Dilara Sen

College of Engineering

Works (4)

Updated: July 5th, 2023 14:32

2021 journal article

Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids


By: D. Sen n, A. Voulgaropoulos n & A. Keung n

author keywords: Human cerebral organoids; Neurodevelopment; Agarose microwells; Microfabrication; RNAseq; Mechanobiology
MeSH headings : Brain; Cell Differentiation; Gene Expression Profiling; Humans; Organoids; Transcriptome
TL;DR: A role for spatial factors in brain region specification during hCO development is suggested and this work observed that non-spherical shapes showed signs of altered neurodevelopmental kinetics and favored the development of medial ganglionic eminence-associated brain regions and cell types over cortical regions. (via Semantic Scholar)
Source: Web Of Science
Added: October 26, 2021

2021 journal article

Evaluation of UBE3A antibodies in mice and human cerebral organoids


By: D. Sen n, Z. Drobna n & A. Keung n

MeSH headings : Angelman Syndrome / genetics; Angelman Syndrome / pathology; Animals; Antibodies / genetics; Antibodies / immunology; Autistic Disorder / genetics; Autistic Disorder / pathology; Cerebellum / cytology; Disease Models, Animal; Genomic Imprinting; Humans; Mice; Neural Stem Cells / metabolism; Neurons / metabolism; Neurons / pathology; Organoids / cytology; Pluripotent Stem Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / immunology
TL;DR: While four antibodies show specific localization patterns in both mouse brain sections and human cerebral organoids, these antibodies varied significantly in background signals and staining patterns in undifferentiated human pluripotent stem cells. (via Semantic Scholar)
Source: Web Of Science
Added: July 19, 2021

2020 review

Capturing complex epigenetic phenomena through human multicellular systems


By: D. Sen n & A. Keung n

author keywords: Epigenetics; Organoids; Development; Aging; 3D; Multicellular
TL;DR: Recent work is highlighted that demonstrates how multicellular systems provide a natural approach to capture complex epigenetic phenomena through more closely matching the in vivo environment and through the intrinsic nature of multi-cellular systems being able to generate and model multiple distinct cellular states, all within one system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 10, 2021

2020 journal article

Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A

STEM CELL REPORTS, 15(4), 845–854.

By: D. Sen n, A. Voulgaropoulos n, Z. Drobna n & A. Keung n

MeSH headings : Angelman Syndrome / pathology; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cerebrum / metabolism; Genomic Imprinting / drug effects; Humans; Neurons / drug effects; Neurons / metabolism; Organoids / drug effects; Organoids / metabolism; Time Factors; Topoisomerase Inhibitors / pharmacology; Ubiquitin-Protein Ligases / metabolism
TL;DR: Human cerebral organoids are established as an important model for studying UBE3A and motivates their broader use in understanding complex neurodevelopmental disorders. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Source: Web Of Science
Added: November 9, 2020

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