Works (40)
Updated: April 16th, 2024 05:01
2024 journal article
The Impact of Inorganic Systems and Photoactive Metal Compounds on Cytochrome P450 Enzymes and Metabolism: From Induction to Inhibition
Biomolecules.
www.mdpi.com (publisher PDF)
Source: ORCID
Added: April 8, 2024
2022 journal article
Fine‐Feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity <sup>†
Photochemistry and Photobiology, 98(1), 73–84.
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Coordination Complexes / chemistry; Coordination Complexes / pharmacology; Ligands; Ruthenium / chemistry; Ruthenium / pharmacology; Singlet Oxygen / chemistry
TL;DR:
The results here are consistent with the earlier findings in that seemingly minor structural modifications on the non‐strained ligand can dramatically modulate the normoxic and hypoxic activity of these strained compounds and that these changes appear to exert a greater influence on photocytotoxicity than singlet oxygen sensitization or rates of photosubstitution in cell‐free conditions would suggest.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 28, 2023
2022 journal article
Ru(II) photocages enable precise control over enzyme activity with red light
Nature Communications.
MeSH headings : Cytochrome P-450 CYP1B1 / genetics; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Drug Interactions; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / pharmacology; Humans; Neoplasms; Ruthenium
TL;DR:
The creation of light-triggered CYP1B1 inhibitors as “prodrugs” are described, and achieve >6000-fold improvement in potency upon activation with low-energy (660 nm) light.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 23, 2023
2022 conference paper
Ru-PROTACs are a Promising Tool for the Photocontrol of Protein Degradation
Metals in Medicine, Gordon Research Conference. Presented at the Metals in Medicine, Gordon Research Conference.
Event: Metals in Medicine, Gordon Research Conference
Source: NC State University Libraries
Added: February 3, 2023
2021 journal article
Biological Investigations of Ru(II) Complexes with Diverse β‐Diketone Ligands
European Journal of Inorganic Chemistry, 2021(35), 3611–3621.
author keywords: Antitumor agents; Cytotoxicity; Photophysics; Ruthenium
TL;DR:
It is suggested that κ2-O,O'-ligands can be incorporated into Ru(II)-polypyridyl complexes to create favorable candidates for future drug development.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 29, 2023
2021 journal article
Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes
Current Opinion in Chemical Biology, 61, 191–202.
author keywords: Ligand; Polypyridyl; 1,10-Phenanthroline; Copper; Iron; Ruthenium; Chemotherapy; Natural products
MeSH headings : Chemistry, Bioinorganic; Ligands; Metal Nanoparticles / chemistry; Pyridines / chemistry
TL;DR:
The hypothesis that biological effects are governed by the availability of and affinity for specific metal ions within the experimental model is offered.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 29, 2023
2020 journal article
Avobenzone incorporation in a diverse range of Ru(<scp>ii</scp>) scaffolds produces potent potential antineoplastic agents
Dalton Transactions, 49(35), 12161–12167.
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Coordination Complexes / chemistry; Coordination Complexes / pharmacology; Humans; Ligands; Photochemotherapy; Propiophenones / chemistry; Ruthenium / chemistry; Structure-Activity Relationship
TL;DR:
Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 28, 2023
2020 journal article
Photochemical and Photobiological Properties of Pyridyl-pyrazol(in)e-Based Ruthenium(II) Complexes with Sub-micromolar Cytotoxicity for Phototherapy
ACS Omega, 5(30), 18894–18906.
TL;DR:
Light-mediated activation of “strained” Ru(II) polypyridyl complexes resulted in ligand release and produced a ligand-deficient metal center capable of forming covalent adducts with biomolecules such as DNA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: January 23, 2023
2020 journal article
Strained, Photoejecting Ru(II) Complexes that are Cytotoxic Under Hypoxic Conditions
Photochemistry and Photobiology, 96(2), 327–339.
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Cell Hypoxia; Coordination Complexes / chemistry; Oxygen / metabolism; Ruthenium Compounds / chemistry; Ruthenium Compounds / metabolism; Ruthenium Compounds / pharmacology; Spectrum Analysis / methods
TL;DR:
The structure and nature of the aromatic group had a subtle impact on photochemistry, altering environmental sensitivity, and had a significant impact on cellular cytotoxicity and photobiology.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 28, 2023
2020 journal article
Toward Optimal Ru(II) Photocages: Balancing Photochemistry, Stability, and Biocompatibility Through Fine Tuning of Steric, Electronic, and Physiochemical Features
Inorganic Chemistry, 59(2), 1006–1013.
