Works (6)
Updated: July 11th, 2023 16:55
2011 journal article
Gap junctions in IL-1 beta-mediated cell survival response to strain
Journal of Applied Physiology, 110(5), 1425–1431.
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Modulation of collagen gel compaction by extracellular ATP is MAPK and NF-kappa B pathways dependent
EXPERIMENTAL CELL RESEARCH, 315(11), 1990–2000.
author keywords: ATP; Collagen gel; P2 receptor; bone; NF-kappa B; MAPK; Prestress
MeSH headings : 3T3 Cells; Adenosine Triphosphate / metabolism; Adenosine Triphosphate / pharmacology; Adenylyl Cyclases / metabolism; Animals; Base Sequence; Calmodulin / metabolism; Collagen / genetics; Collagen / metabolism; DNA Primers / genetics; Extracellular Fluid / metabolism; Gels; Gene Expression / drug effects; Kinetics; MAP Kinase Signaling System; Mechanotransduction, Cellular; Mice; Models, Biological; Myosin-Light-Chain Kinase / metabolism; NF-kappa B / metabolism; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / metabolism; Phosphatidylinositol 3-Kinases / metabolism; Receptors, Purinergic P2 / metabolism; Stress, Mechanical
TL;DR:
The results from the present and previous studies indicate that extracellular ATP may act as a negative feedback modulator in the mechanotransduction system since mechanical stimuli increase ATP release from stimulated cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Nuclear localization of the titin Z1Z2Zr domain and role in regulating cell proliferation
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 295(4), C975–C985.
author keywords: Wnt; catenin; osteoblast
MeSH headings : Active Transport, Cell Nucleus; Animals; Cell Line; Cell Proliferation; Chlorocebus aethiops; Connectin; Cricetinae; Gene Expression Regulation / physiology; Gene Silencing; Humans; Mice; Muscle Proteins / chemistry; Muscle Proteins / genetics; Muscle Proteins / metabolism; Protein Kinases / chemistry; Protein Kinases / genetics; Protein Kinases / metabolism; Protein Structure, Tertiary; Wnt Proteins / metabolism; alpha Catenin / metabolism; beta Catenin / metabolism
TL;DR:
The data implicate a dual role for titin's amino terminal region, i.e., a novel nuclear function promoting cell division in addition to its known structural role in Z-line assembly.
(via Semantic Scholar)
open access via ajpcell.physiology.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
ATP reduces gel compaction in osteoblast-populated collagen gels
JOURNAL OF APPLIED PHYSIOLOGY, 102(3), 1152–1160.
author keywords: adenosine triphosphate; three-dimensional culture; purinoceptor; osteoblast; extracellular matrix
MeSH headings : Adenosine Triphosphate / metabolism; Adenosine Triphosphate / physiology; Animals; Biomechanical Phenomena; Bone Remodeling / physiology; Cell Adhesion; Cell Culture Techniques; Cell Line; Cell Survival; Collagen Type I; Extracellular Fluid; Gene Expression Profiling; Hydrolysis; Kinetics; Mice; Nucleotides / physiology; Osteoblasts / physiology; Receptors, Purinergic P2 / physiology; Stress, Mechanical
TL;DR:
A potential role for P2 receptors in matrix remodeling and repair and as a potential drug target in treatment of bone diseases is suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Connexin 43 is localized with actin in tenocytes
CELL MOTILITY AND THE CYTOSKELETON, 64(2), 121–130.
author keywords: cyclic strain; cytoskeleton; gap junctions; tendon; myosin II
MeSH headings : Actin Cytoskeleton / metabolism; Actins / analysis; Actins / metabolism; Adult; Animals; Birds; COS Cells; Cells, Cultured; Child, Preschool; Chlorocebus aethiops; Connexin 43 / analysis; Connexin 43 / metabolism; Female; Fibroblasts / chemistry; Gap Junctions / chemistry; Gap Junctions / metabolism; Humans; Male; Middle Aged; Myosin Type II / metabolism; Stress, Mechanical; Tendons / chemistry; Tendons / cytology
TL;DR:
Connexin 43 (Cx43) may associate with actin to stabilize gap junctions at the plasma membrane, ensuring that tenocytes remain coupled during periods of prolonged or intense mechanical loading.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
IL-1 beta decreases the elastic modulus of human tenocytes
JOURNAL OF APPLIED PHYSIOLOGY, 101(1), 189–195.
author keywords: interleukin-1 beta; cell modulus; tendon; actin; tubulin
MeSH headings : Actin Cytoskeleton / chemistry; Actin Cytoskeleton / drug effects; Actin Cytoskeleton / physiology; Actins / metabolism; Aged; Aged, 80 and over; Biomechanical Phenomena; Cell Shape / drug effects; Cell Shape / physiology; Cell Survival / physiology; Cells, Cultured; Child, Preschool; Elasticity / drug effects; Female; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / physiology; Gene Expression Regulation / physiology; Humans; Interleukin-1 / physiology; Male; Microtubules / chemistry; Microtubules / drug effects; Microtubules / physiology; Tendons / cytology; Tendons / drug effects; Tendons / physiology; Tubulin / metabolism; Weight-Bearing
TL;DR:
Cellular responses to mechanical stimuli are regulated by interactions with the extracellular matrix, which, in turn, are strongly influenced by the degree of cell stiffness (Young's modulus).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018