Prenatal Screening and Diagnostics
Source: NC State University Libraries
Added: March 4, 2026

2025 article

Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoids

Estridge, R. C., Yagci, Z. B., Sen, D., Johnson, T. J., Kelkar, G. R., Ptacek, T. S., … Keung, A. J. (2025, May 30). Communications Biology, Vol. 8.

By: R. Estridge  n, Z. Yagci n, D. Sen n, T. Johnson  n, G. Kelkar n, T. Ptacek *, J. Simon, A. Keung* 

MeSH headings : Humans; Organoids / metabolism; Organoids / cytology; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Neurons / metabolism; Angelman Syndrome / genetics; Angelman Syndrome / metabolism
topics (OpenAlex): Pluripotent Stem Cells Research; Renal and related cancers; Genetics and Neurodevelopmental Disorders
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 30, 2025

2021 article

Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids

Sen, D., Voulgaropoulos, A., & Keung, A. J. (2021, October 12). BMC Biotechnology, Vol. 21.

By: D. Sen n, A. Voulgaropoulos n & A. Keung n 

author keywords: Human cerebral organoids; Neurodevelopment; Agarose microwells; Microfabrication; RNAseq; Mechanobiology
MeSH headings : Brain; Cell Differentiation; Gene Expression Profiling; Humans; Organoids; Transcriptome
topics (OpenAlex): Pluripotent Stem Cells Research; 3D Printing in Biomedical Research; Planarian Biology and Electrostimulation
TL;DR: A role for spatial factors in brain region specification during hCO development is suggested and this work observed that non-spherical shapes showed signs of altered neurodevelopmental kinetics and favored the development of medial ganglionic eminence-associated brain regions and cell types over cortical regions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 26, 2021

2021 article

Evaluation of UBE3A antibodies in mice and human cerebral organoids

Sen, D., Drobna, Z., & Keung, A. J. (2021, March 18). Scientific Reports, Vol. 11.

By: D. Sen n, Z. Drobna n & A. Keung n 

MeSH headings : Angelman Syndrome / genetics; Angelman Syndrome / pathology; Animals; Antibodies / genetics; Antibodies / immunology; Autistic Disorder / genetics; Autistic Disorder / pathology; Cerebellum / cytology; Disease Models, Animal; Genomic Imprinting; Humans; Mice; Neural Stem Cells / metabolism; Neurons / metabolism; Neurons / pathology; Organoids / cytology; Pluripotent Stem Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / immunology
topics (OpenAlex): Genetic Syndromes and Imprinting; Genetics and Neurodevelopmental Disorders; Epigenetics and DNA Methylation; Genomics and Rare Diseases
TL;DR: While four antibodies show specific localization patterns in both mouse brain sections and human cerebral organoids, these antibodies varied significantly in background signals and staining patterns in undifferentiated human pluripotent stem cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 19, 2021

2020 article

Capturing complex epigenetic phenomena through human multicellular systems

Sen, D., & Keung, A. J. (2020, June 7). Current Opinion in Biomedical Engineering, Vol. 16, pp. 34–41.

By: D. Sen n & A. Keung n 

author keywords: Epigenetics; Organoids; Development; Aging; 3D; Multicellular
topics (OpenAlex): Epigenetics and DNA Methylation; Genomics and Chromatin Dynamics; Single-cell and spatial transcriptomics
TL;DR: Recent work is highlighted that demonstrates how multicellular systems provide a natural approach to capture complex epigenetic phenomena through more closely matching the in vivo environment and through the intrinsic nature of multi-cellular systems being able to generate and model multiple distinct cellular states, all within one system. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2020 article

Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A

Sen, D., Voulgaropoulos, A., Drobna, Z., & Keung, A. J. (2020, September 10). Stem Cell Reports, Vol. 15, pp. 845–854.

By: D. Sen n, A. Voulgaropoulos n, Z. Drobna n & A. Keung n 

MeSH headings : Angelman Syndrome / pathology; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cerebrum / metabolism; Genomic Imprinting / drug effects; Humans; Neurons / drug effects; Neurons / metabolism; Organoids / drug effects; Organoids / metabolism; Time Factors; Topoisomerase Inhibitors / pharmacology; Ubiquitin-Protein Ligases / metabolism
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Tumors and Oncological Cases
TL;DR: Human cerebral organoids are established as an important model for studying UBE3A and motivates their broader use in understanding complex neurodevelopmental disorders. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 9, 2020

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