2005 journal article

Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery

American Journal of Kidney Diseases, 45(3), 519–530.

By: M. Stafford-Smith*, M. Podgoreanu*, M. Swaminathan*, B. Phillips-Bute*, J. Mathew*, E. Hauser*, M. Winn*, C. Milano* ...

author keywords: acute renal failure (ARF); polymorphism; genetic; postoperative; intensive care; cardiopulmonary bypass (CPB); heart surgery; cardiac surgery; human; angiotensin-converting enzyme (ACE); associate study; candidate genes
MeSH headings : Acute Kidney Injury / blood; Acute Kidney Injury / epidemiology; Acute Kidney Injury / ethnology; Acute Kidney Injury / genetics; Black or African American / genetics; Aged; Alleles; Angiotensins / genetics; Apolipoproteins E / genetics; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / surgery; Coronary Artery Bypass; Creatinine / blood; Cytokines / genetics; DNA Mutational Analysis; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase Type III; North Carolina / epidemiology; Polymorphism, Genetic; Postoperative Complications / epidemiology; Prospective Studies; Pulmonary Disease, Chronic Obstructive / epidemiology; Receptor, Angiotensin, Type 1 / genetics; Risk; White People / genetics
TL;DR: It is identified that genetic polymorphisms that collectively provide 2- to 4-fold improvement over preoperative clinical factors alone in explaining post-cardiac surgery renal dysfunction are associated with increased renal inflammatory and/or vasoconstrictor responses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2001 journal article

Issues concerning association studies for fine mapping a susceptibility gene for a complex disease


By: N. Kaplan* & R. Morris n

author keywords: fine mapping; linkage disequilibrium; association test; TDT; coalescent process
MeSH headings : Case-Control Studies; Chi-Square Distribution; Chromosome Mapping; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic
TL;DR: A simple strategy of choosing the marker with the smallest associated P value to begin a laboratory search for the disease locus performs adequately for a common disease allele, and a strategy of pooling nearby sites to form multiple allele markers is investigated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Nonparametric step-down test procedures for finding minimum effective dose

Journal of Biopharmaceutical Statistics, 9(2), 217–240.

By: K. Sidik & R. Morris

Source: NC State University Libraries
Added: August 6, 2018

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