2005 journal article

Diels-alder reactions of N-acyl-2-alkyl(aryl)-5-vinyl-2,3-dihydro-4-pyridones

JOURNAL OF ORGANIC CHEMISTRY, 70(13), 5221–5234.

By: D. Comins n, J. Kuethe n, T. Miller n, F. Fevrier n & C. Brooks n

MeSH headings : Alcohols / chemical synthesis; Amino Acids / chemical synthesis; Combinatorial Chemistry Techniques; Cyclization; Ketones / chemical synthesis; Molecular Structure; Pyridones / chemistry; Stereoisomerism
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Addition of indolyl and pyrrolyl grignard reagents to 1-acylpyridinium salts

JOURNAL OF ORGANIC CHEMISTRY, 69(8), 2863–2866.

By: J. Kuethe n & D. Comins n

MeSH headings : Indicators and Reagents; Indoles / chemistry; Molecular Structure; Organometallic Compounds / chemistry; Pyridinium Compounds / chemical synthesis; Pyridinium Compounds / chemistry; Pyrroles / chemistry; Stereoisomerism
TL;DR: Indolyl and pyrrolyl Grignard reagents add to 1-acyl salts of 4-methoxy-3-(triisopropylsilyl)pyridine to give the corresponding 1-ACYl-2-heteroaryl-2,3-dihydro-4-pyridones in good to high yield. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Asymmetric total synthesis of (+)-cannabisativine

JOURNAL OF ORGANIC CHEMISTRY, 69(16), 5219–5231.

By: J. Kuethe n & D. Comins n

MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Cannabinoids / chemical synthesis; Cannabinoids / chemistry; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Organometallic Compounds; Pyridinium Compounds; Stereoisomerism
TL;DR: Several approaches to the macrocyclic ring closure of the 13-membered ring were investigated, ultimately leading to the completion of an asymmetric synthesis of the target compound with a high degree of stereocontrol. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Diels-Alder reactions of 5-vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones: regio- and stereoselective synthesis of octahydroquinolines

ORGANIC LETTERS, 5(3), 321–323.

By: J. Kuethe n, C. Brooks n & D. Comins n

MeSH headings : Molecular Structure; Pyridones / chemistry; Quinolines / chemical synthesis; Quinolines / chemistry; Stereoisomerism
TL;DR: Readily available 5-vinyldihydropyridones 2 undergo Diels-Alder cyclization with various dienophiles to afford novel octahdroquinolines to afford heterocyclic products containing synthetically useful functionality. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Tandem Diels-Alder cyclization/aromatization reactions of 5-vinyl-1-acyl-2-aryl-2,3-dihydro-4-pyridones

TETRAHEDRON LETTERS, 44(22), 4179–4182.

By: J. Kuethe n & D. Comins n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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