2024 review
The Impact of Inorganic Systems and Photoactive Metal Compounds on Cytochrome P450 Enzymes and Metabolism: From Induction to Inhibition
[Review of ]. BIOMOLECULES, 14(4).
2022 journal article
Ru(II) photocages enable precise control over enzyme activity with red light
Nature Communications.
2022 conference paper
Ru-PROTACs are a Promising Tool for the Photocontrol of Protein Degradation
Metals in Medicine, Gordon Research Conference. Presented at the Metals in Medicine, Gordon Research Conference.
Event: Metals in Medicine, Gordon Research Conference
2021 journal article
Biological Investigations of Ru(II) Complexes with Diverse β‐Diketone Ligands
European Journal of Inorganic Chemistry, 2021(35), 3611–3621.
2021 journal article
Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes
Current Opinion in Chemical Biology, 61, 191–202.
2021 journal article
Fine‐Feature Modifications to Strained Ruthenium Complexes Radically Alter Their Hypoxic Anticancer Activity <sup>†
Photochemistry and Photobiology, 98(1), 73–84.
2020 journal article
Avobenzone incorporation in a diverse range of Ru(<scp>ii</scp>) scaffolds produces potent potential antineoplastic agents
Dalton Transactions, 49(35), 12161–12167.
2020 journal article
Photochemical and Photobiological Properties of Pyridyl-pyrazol(in)e-Based Ruthenium(II) Complexes with Sub-micromolar Cytotoxicity for Phototherapy
ACS Omega, 5(30), 18894–18906.
2020 journal article
Toward Optimal Ru(II) Photocages: Balancing Photochemistry, Stability, and Biocompatibility Through Fine Tuning of Steric, Electronic, and Physiochemical Features
Inorganic Chemistry, 59(2), 1006–1013.
2019 journal article
Strained, Photoejecting Ru(II) Complexes that are Cytotoxic Under Hypoxic Conditions
Photochemistry and Photobiology, 96(2), 327–339.
2018 conference paper
Ru(II) CYP1B1 Inhibitor Prodrugs with Enhanced Potency
Metals in Medicine, Gordon Research Conference. Presented at the Gordon Research Conference.
Event: Gordon Research Conference
2018 journal article
Ru(ii) complexes with diazine ligands: electronic modulation of the coordinating group is key to the design of “dual action” photoactivated agents
Chemical Communications, 54(88), 12487–12490.
Contributors: , M. Deshpande *, S. Parkin * & E. Glazer * *
2018 journal article
Structure-activity relationships of anticancer ruthenium(II) complexes with substituted hydroxyquinolines
European Journal of Medicinal Chemistry, 156, 790–799.
Contributors: , B. Howerton*, L. Nease*, S. Parkin *, D. Heidary * & E. Glazer * *
2017 journal article
Back Cover: Photochemical Properties and Structure–Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents (Eur. J. Inorg. Chem. 12/2017)
European Journal of Inorganic Chemistry.
2017 journal article
Photochemical Properties and Structure–Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents
European Journal of Inorganic Chemistry, 2017(12), 1687–1694.
Contributors: , D. Heidary *, L. Nease*, S. Parkin * & E. Glazer * *
2016 conference paper
Synthesis, SAR analysis and Mechanistic Studies of New 2-R-Methyl-8-hydroxyquinoline Based Ruthenium(II) Complexes with Promising Antitumor Activity
2nd Annual Postdoctoral Research Symposium. Presented at the 2nd Annual Postdoctoral Research Symposium, Lexington, KY.
Event: 2nd Annual Postdoctoral Research Symposium at Lexington, KY
2015 journal article
BIOCHEMICAL INDICATORS OF HEPATOTOXICITY IN BLOOD SERUM OF RATS UNDER THE EFFECT OF NOVEL 4-THIAZOLIDINONE DERIVATIVES AND DOXORUBICIN AND THEIR COMPLEXES WITH POLYETHYLENEGLYCOL-CONTAINING NANOSCALE POLYMERIC CARRIER
Ukrainian Biochemical Journal, 87(2), 122–132. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940029286&partnerID=MN8TOARS
2015 journal article
Synthesis, Biological activity of thiazolidinones bearing indoline moiety and isatin based hybrids
Mini-Reviews in Organic Chemistry, 12(1), 66–87. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920862003&partnerID=MN8TOARS
2014 journal article
3D-MoRSE descriptors explained
Journal of Molecular Graphics and Modelling, 54, 194–203.
