Works (5)

Updated: July 5th, 2023 16:04

2000 journal article

A facilitated cyclic ether formation and its potential application in solid-phase peptide and organic synthesis

Chemical & Pharmaceutical Bulletin, 48(2), 238–244.

By: D. Shan, A. Zheng, C. Ballard, W. Wang, R. Borchardt & B. Wang

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

A redox-sensitive resin linker for the solid phase synthesis of C-terminal modified peptides

JOURNAL OF ORGANIC CHEMISTRY, 64(1), 156–161.

By: A. Zheng n, D. Shan n & B. Wang n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability

PHARMACEUTICAL RESEARCH, 16(1), 7–15.

By: O. Gudmundsson*, G. Pauletti*, W. Wang n, D. Shan n, H. Zhang n, B. Wang n, R. Borchardt*

co-author countries: United States of America 🇺🇸
author keywords: esterase-sensitive prodrugs; peptide delivery; opioid peptides; Caco-2 cells; membrane permeability; chemical and enzymatic stability
MeSH headings : Animals; Caco-2 Cells; Cell Membrane Permeability; Coumaric Acids / metabolism; Endorphins / metabolism; Enzyme Stability; Humans; Male; Molecular Sequence Data; Peptide Hydrolases / metabolism; Peptides, Cyclic / metabolism; Prodrugs; Rats; Rats, Sprague-Dawley
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers

JOURNAL OF PEPTIDE RESEARCH, 53(4), 370–382.

By: B. Wang n, K. Nimkar n, W. Wang*, H. Zhang, D. Shan*, O. Gudmundsson*, S. Gangwar*, T. Siahaan*, R. Borchardt*

co-author countries: United States of America 🇺🇸
author keywords: membrane transport; opioid peptide; physicochemical properties; prodrugs
MeSH headings : Amino Acid Sequence; Cell Membrane Permeability / drug effects; Chemical Phenomena; Chemistry, Physical; Coumaric Acids / chemistry; Enkephalin, Leucine / chemistry; Enkephalin, Leucine / pharmacology; Enkephalin, Leucine-2-Alanine / chemistry; Enkephalin, Leucine-2-Alanine / pharmacology; Esterases / metabolism; Membranes, Artificial; Models, Biological; Opioid Peptides / chemical synthesis; Opioid Peptides / chemistry; Opioid Peptides / metabolism; Peptides, Cyclic / chemical synthesis; Peptides, Cyclic / chemistry; Peptides, Cyclic / metabolism; Permeability; Phenylpropionates / chemistry; Prodrugs / chemical synthesis; Prodrugs / chemistry; Prodrugs / metabolism; Prodrugs / pharmacology; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

1997 review

Prodrug strategies based on intramolecular cyclization reactions

[Review of ]. JOURNAL OF PHARMACEUTICAL SCIENCES, 86(7), 765–767.

By: D. Shan n, M. Nicolaou*, R. Borchardt* & B. Wang n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Carbamates / chemical synthesis; Carbamates / metabolism; Coumarins / chemical synthesis; Cyclization; Humans; Lactones / chemical synthesis; Mustard Compounds / chemical synthesis; Mustard Compounds / metabolism; Prodrugs / chemical synthesis; Prodrugs / metabolism
Source: Web Of Science
Added: August 6, 2018

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