Works (7)
Updated: July 5th, 2023 16:03
2003 journal article
Pancreatic triacylglycerol lipase in a hibernating mammal. I. Novel genomic organization
PHYSIOLOGICAL GENOMICS, 16(1), 119–130.
author keywords: endogenous retrovirus; retroviral insertion; hibernation; promoter; genome
MeSH headings : Adipose Tissue / metabolism; Animals; Base Sequence; Blotting, Southern; Cloning, Molecular; DNA, Complementary / genetics; Endogenous Retroviruses / genetics; Evolution, Molecular; Genome, Viral; Genomic Library; Genomics; Hibernation / genetics; Humans; Lipase / genetics; Molecular Sequence Data; Mutagenesis, Insertional; Myocardium / metabolism; Pancreas / enzymology; RNA Splice Sites / genetics; RNA, Messenger / analysis; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Sciuridae / genetics; Sequence Analysis, DNA; Terminal Repeat Sequences / genetics
TL;DR:
Examination of PTL genomic clones isolated from a thirteen-lined ground squirrel genomic DNA library, coupled with genomic Southern blot analysis, enabled us to conclude that PTL mRNAs expressed in heart and WAT are the products of the same single-copy gene.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Pancreatic triacylglycerol lipase in a hibernating mammal. II. Cold-adapted function and differential expression
PHYSIOLOGICAL GENOMICS, 16(1), 131–140.
author keywords: lipolysis; low temperature; colipase; hibernation
MeSH headings : Adipose Tissue / enzymology; Adipose Tissue / metabolism; Animals; Blotting, Western; Cold Temperature; Colipases / genetics; DNA, Complementary / genetics; Gene Expression Profiling; Hibernation / genetics; Humans; Lipase / genetics; Lipase / metabolism; Male; Molecular Sequence Data; Myocardium / enzymology; Myocardium / metabolism; Organ Specificity; Pichia / genetics; RNA, Messenger / analysis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sciuridae / genetics; Seasons; Testis / enzymology; Testis / metabolism
TL;DR:
The studies indicate that low-temperature lipolysis is a general property of PTL and does not require protein modifications unique to mammalian cells and/or the hibernating state.
(via Semantic Scholar)
open access via physiolgenomics.physiology.org (publisher PDF)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal
PHYSIOLOGICAL GENOMICS, 8(1), 5–13.
author keywords: hibernation; pyruvate dehydrogenase kinase isoenzyme 4; insulin; peroxisome proliferator-activated receptor-alpha Spermophilus tridecemlineatus
MeSH headings : Adipose Tissue / chemistry; Adipose Tissue / enzymology; Adipose Tissue / physiology; Animals; Animals, Wild; Blotting, Western; Energy Metabolism / genetics; Energy Metabolism / physiology; Gene Expression Regulation / physiology; Heart / physiology; Hibernation / genetics; Hibernation / physiology; Immune Sera / metabolism; Isoenzymes / analysis; Isoenzymes / genetics; Isoenzymes / immunology; Isoenzymes / physiology; Molecular Sequence Data; Muscle, Skeletal / chemistry; Muscle, Skeletal / enzymology; Muscle, Skeletal / physiology; Myocardium / chemistry; Myocardium / enzymology; Protein Kinases / analysis; Protein Kinases / genetics; Protein Kinases / immunology; Protein Kinases / physiology; Rats; Sciuridae
TL;DR:
Examination of expression of the PDK4 gene during hibernation in heart, skeletal muscle, and white adipose tissue of the Spermophilus tridecemlineatus suggests a common signal that regulatesPDK4 expression and fuel selection During hibernation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Expression of a chimeric retroviral-lipase mRNA confers enhanced lipolysis in a hibernating mammal
American Journal of Physiology, 281(4), R1186–1192.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice
American Journal of Physiology, 278(2 pt.2), R320–330.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
A feedback loop coupling 5 S rRNA synthesis to accumulation of a ribosomal protein
JOURNAL OF BIOLOGICAL CHEMISTRY, 274(47), 33198–33201.
MeSH headings : Animals; Feedback; RNA, Ribosomal, 5S / biosynthesis; Ribosomal Proteins / metabolism; Xenopus
TL;DR:
The results support a model in which a network of nucleic acid-protein interactions involving 5 S rRNA, the 5S rRNA gene, TFIIIA, and L5 mediates both feedback inhibition of 5 S sRNA synthesis and coupling of5 S r RNA synthesis to accumulation of a ribosomal protein, L5, and propose that these mechanisms contribute to the homeostatic control of ribosome assembly.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(14), 8392–8397.
MeSH headings : Animals; Carbon / metabolism; Cloning, Molecular; DNA, Complementary / analysis; DNA, Complementary / genetics; Gene Expression Regulation / physiology; Hibernation / physiology; Molecular Sequence Data; Myocardium / metabolism; Sciuridae; Temperature
TL;DR:
A differential gene expression screen is used to identify genes that are responsible for the physiological characteristics of hibernation in the heart of the thirteen-lined ground squirrel and reports that genes for pancreatic lipase and pyruvate dehydrogenase kinase isozyme 4 are up-regulated in theheart during hibernation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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