TL;DR:
Three new scaffolds were designed to improve key properties through modulation of a combination of electronic, steric, and physiochemical features of the most commonly used Ru(II) complex photocages.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 29, 2023
2018 conference paper
Ru(II) CYP1B1 Inhibitor Prodrugs with Enhanced Potency
Metals in Medicine, Gordon Research Conference. Presented at the Gordon Research Conference.
Event: Gordon Research Conference
Source: NC State University Libraries
Added: February 14, 2023
2018 journal article
Ru(ii) complexes with diazine ligands: electronic modulation of the coordinating group is key to the design of “dual action” photoactivated agents
Chemical Communications, 54(88), 12487–12490.
Contributors: * , M. Deshpande*, S. Parkin * & E. Glazer *
TL;DR:
This effect is general, as it is effective with different Ru(ii) structures, and demonstrates that diazine-based drugs are the preferred choice for the development of light-activated dual action Ru(II) agents.
(via Semantic Scholar)
Source: ORCID
Added: January 23, 2023
2018 journal article
Structure-activity relationships of anticancer ruthenium(II) complexes with substituted hydroxyquinolines
European Journal of Medicinal Chemistry, 156, 790–799.
Contributors: * , B. Howerton*, L. Nease*, S. Parkin *, D. Heidary * & E. Glazer *
author keywords: Cytotoxic; Ruthenium; Cancer; Coordination chemistry; Translation
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Coordination Complexes / chemistry; Coordination Complexes / pharmacology; Humans; Hydroxyquinolines / chemistry; Hydroxyquinolines / pharmacology; Ligands; Models, Molecular; Neoplasms / drug therapy; Neoplasms / genetics; Protein Biosynthesis / drug effects; Ruthenium / chemistry; Ruthenium / pharmacology; Structure-Activity Relationship; Transcription, Genetic / drug effects
TL;DR:
The effects were seen at 2-15-fold higher concentrations than those required to observe cytotoxicity, suggesting that prevention of protein synthesis may be a primary, but not the exclusive mechanism for the observed cytotoxic activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 29, 2023
2017 journal article
Back Cover: Photochemical Properties and Structure–Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents (Eur. J. Inorg. Chem. 12/2017)
European Journal of Inorganic Chemistry.
Source: ORCID
Added: January 23, 2023
2017 journal article
Photochemical Properties and Structure–Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents
European Journal of Inorganic Chemistry, 2017(12), 1687–1694.
Contributors: * , D. Heidary *, L. Nease*, S. Parkin * & E. Glazer *
author keywords: Synthesis; Photochemistry; Cytotoxicity; DNA damage; Ruthenium
TL;DR:
The structure-activity relationship was focused on the benzazole core bioisosterism and replacement of coligands in Ru(II) complexes, which were non-toxic in the absence of light, induced cytotoxicity at nanomolar concentrations after light irradiation, and are capable of light-induced DNA damage.
(via Semantic Scholar)
Source: ORCID
Added: January 23, 2023
2016 conference paper
Synthesis, SAR analysis and Mechanistic Studies of New 2-R-Methyl-8-hydroxyquinoline Based Ruthenium(II) Complexes with Promising Antitumor Activity
2nd Annual Postdoctoral Research Symposium. Presented at the 2nd Annual Postdoctoral Research Symposium, Lexington, KY.
Event: 2nd Annual Postdoctoral Research Symposium at Lexington, KY
Source: NC State University Libraries
Added: February 18, 2023
2015 journal article
BIOCHEMICAL INDICATORS OF HEPATOTOXICITY IN BLOOD SERUM OF RATS UNDER THE EFFECT OF NOVEL 4-THIAZOLIDINONE DERIVATIVES AND DOXORUBICIN AND THEIR COMPLEXES WITH POLYETHYLENEGLYCOL-CONTAINING NANOSCALE POLYMERIC CARRIER
Ukrainian Biochemical Journal, 87(2), 122–132. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940029286&partnerID=MN8TOARS
Source: ORCID
Added: January 23, 2023
2015 journal article
Synthesis, Biological activity of thiazolidinones bearing indoline moiety and isatin based hybrids
Mini-Reviews in Organic Chemistry, 12(1), 66–87. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920862003&partnerID=MN8TOARS
Source: ORCID
Added: January 23, 2023
2014 journal article
3D-MoRSE descriptors explained
Journal of Molecular Graphics and Modelling, 54, 194–203.
