Kwan-Seob Shim

author keywords: acetate; anaplerosis; carnitine palmitoyltransferase I activity; ketone bodies; mitochondria; Sus scrofa

MeSH headings : Acetates / metabolism; Acetyl-CoA Hydrolase / metabolism; Age Factors; Animals; Animals, Suckling; Carbon Radioisotopes; Carnitine O-Palmitoyltransferase / genetics; Carnitine O-Palmitoyltransferase / metabolism; Citric Acid / metabolism; Citric Acid Cycle / physiology; Enzyme Activation / physiology; Fatty Acids / metabolism; Gene Expression Regulation, Enzymologic; Ketone Bodies / metabolism; Liver / enzymology; Malonyl Coenzyme A / metabolism; Mitochondria / metabolism; Mitochondria, Liver / enzymology; Oxidation-Reduction; Palmitates / pharmacokinetics; Palmitoyl Coenzyme A / metabolism; RNA, Messenger / metabolism; Sus scrofa / metabolism

topics (OpenAlex): Metabolism and Genetic Disorders; Liver Disease Diagnosis and Treatment; Muscle metabolism and nutrition

TL;DR: It is demonstrated that acetate is the primary product of hepatic mitochondrial beta-oxidation in Sus scrofa and that regulation during early development is mediated primarily via kinetic modulation of CPT I. (via Semantic Scholar)

MeSH headings : Animals; Carnitine / administration & dosage; Carnitine / metabolism; Carnitine O-Palmitoyltransferase / metabolism; Dietary Supplements; Energy Metabolism / drug effects; Female; Fetus / metabolism; Kinetics; Liver / enzymology; Maternal-Fetal Exchange; Myocardium / enzymology; Pregnancy; Pyruvate Dehydrogenase Complex / metabolism; Swine

topics (OpenAlex): Metabolism and Genetic Disorders; Folate and B Vitamins Research; Diet and metabolism studies

TL;DR: Carnitine ingestion during pregnancy increases fetal carnitine concentrations and stimulates heart PDHC and liver CPT activity without altering Carnitine K(m). (via Semantic Scholar)