Recent Works

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Sorted by most recent date added to the index first, which may not be the same as publication date order.

2025 article

Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model

Song, Z., Tryndyak, V. P., Willett, R. A., Pogribny, I. P., Rusyn, I., & Wright, F. A. (2025, August 28). TOXICOLOGICAL SCIENCES.

author keywords: liver; steatohepatitis; fibrosis
topics (OpenAlex): Liver Disease Diagnosis and Treatment; Hepatitis B Virus Studies; Endoplasmic Reticulum Stress and Disease
Source: Web Of Science
Added: September 8, 2025

2025 journal article

Two-body triton photodisintegration and Wigner-SU(4) symmetry

PHYSICAL REVIEW C, 112(2).

By: X. Lin & J. Vanasse

topics (OpenAlex): Molecular spectroscopy and chirality; Advanced Chemical Physics Studies
Sources: Web Of Science, NC State University Libraries
Added: August 25, 2025

2025 article

Active regulation of the epidermal growth factor receptor by the membrane bilayer

Srinivasan, S., Lin, X., Chen, X., Regmi, R., Zhang, B., & Schlau-Cohen, G. S. (2025, August 18).

By: S. Srinivasan, X. Lin*, X. Chen, R. Regmi, B. Zhang & G. Schlau-Cohen

topics (OpenAlex): Monoclonal and Polyclonal Antibodies Research; HER2/EGFR in Cancer Research
Source: ORCID
Added: August 19, 2025

2025 article

Genomic Evaluation of Canine Prostatic Carcinomas as a Model for the Human Disease

Thomas, R., Luff, J. A., Dickey, A. N., Dillon, M. N., Livingston, I. G., Schrag, C. A., … Breen, M. (2025, July 23). VETERINARY AND COMPARATIVE ONCOLOGY, Vol. 7.

By: R. Thomas n, J. Luff n, A. Dickey n, M. Dillon n, I. Livingston n, C. Schrag n, S. Suter n, M. Breen n

author keywords: adenocarcinoma; DNA copy number variations; dogs; mutation; prostatic neoplasms; urologic neoplasms
topics (OpenAlex): Veterinary Oncology Research; Veterinary Medicine and Surgery; Human-Animal Interaction Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 28, 2025

2025 journal article

Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits

GENOME RESEARCH, 35(7), 1485–1502.

MeSH headings : Humans; Quantitative Trait Loci; Liver / metabolism; Chromatin / genetics; Chromatin / metabolism; Genome-Wide Association Study; Gene Expression Regulation; Transcription Factors / metabolism; Binding Sites; Polymorphism, Single Nucleotide
topics (OpenAlex): Epigenetics and DNA Methylation; Genomics and Chromatin Dynamics; Genetics and Neurodevelopmental Disorders
Source: Web Of Science
Added: July 21, 2025

2025 journal article

Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice☆

TOXICOLOGY AND APPLIED PHARMACOLOGY, 502.

co-author countries: Canada 🇨🇦
author keywords: Mice; MASH; Liver Pathology; Transcriptomics; Machine Leaning Pathologist Assistance
MeSH headings : Animals; Male; Female; Mice; Disease Models, Animal; Diet, High-Fat / adverse effects; Liver / pathology; Liver / metabolism; Transcriptome; Gene Expression Profiling / methods; Collaborative Cross Mice; Fatty Liver / genetics; Fatty Liver / pathology; Fatty Liver / metabolism; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / pathology
topics (OpenAlex): Liver Disease Diagnosis and Treatment; Endoplasmic Reticulum Stress and Disease; Hepatocellular Carcinoma Treatment and Prognosis
Source: Web Of Science
Added: July 21, 2025

2025 journal article

Interpretable protein-DNA interactions captured by structure-sequence optimization

ELife.

By: Y. Zhang n, I. Silvernail n, Z. Lin n & X. Lin n

topics (OpenAlex): RNA and protein synthesis mechanisms; Genomics and Chromatin Dynamics; DNA and Nucleic Acid Chemistry
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: July 17, 2025

2025 journal article

Conditional knockout of C/EBPβ in epidermis results in dysregulated lipid biosynthesis and a defect in skin barrier function

PLOS ONE, 20(6).

By: K. Mills n, M. Doyle n, J. House n, J. Witherspoon n, D. Krakko n, W. Stutts n, J. Chappel n, J. Hall n, E. Baker n, R. Smart n

Ed(s): S. Raza

MeSH headings : Animals; Epidermis / metabolism; Mice; Mice, Knockout; Lipid Metabolism / genetics; Lipids / biosynthesis; CCAAT-Enhancer-Binding Proteins / genetics; CCAAT-Enhancer-Binding Proteins / metabolism; Keratinocytes / metabolism; Lipogenesis / genetics; Lipidomics
topics (OpenAlex): melanin and skin pigmentation; Retinoids in leukemia and cellular processes; Plant Molecular Biology Research
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 25, 2025

2025 journal article

Characterizing DNA recognition preferences of transcription factors using global couplings and high-throughput sequencing

NUCLEIC ACIDS RESEARCH, 53(12).

topics (OpenAlex): Genomics and Chromatin Dynamics; RNA and protein synthesis mechanisms; RNA Research and Splicing
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 15, 2025

2025 journal article

HAP-SAMPLE2: data-based resampling for association studies with admixture

BIOINFORMATICS, 41(6).