Contributors: O. Devinyak *, * & R. Lesyk *
author keywords: 3D-MoRSE descriptors; QSAR; Radial basis function; Descriptor interpretation; Structure encoding
MeSH headings : Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship
TL;DR:
This study is intended to lift the veil of mystery, providing a comprehensible way to the interpretation of 3D-MoRSE descriptors in QSAR/QSPR studies.
(via Semantic Scholar)
Source: ORCID
Added: January 23, 2023
2014 journal article
Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds
Bioorganic and Medicinal Chemistry, 22(15), 3815–3823.
Contributors: S. Avdieiev*, L. Gera*, * , R. Hodges *, R. Lesyk *, V. Ribrag *, Y. Vassetzky *, V. Kavsan*
author keywords: Multitargeted complex therapy; Glioblastoma; Mantle cell lymphoma; Bradykinin antagonists; Thiazolidinones
MeSH headings : Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Bradykinin / antagonists & inhibitors; Bradykinin / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Dacarbazine / analogs & derivatives; Dacarbazine / chemistry; Dacarbazine / pharmacology; HEK293 Cells; Humans; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Phosphorylation / drug effects; Proto-Oncogene Proteins c-akt / metabolism; Temozolomide; Thiazolidines / chemical synthesis; Thiazolidines / chemistry; Thiazolidines / pharmacology; Tyrosine / analogs & derivatives; Tyrosine / chemistry; Tyrosine / pharmacology
TL;DR:
A strong synergistic effect after combinatorial treatment by BKM-570 together with TMZ that drastically increased cytotoxic action of this drug in rat and human glioma cells is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 23, 2023
2014 journal article
Computational search for possible mechanisms of 4-thiazolidinones anticancer activity: The power of visualization
Molecular Informatics, 33(3), 216–229.
Contributors: O. Devinyak *, * , B. Zimenkovsky* & R. Lesyk
author keywords: Activity patterns; Anticancer activity; Database mining; 4-Thiazolidinones; Visualization
TL;DR:
The novel protocol of NCI databases mining where inferences are based on the visualization is presented and utilized with the aim to identify putative biological routes of 4‐thiazolidinones anticancer effect, and the obtained results bring medicinal chemistry closer to the understanding of basic nature of 4-thiazol‐2‐ones effect on cancer cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 23, 2023
2014 journal article
Study of antineoplastic action of novel isomeric derivatives of 4-thiazolidinone
Ukrainian Biochemical Journal, 86(6), 96–105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938071889&partnerID=MN8TOARS
Source: ORCID
Added: January 23, 2023
2014 journal article
Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity
European Journal of Medicinal Chemistry, 85, 245–254.
Contributors: * , B. Zimenkovsky*, O. Karpenko*, P. Grellier * & R. Lesyk
author keywords: Synthesis; Pyrazolines; 4-Thiazolidinones; Antitrypanosomal activity
MeSH headings : Animals; Cell Line; Chemistry Techniques, Synthetic; Drug Design; Pyrazoles / chemistry; Rats; Structure-Activity Relationship; Thiazolidines / chemical synthesis; Thiazolidines / chemistry; Thiazolidines / pharmacology; Thiazolidines / toxicity; Trypanocidal Agents / chemical synthesis; Trypanocidal Agents / chemistry; Trypanocidal Agents / pharmacology; Trypanocidal Agents / toxicity; Trypanosoma brucei brucei / drug effects
TL;DR:
It was shown that methyl or aryl substitution at the thiazolidinone N3-position is crucial for trypanocidal activity, and these compounds, as well as 6d and 6e had selectivity index higher than 50, and were more selective than nifurtimox.
(via Semantic Scholar)
Source: ORCID
Added: January 23, 2023
2014 journal article
Virtual screening and its experimental validation reveal novel compounds with promising anticancer activity among 4-thiazolidinone- pyrazoline- and isatin-based conjugates
Austin Journal of Bioorganic & Organic Chemistry, 1(1), 6.
Source: NC State University Libraries
Added: February 18, 2023
2013 journal article
Synthesis and anticancer and antiviral activities of new 2-pyrazoline-substituted 4-thiazolidinones
Journal of Heterocyclic Chemistry, 50(SUPPL.1).
TL;DR:
The screening of antiviral activity for a broad panel of viruses revealed that N-(4-methoxyphenyl)-2-{2-3-phenyl-4,5-dihydropyrazol-1-yl]-acetamide 4a was highly active against Tacaribe TRVL 11 573 virus strain (EC50 = 0.71 μg/mL, selectivity index = 130).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 23, 2023
2013 journal article
Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones
European Journal of Medicinal Chemistry, 66, 228–237.
