Robert C. Sills

Works (2)

Updated: July 5th, 2023 15:55

2010 journal article

H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises

VETERINARY PATHOLOGY, 48(4), 868–874.

By: J. Cullen n, C. Williams*, L. Zadrozny n, J. Otstot*, G. Solomon*, R. Sills*, H. Hong*

author keywords: liver; molecular biology; oncology; primate; zoo; hepatocellular carcinoma
MeSH headings : Animals; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Carcinoma, Hepatocellular / veterinary; Consensus Sequence; Female; Gene Expression Regulation, Neoplastic; Genes, ras / genetics; Lemur; Liver Neoplasms / genetics; Liver Neoplasms / pathology; Liver Neoplasms / veterinary; Lorisidae; Male; Mutation; Primate Diseases / genetics; Primate Diseases / pathology
TL;DR: The authors have determined a consensus sequence for exons 1 and 2 of H-ras from captive lemurs and lorises and evaluated samples of nonneoplastic liver and hepatocellular carcinomas from affected animals for mutations in these exons, and have determined that it is identical to that of human H-ra and differs only slightly from the chimpanzee sequence. (via Semantic Scholar)
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Added: August 6, 2018

2006 journal article

Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice

TOXICOLOGIC PATHOLOGY, 34(6), 752–762.

By: C. Houle n, T. Ton*, N. Clayton*, J. Huff*, H. Hong & R. Sills*

author keywords: p53; H-ras; benzene; ethylene oxide; mammary gland carcinoma; mice; carcinogen
MeSH headings : Animals; Benzene; Carcinogens; Codon; DNA Mutational Analysis; Ethylene Oxide; Exons; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Immunohistochemistry; Mammary Neoplasms, Animal / chemically induced; Mammary Neoplasms, Animal / genetics; Mammary Neoplasms, Animal / metabolism; Mammary Neoplasms, Animal / pathology; Mammary Neoplasms, Experimental / chemically induced; Mammary Neoplasms, Experimental / genetics; Mammary Neoplasms, Experimental / metabolism; Mammary Neoplasms, Experimental / pathology; Mice; Mutation; Polymerase Chain Reaction; Rodent Diseases / chemically induced; Rodent Diseases / genetics; Rodent Diseases / metabolism; Rodent Diseases / pathology; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR: The results demonstrate that p53 and H-ras mutations are relatively common in control and chemically induced mouse mammary carcinomas although both chemicals can alter the mutational spectra and more commonly induce concurrent mutations. (via Semantic Scholar)
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Added: August 6, 2018

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