Michele DeRider

Works (1)

Updated: July 5th, 2023 15:55

2006 article

A Counterintuitive Mg2+-dependent and Modification-assisted Functional Folding of Mitochondrial tRNAs

Jones, C. I., Spencer, A. C., Hsu, J. L., Spremulli, L. L., Martinis, S. A., DeRider, M., & Agris, P. F. (2006, August 1). Journal of Molecular Biology.

By: C. Jones n, A. Spencer*, J. Hsu *, L. Spremulli*, S. Martinis *, M. DeRider n, P. Agris n

author keywords: mitochondrial RNA folding; aminoacylation; tRNA(Met); tRNA(Leu)
MeSH headings : Aminoacylation; Animals; Base Sequence; Cattle; Circular Dichroism; Electrophoretic Mobility Shift Assay; Escherichia coli / chemistry; Magnesium / metabolism; Magnesium / pharmacology; Molecular Sequence Data; Nucleic Acid Conformation / drug effects; Nucleic Acid Denaturation; RNA / chemistry; RNA / genetics; RNA Stability / drug effects; RNA, Mitochondrial; RNA, Transfer / chemistry; RNA, Transfer / genetics; Temperature; Yeasts / chemistry
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Genomics and Phylogenetic Studies
TL;DR: Investigation of functional folding interactions of chemically synthesized and site-specifically modified mitochondrial and cytoplasmic tRNAs finds that Mg2+ is critical for folding of the truncated D-domain of bovine mtRNAMet with the tRNA's T-domain and indicates that conserved modifications assist and stabilize the formation of the functional mtRNA tertiary structure. (via Semantic Scholar)
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Added: August 6, 2018

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