By: G. Sun n, B. Ting n, F. Wright n & Y. Zhou n

Ed(s): J. Kelso

topics (OpenAlex): Data Mining Algorithms and Applications
Sources: ORCID, Web Of Science
Added: June 11, 2025

2025 article

Interpretable Protein-DNA Interactions Captured by Structure-Sequence Optimization

Zhang, Y., Silvernail, I., Lin, Z., & Lin, X. (2025, June 9).

By: Y. Zhang n, I. Silvernail n, Z. Lin n & X. Lin n

topics (OpenAlex): RNA and protein synthesis mechanisms; Genomics and Chromatin Dynamics; RNA modifications and cancer
Source: ORCID
Added: June 9, 2025

2025 journal article

Asian diversity in human immune cells

CELL, 188(8).

By: K. Kock*, L. Tan*, K. Han*, Y. Ando*, D. Jevapatarakul*, A. Chatterjee, Q. Lin*, E. Buyamin* ...

co-author countries: India 🇮🇳 Italy 🇮🇹 Japan 🇯🇵 Korea (Republic of) 🇰🇷 Singapore 🇸🇬 Thailand 🇹🇭
MeSH headings : Humans; Asian People / genetics; Single-Cell Analysis; Female; Male; Genetic Variation; Asia; Adult; Middle Aged
topics (OpenAlex): Immune Cell Function and Interaction; Immune responses and vaccinations; T-cell and B-cell Immunology
Source: Web Of Science
Added: May 27, 2025

2025 journal article

The integration of quantitative trait locus mapping and transcriptome studies reveals candidate genes for water stress response in St. Augustinegrass

BMC Plant Biology, 25(1).

author keywords: QTL mapping; Transcriptome; Drought stress; St. Augustinegrass
MeSH headings : Quantitative Trait Loci / genetics; Chromosome Mapping; Transcriptome; Droughts; Genes, Plant; Gene Expression Profiling; Polymorphism, Single Nucleotide; Stress, Physiological / genetics; Genotype
topics (OpenAlex): Turfgrass Adaptation and Management; Plant and Fungal Interactions Research; Plant Disease Resistance and Genetics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 27, 2025

2025 journal article

Profiling the Tox21 Compound Library for Their Inhibitory Effects on Cytochrome P450 Enzymes

International Journal of Molecular Sciences.

MeSH headings : Cytochrome P-450 Enzyme Inhibitors / pharmacology; Cytochrome P-450 Enzyme Inhibitors / chemistry; Humans; Cytochrome P-450 Enzyme System / metabolism; Cytochrome P-450 Enzyme System / chemistry; Small Molecule Libraries / pharmacology; Small Molecule Libraries / chemistry
topics (OpenAlex): Pharmacogenetics and Drug Metabolism; Cancer Treatment and Pharmacology; Computational Drug Discovery Methods
Source: ORCID
Added: May 22, 2025

2025 article

A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets

Tsai, H.-H. D., Oware, K. D., Wright, F. A., Chiu, W. A., & Rusyn, I. (2025, April 3). TOXICOLOGICAL SCIENCES.

author keywords: transcriptomics; key characteristics; gene set enrichment; gene expression
topics (OpenAlex): Computational Drug Discovery Methods; Carcinogens and Genotoxicity Assessment; Gene expression and cancer classification
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 14, 2025

2025 article

Co-occurrence drives horizontal gene transfer among marine prokaryotes

Douglas, G. M., Tromas, N., Gaudin, M., Lypaczewksi, P., Bobay, L.-M., Shapiro, B. J., & Chaffron, S. (2025, March 28).

By: G. Douglas, N. Tromas, M. Gaudin, P. Lypaczewksi, L. Bobay*, B. Shapiro, S. Chaffron

topics (OpenAlex): Microbial Community Ecology and Physiology; Bacteriophages and microbial interactions; Polar Research and Ecology
Source: ORCID
Added: April 1, 2025

2025 journal article

Integrating AI-powered text mining from PubTator into the manual curation workflow at the Comparative Toxicogenomics Database

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2025.

MeSH headings : Toxicogenetics; Data Mining / methods; Data Curation / methods; Humans; Databases, Factual; Workflow; Databases, Genetic
topics (OpenAlex): Biomedical Text Mining and Ontologies; Genetics, Bioinformatics, and Biomedical Research; Bioinformatics and Genomic Networks
Sources: Web Of Science, NC State University Libraries
Added: March 10, 2025

2025 article

Connected Chromatin Amplifies Acetylation-Modulated Nucleosome Interactions

Li, R., & Lin, X. (2025, March 3). BIOCHEMISTRY, Vol. 3.