Contributors: * , B. Zimenkovsky*, O. Vasylenko*, C. Day*, D. Smee*, P. Grellier *, R. Lesyk
author keywords: Synthesis; Pyrazolines; 4-Thiazolidinones; Anticancer activity; Antitrypanosomal activity; Antiviral activity
MeSH headings : Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antiprotozoal Agents / chemical synthesis; Antiprotozoal Agents / chemistry; Antiprotozoal Agents / pharmacology; Antiviral Agents / chemical synthesis; Antiviral Agents / chemistry; Antiviral Agents / pharmacology; Cell Line, Tumor; Chemistry Techniques, Synthetic; Humans; Pyrazoles / chemistry; Structure-Activity Relationship; Thiazolidines / chemical synthesis; Thiazolidines / chemistry; Thiazolidines / pharmacology; Trypanosoma brucei brucei / drug effects; Viruses / drug effects
TL;DR:
The screening of antitrypanosomal and antiviral activities of 5-(3-naphthalen-2-yl-5-aryl-4,5-dihydropyrazol-1-yl)-thiazolidine-2,4-diones was carried out with the promising influence of the mentioned compounds on Trypanosoma brucei, but minimal effect on SARS coronavirus and influenza types A and B viruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 23, 2023
2013 journal article
Synthesis and biological activity of isatines bearing thiazolidinone and pyrazoline moieties
Pharmacia, 60(1), 8–18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888407984&partnerID=MN8TOARS
Source: ORCID
Added: January 23, 2023
2013 journal article
Synthesis of 3S-substituted triazino[5,6-b]indoles and 4-thiazolidinone-triazino[5,6-b]indole hybrids with antitumor activity
Chemistry and Chemical Technology, 7(4), 381–389. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897827225&partnerID=MN8TOARS
Source: ORCID
Added: January 23, 2023
2012 journal article
Study of molecular mechanisms of proapoptotic action of novel heterocyclic 4-thiazolidone derivatives
Biopolymers and Cell, 28(2), 121–128.
Contributors: R. Panchuk *, V. Chumak *, M. Fil *, * , B. Zimenkovsky*, R. Lesyk*, R. Stoika *
TL;DR:
Structural-functional relationships between the presence of specific side groups in novel 4-thiazolidones and the signaling apoptotic pathways induced by these compounds have been established and allow designing new, «hybrid» compounds which can simultaneously induce more than one apoptotic pathway in tumor cells.
(via Semantic Scholar)
Source: ORCID
Added: January 23, 2023
2012 journal article
Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity
Journal of Medicinal Chemistry, 55(20), 8630–8641.
Contributors: * , B. Zimenkovsky*, O. Vasylenko*, A. Gzella * & R. Lesyk*
MeSH headings : Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Isatin / analogs & derivatives; Isatin / chemical synthesis; Isatin / chemistry; Isatin / pharmacology; Pyrazoles / chemical synthesis; Pyrazoles / chemistry; Pyrazoles / pharmacology; Structure-Activity Relationship; Thiazolidines / chemical synthesis; Thiazolidines / chemistry; Thiazolidines / pharmacology
TL;DR:
The most effective anticancer compound 10 was found to be active with mean GI₅₀ and TGI values of 0.071 μM and 0.76 μM, respectively and demonstrated the highest antiproliferative influence on the non-small-cell lung cancer cell line HOP-92.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 23, 2023
2011 journal article
Comparison of dual acting drugs and conventional NSAIDs towards parameters of NO-synthase system and oxidative stress in mucosal membrane of large intestine of rats with experimental ulcerative colitis
Biopolymers and Cell, 27(2), 147–153. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957764684&partnerID=MN8TOARS
Source: ORCID
Added: January 23, 2023
2011 conference paper
Design, synthesis and antitumor activity screening of novel heterocyclic derivatives of 4-thiazolidinones based on the hybrid pharmacophore approach
Bridges in Life Sciences: 6th Annual Scientific Meeting RECOOP HST. Presented at the 6th Annual Scientific Meeting RECOOP HST, Bratislava, Slovak Republic.
