2022 article

Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase

Li, Z., Kaur, P., Lo, C.-Y., Chopra, N., Smith, J., Wang, H., & Gao, Y. (2022, November 18). NUCLEIC ACIDS RESEARCH.

By: Z. Li*, P. Kaur n, C. Lo*, N. Chopra*, J. Smith*, H. Wang n, Y. Gao*

MeSH headings : Humans; Mitochondrial Proteins / metabolism; Cryoelectron Microscopy; DNA Helicases / metabolism; Mitochondria / genetics; Mitochondria / metabolism; DNA Replication; DNA, Mitochondrial / genetics
TL;DR: Cryo-electron microscopy and high-speed atomic force microscope data obtained the atomic-resolution structure of a vertebrate Twinkle homolog with DNA and captured in real-time how Twinkle is self-loaded onto DNA, highlighting the essential role of the non-catalytic N-terminal domain of Twinkle. (via Semantic Scholar)
Source: Web Of Science
Added: December 5, 2022