By: R. Li n & X. Lin n

co-author countries: Japan 🇯🇵
MeSH headings : Nucleosomes / metabolism; Nucleosomes / chemistry; Acetylation; Histones / metabolism; Histones / chemistry; Chromatin / metabolism; Chromatin / chemistry; Protein Processing, Post-Translational; DNA / metabolism; DNA / chemistry; Molecular Dynamics Simulation; Humans; Chromatin Assembly and Disassembly
topics (OpenAlex): Genomics and Chromatin Dynamics; RNA Research and Splicing; DNA and Nucleic Acid Chemistry
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 3, 2025

2025 journal article

Zebrafish Cyp1b1 knockout alters eye and brain metabolomic profiles, affecting ocular and neurobehavioral function

TOXICOLOGY AND APPLIED PHARMACOLOGY, 496.

author keywords: Cytochrome P450; Untargeted metabolomics; Mutliomics; Zebrafish; Eye disorders
MeSH headings : Animals; Zebrafish / genetics; Cytochrome P-450 CYP1B1 / genetics; Cytochrome P-450 CYP1B1 / metabolism; Brain / metabolism; Behavior, Animal; Eye / metabolism; Metabolomics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism; Larva; Gene Knockout Techniques; Reflex, Startle; Metabolome
topics (OpenAlex): Zebrafish Biomedical Research Applications; Metabolomics and Mass Spectrometry Studies; Eicosanoids and Hypertension Pharmacology
Source: Web Of Science
Added: March 3, 2025

2025 article

Examining risk assessment implications of genetic and dose-dependent dynamics of lead exposure in breastfeeding using the collaborative cross mouse population

Cuomo, D., Song, Z., Nitcher, M., Lynch, R., Barba, E., Feinberg, A. P., … Threadgill, D. W. (2025, February 11). TOXICOLOGICAL SCIENCES.

author keywords: lead; risk assessment; mouse model; maternal exposure
MeSH headings : Animals; Female; Risk Assessment; Lead / toxicity; Lead / blood; Dose-Response Relationship, Drug; Breast Feeding; Collaborative Cross Mice; Lactation; Mice; Pregnancy; Maternal Exposure / adverse effects; Male
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Animal Behavior and Welfare Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 24, 2025

2025 article

Interpretable Protein-DNA Interactions Captured by Structure-Sequence Optimization

Zhang, Y., Silvernail, I., Lin, Z., & Lin, X. (2025, February 7).

By: Y. Zhang n, I. Silvernail n, Z. Lin n & X. Lin n

topics (OpenAlex): RNA and protein synthesis mechanisms; Genomics and Chromatin Dynamics; Protein Structure and Dynamics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: February 7, 2025

2025 journal article

Interpretable protein-DNA interactions captured by structure-sequence optimization

ELIFE, 14.

By: Y. Zhang n, I. Silvernail n, Z. Lin n & X. Lin n

MeSH headings : DNA / metabolism; DNA / chemistry; Protein Binding; DNA-Binding Proteins / metabolism; DNA-Binding Proteins / chemistry; Binding Sites; Models, Molecular; Thermodynamics
topics (OpenAlex): RNA and protein synthesis mechanisms; Genomics and Chromatin Dynamics; Protein Structure and Dynamics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 7, 2025

2025 article

Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry

Boatman, A. K., Chappel, J. R., Kirkwood-Donelson, K. I., Fleming, J. F., Reif, D. M., Schymanski, E. L., … Baker, E. S. (2025, January 28).

By: A. Boatman*, J. Chappel*, K. Kirkwood-Donelson, J. Fleming, D. Reif*, E. Schymanski*, J. Rager*, E. Baker*

co-author countries: Luxembourg 🇱🇺
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Hemoglobin structure and function; Methemoglobinemia and Tumor Lysis Syndrome; Health, Environment, Cognitive Aging
Source: ORCID
Added: January 28, 2025

2025 journal article

Bayesian analysis of the rate of spontaneous malignant mesothelioma among <i>BAP1</i> mutant mice in the absence of asbestos exposure

SCIENTIFIC REPORTS, 15(1).

By: D. Nielsen n, M. Hsu*, M. Zapata III, G. Ciavarra & L. Zyl*

author keywords: Mesothelioma; Asbestos; BAP1; Mouse studies; Historical control data; Bayesian statistics
MeSH headings : Animals; Ubiquitin Thiolesterase / genetics; Mice; Asbestos / toxicity; Asbestos / adverse effects; Bayes Theorem; Mesothelioma, Malignant / genetics; Mesothelioma, Malignant / pathology; Tumor Suppressor Proteins / genetics; Germ-Line Mutation; Lung Neoplasms / genetics; Lung Neoplasms / pathology; Lung Neoplasms / chemically induced
topics (OpenAlex): Occupational and environmental lung diseases; Carcinogens and Genotoxicity Assessment
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2025 journal article

Bayesian gene set benchmark dose estimation for “omic” responses

Bioinformatics.

Ed(s): C. Kendziorski

MeSH headings : Animals; Rats; Bayes Theorem; Benchmarking; Gene Expression Profiling / methods; Transcriptome
topics (OpenAlex): Animal testing and alternatives; Computational Drug Discovery Methods; Carcinogens and Genotoxicity Assessment
Source: ORCID
Added: January 7, 2025

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