Works (1)

Updated: July 5th, 2023 15:55

2006 journal article

Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice


By: C. Houle n, T. Ton*, N. Clayton*, J. Huff*, H. Hong & R. Sills*

author keywords: p53; H-ras; benzene; ethylene oxide; mammary gland carcinoma; mice; carcinogen
MeSH headings : Animals; Benzene; Carcinogens; Codon; DNA Mutational Analysis; Ethylene Oxide; Exons; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Immunohistochemistry; Mammary Neoplasms, Animal / chemically induced; Mammary Neoplasms, Animal / genetics; Mammary Neoplasms, Animal / metabolism; Mammary Neoplasms, Animal / pathology; Mammary Neoplasms, Experimental / chemically induced; Mammary Neoplasms, Experimental / genetics; Mammary Neoplasms, Experimental / metabolism; Mammary Neoplasms, Experimental / pathology; Mice; Mutation; Polymerase Chain Reaction; Rodent Diseases / chemically induced; Rodent Diseases / genetics; Rodent Diseases / metabolism; Rodent Diseases / pathology; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR: The results demonstrate that p53 and H-ras mutations are relatively common in control and chemically induced mouse mammary carcinomas although both chemicals can alter the mutational spectra and more commonly induce concurrent mutations. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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