Works (2)

Updated: July 5th, 2023 15:52

2009 journal article

A Regression-based Association Test for Case-control Studies that Uses Inferred Ancestral Haplotype Similarity


By: Y. Liu n, Y. Li*, G. Satten*, A. Allen* & J. Tzeng n

author keywords: Case-control studies; haplotype similarity; haplotype sharing; haplotype-based association test; covariates; regression-based association analysis
MeSH headings : Case-Control Studies; Computer Simulation; Gene Frequency; Genetic Techniques; Genome, Human; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic; Polymorphism, Single Nucleotide; Regression Analysis
TL;DR: A new regression‐based HS association method for case‐control studies that incorporates covariate information and combines the advantages of the two classes of approaches by using inferred ancestral haplotypes is proposed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study

GENETICS IN MEDICINE, 10(10), 720–729.

By: I. Grossman*, P. Sullivan*, N. Walley*, Y. Liu n, J. Dawson*, C. Gumbs*, A. Gaedigk*, J. Leeder* ...

author keywords: pharmacogenetics; CYP 450; drug metabolizing enzymes; antipsychotics; personalized medicine
MeSH headings : Adult; Antipsychotic Agents / adverse effects; Antipsychotic Agents / metabolism; Antipsychotic Agents / therapeutic use; Clinical Trials as Topic; Double-Blind Method; Female; Genetic Variation; Humans; Male; Middle Aged; Schizophrenia / drug therapy
TL;DR: There are no strong associations between common functional genetic variants in drug metabolizing enzymes and dosing, safety, or efficacy of leading antipsychotics, strongly suggesting merely modest effects on the use of these medicines in most patients in typical clinical settings. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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