Event: 6th Annual Scientific Meeting RECOOP HST at Bratislava, Slovak Republic on April 8-10, 2011
Source: NC State University Libraries
Added: February 18, 2023
2011 journal article
Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates
Archiv Der Pharmazie, 344(8), 514–522.
author keywords: Anticancer activity; Isatines; Pyrazolines; 4-Thiazolidinones
Source: ORCID
Added: January 23, 2023
2011 journal article
Thiazolidinone motif in anticancer drug discovery. Experience of DH LNMU medicinal chemistry scientific group
Biopolymers and Cell, 27(2), 107–117. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957671997&partnerID=MN8TOARS
Contributors: R. Lesyk, B. Zimenkovsky, D. Kaminskyy, A. Kryshchyshyn, D. Havryluk, D. Atamanyuk, I. Subtel'na, D. Khyluk
Source: ORCID
Added: January 23, 2023
2010 journal article
Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety
European Journal of Medicinal Chemistry, 45(11), 5012–5021.
Contributors: * , L. Mosula*, B. Zimenkovsky*, O. Vasylenko*, A. Gzella * & R. Lesyk
author keywords: 4-Thiazolidinones; Benzothiazoles; Knoevenagel reaction; X-ray study; Anticancer activity
MeSH headings : Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Benzothiazoles / chemistry; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Magnetic Resonance Spectroscopy; Models, Molecular; Spectrophotometry, Infrared; Thiazoles / chemical synthesis; Thiazoles / chemistry; Thiazoles / pharmacology
TL;DR:
In vitro anticancer activity of the synthesized compounds was tested by the National Cancer Institute and two of them has revealed the antic cancer activity on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate and breast cancers cell lines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 23, 2023
2010 conference paper
Synthesis and antitumor activity of thiazolidinones with pyrazoline moiety.Streszczenia farmacja polska na tle unii europejskiej
XXI Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Gdansk, Poland. Presented at the XXI Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Gdansk, Poland.
Event: XXI Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Gdansk at Poland on September 12-15, 2010
Source: NC State University Libraries
Added: February 18, 2023
2010 journal article
Synthesis of new 4-azolidinones with 3,5-diaryl-4,5-dihydropyrazole moiety and evaluation of their antitumor activity in vitro
Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia, 23(3), 173–177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860479489&partnerID=MN8TOARS
Source: ORCID
Added: January 23, 2023
2009 journal article
Synthesis and anticancer activity of novel nonfused bicyclic thiazolidinone derivatives
Phosphorus, Sulfur and Silicon and the Related Elements, 184(3), 638–650.
author keywords: Anticancer activity; [2+3]-cyclization; thiazolidinones
TL;DR:
The most efficient antitumor agent was found to be active against leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancer cell lines with mean lgGI50 and lgTGI values of –5.35 and –4.78, respectively.
(via Semantic Scholar)
Source: ORCID
Added: January 23, 2023
2009 journal article
Synthesis and antitumor activity of novel 2-thioxo-4-thiazolidinones with benzothiazole moieties
Farmacia, 57(3), 321–330. http://www.scopus.com/inward/record.url?eid=2-s2.0-69249231104&partnerID=MN8TOARS
Source: ORCID
Added: January 23, 2023
2009 journal article
Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity
European Journal of Medicinal Chemistry, 44(4), 1396–1404.
Contributors: * , B. Zimenkovsky*, O. Vasylenko*, L. Zaprutko *, A. Gzella * & R. Lesyk
author keywords: Thiazolones; Pyrazolines; Knoevenagel reaction; X-ray study; Anticancer activity
MeSH headings : Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Line, Tumor; Cell Proliferation / drug effects; Dose-Response Relationship, Drug; Humans; Neoplasms / drug therapy; Neoplasms / pathology; Pyrazoles / chemistry; Thiazoles / chemical synthesis; Thiazoles / chemistry; Thiazoles / pharmacology
TL;DR:
The most efficient anticancer compound 16 was found to be active with selective influence on colon cancer cell lines, especially on HT 29 (logGI(50)=-6.37) and in vitro anticancer activity of synthesized compounds were tested by the National Cancer Institute.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 23, 2023
Employment
Updated: January 23rd, 2023 13:04
2023 - present
North Carolina State University Raleigh, North Carolina, US
Senior Research Scholar
Department of Chemistry
2019 - 2023
University of Kentucky Lexington, Kentucky, US
Research Assistant Professor
Chemistry
2015 - 2019
University of Kentucky Lexington, KY, US
Postdoctoral Scholar
Chemistry Department
2007 - 2015
Danylo Halytsky Lviv National Medical University Lviv, UA
Assistant Professor
Department of Pharmaceutical, Organic and Bioorganic Chemistry
Education
Updated: December 14th, 2015 10:30
2004 - 2007
Danylo Halytsky Lviv National Medical University Lviv, UA
PhD
Department of Pharmaceutical, Organic and Bioorganic Chemistry
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