Richard W. Morris

author keywords: acute renal failure (ARF); polymorphism; genetic; postoperative; intensive care; cardiopulmonary bypass (CPB); heart surgery; cardiac surgery; human; angiotensin-converting enzyme (ACE); associate study; candidate genes

MeSH headings : Acute Kidney Injury / blood; Acute Kidney Injury / epidemiology; Acute Kidney Injury / ethnology; Acute Kidney Injury / genetics; Black or African American / genetics; Aged; Alleles; Angiotensins / genetics; Apolipoproteins E / genetics; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / surgery; Coronary Artery Bypass; Creatinine / blood; Cytokines / genetics; DNA Mutational Analysis; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase Type III; North Carolina / epidemiology; Polymorphism, Genetic; Postoperative Complications / epidemiology; Prospective Studies; Pulmonary Disease, Chronic Obstructive / epidemiology; Receptor, Angiotensin, Type 1 / genetics; Risk; White People / genetics

TL;DR: It is identified that genetic polymorphisms that collectively provide 2- to 4-fold improvement over preoperative clinical factors alone in explaining post-cardiac surgery renal dysfunction are associated with increased renal inflammatory and/or vasoconstrictor responses. (via Semantic Scholar)

author keywords: fine mapping; linkage disequilibrium; association test; TDT; coalescent process

MeSH headings : Case-Control Studies; Chi-Square Distribution; Chromosome Mapping; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic

TL;DR: A simple strategy of choosing the marker with the smallest associated P value to begin a laboratory search for the disease locus performs adequately for a common disease allele, and a strategy of pooling nearby sites to form multiple allele markers is investigated. (via Semantic Scholar)