Works (5)
Updated: July 5th, 2023 16:04
2000 journal article
A facilitated cyclic ether formation and its potential application in solid-phase peptide and organic synthesis
Chemical & Pharmaceutical Bulletin, 48(2), 238–244.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
A redox-sensitive resin linker for the solid phase synthesis of C-terminal modified peptides
JOURNAL OF ORGANIC CHEMISTRY, 64(1), 156–161.
TL;DR:
A redox-sensitive resin linker is developed for the synthesis of C-terminal-modified peptides by taking advantage of a "trimethyl lock"-facilitated lactonization reaction, which allows for the ready cleavage of the linker under mild conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability
PHARMACEUTICAL RESEARCH, 16(1), 7–15.
author keywords: esterase-sensitive prodrugs; peptide delivery; opioid peptides; Caco-2 cells; membrane permeability; chemical and enzymatic stability
MeSH headings : Animals; Caco-2 Cells; Cell Membrane Permeability; Coumaric Acids / metabolism; Endorphins / metabolism; Enzyme Stability; Humans; Male; Molecular Sequence Data; Peptide Hydrolases / metabolism; Peptides, Cyclic / metabolism; Prodrugs; Rats; Rats, Sprague-Dawley
TL;DR:
The cell permeation characteristics and the chemical and enzymatic stability of coumarinic acid-based cyclic pro-drugs were evaluated andcyclic prodrugs exhibited significantly greater stability against peptidase metabolism than did [Leu5]-enkephalin and DADLE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers
JOURNAL OF PEPTIDE RESEARCH, 53(4), 370–382.
author keywords: membrane transport; opioid peptide; physicochemical properties; prodrugs
MeSH headings : Amino Acid Sequence; Cell Membrane Permeability / drug effects; Chemical Phenomena; Chemistry, Physical; Coumaric Acids / chemistry; Enkephalin, Leucine / chemistry; Enkephalin, Leucine / pharmacology; Enkephalin, Leucine-2-Alanine / chemistry; Enkephalin, Leucine-2-Alanine / pharmacology; Esterases / metabolism; Membranes, Artificial; Models, Biological; Opioid Peptides / chemical synthesis; Opioid Peptides / chemistry; Opioid Peptides / metabolism; Peptides, Cyclic / chemical synthesis; Peptides, Cyclic / chemistry; Peptides, Cyclic / metabolism; Permeability; Phenylpropionates / chemistry; Prodrugs / chemical synthesis; Prodrugs / chemistry; Prodrugs / metabolism; Prodrugs / pharmacology; Structure-Activity Relationship
TL;DR:
The enhanced cellular permeation of the cyclic prodrugs is apparently due to the alteration of their lipophilicity and hydrogen bonding potential, but not their molecular sizes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 review
Prodrug strategies based on intramolecular cyclization reactions
[Review of ]. JOURNAL OF PHARMACEUTICAL SCIENCES, 86(7), 765–767.
MeSH headings : Animals; Carbamates / chemical synthesis; Carbamates / metabolism; Coumarins / chemical synthesis; Cyclization; Humans; Lactones / chemical synthesis; Mustard Compounds / chemical synthesis; Mustard Compounds / metabolism; Prodrugs / chemical synthesis; Prodrugs / metabolism
TL;DR:
Several new prodrug systems for amines, alcohols, and peptides are reviewed, which takes advantage of several facile intramolecular cyclization reactions, that permit separate manipulation of the release kinetics independent of the structural features of the drug moiety.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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