Sarah B. Kennett

MeSH headings : Amino Acids / chemistry; Animals; Binding, Competitive; Cell Line; Cell Nucleus / metabolism; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drosophila; Gene Expression; Genes, MDR / genetics; Humans; Insecta; Mutagenesis, Site-Directed; Mutation; Plasmids / metabolism; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Structure, Tertiary; Proto-Oncogene Proteins p21(ras) / genetics; Sequence Analysis, DNA; Sp3 Transcription Factor; Tetrahydrofolate Dehydrogenase / genetics; Time Factors; Transcription Factors / genetics; Transcription Factors / metabolism; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured

TL;DR: Biochemical and functional analyses of mutated proteins indicate that functions encoded by the M2 carboxyl terminus, such as DNA binding activity and the capacity to form multimeric complexes, are not required or sufficient for transcriptional repression. (via Semantic Scholar)