Contributors: O. Devinyak *, * & R. Lesyk *
2014 journal article
Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds
Bioorganic and Medicinal Chemistry, 22(15), 3815–3823.
Contributors: S. Avdieiev *, L. Gera*, * , R. Hodges *, R. Lesyk *, V. Ribrag *, Y. Vassetzky *, V. Kavsan*
2014 journal article
Computational search for possible mechanisms of 4-thiazolidinones anticancer activity: The power of visualization
Molecular Informatics, 33(3), 216–229.
Contributors: O. Devinyak *, * , B. Zimenkovsky * & R. Lesyk *
2014 journal article
Study of antineoplastic action of novel isomeric derivatives of 4-thiazolidinone
Ukrainian Biochemical Journal, 86(6), 96–105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938071889&partnerID=MN8TOARS
2014 journal article
Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity
European Journal of Medicinal Chemistry, 85, 245–254.
Contributors: , B. Zimenkovsky *, O. Karpenko*, P. Grellier * & R. Lesyk * *
2014 journal article
Virtual screening and its experimental validation reveal novel compounds with promising anticancer activity among 4-thiazolidinone- pyrazoline- and isatin-based conjugates
Austin Journal of Bioorganic & Organic Chemistry, 1(1), 6.
2013 journal article
Synthesis and anticancer and antiviral activities of new 2-pyrazoline-substituted 4-thiazolidinones
Journal of Heterocyclic Chemistry, 50(SUPPL.1).
Contributors: , B. Zimenkovsky *, O. Vasylenko * & R. Lesyk * *
2013 journal article
Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones
European Journal of Medicinal Chemistry, 66, 228–237.
Contributors: , B. Zimenkovsky *, O. Vasylenko *, C. Day*, D. Smee *, P. Grellier *, R. Lesyk * *
2013 journal article
Synthesis and biological activity of isatines bearing thiazolidinone and pyrazoline moieties
Pharmacia, 60(1), 8–18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888407984&partnerID=MN8TOARS
2013 journal article
Synthesis of 3S-substituted triazino[5,6-b]indoles and 4-thiazolidinone-triazino[5,6-b]indole hybrids with antitumor activity
Chemistry and Chemical Technology, 7(4), 381–389. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897827225&partnerID=MN8TOARS
2012 journal article
Study of molecular mechanisms of proapoptotic action of novel heterocyclic 4-thiazolidone derivatives
Biopolymers and Cell, 28(2), 121–128.
Contributors: R. Panchuk *, V. Chumak *, M. Fil *, * , B. Zimenkovsky *, R. Lesyk *, R. Stoika *
2012 journal article
Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity
Journal of Medicinal Chemistry, 55(20), 8630–8641.
Contributors: , B. Zimenkovsky *, O. Vasylenko *, A. Gzella * & R. Lesyk * *
2011 journal article
Comparison of dual acting drugs and conventional NSAIDs towards parameters of NO-synthase system and oxidative stress in mucosal membrane of large intestine of rats with experimental ulcerative colitis
Biopolymers and Cell, 27(2), 147–153. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957764684&partnerID=MN8TOARS
2011 conference paper
Design, synthesis and antitumor activity screening of novel heterocyclic derivatives of 4-thiazolidinones based on the hybrid pharmacophore approach
Bridges in Life Sciences: 6th Annual Scientific Meeting RECOOP HST. Presented at the 6th Annual Scientific Meeting RECOOP HST, Bratislava, Slovak Republic.
Event: 6th Annual Scientific Meeting RECOOP HST at Bratislava, Slovak Republic on April 8-10, 2011
2011 journal article
Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates
Archiv Der Pharmazie, 344(8), 514–522.
2011 journal article
Thiazolidinone motif in anticancer drug discovery. Experience of DH LNMU medicinal chemistry scientific group
Biopolymers and Cell, 27(2), 107–117. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957671997&partnerID=MN8TOARS
Contributors: R. Lesyk, B. Zimenkovsky, D. Kaminskyy, A. Kryshchyshyn, D. Havryluk, D. Atamanyuk, I. Subtel'na, D. Khyluk
2010 journal article
Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety
European Journal of Medicinal Chemistry, 45(11), 5012–5021.
2010 conference paper
Synthesis and antitumor activity of thiazolidinones with pyrazoline moiety.Streszczenia farmacja polska na tle unii europejskiej
XXI Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Gdansk, Poland. Presented at the XXI Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Gdansk, Poland.
Event: XXI Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego Gdansk at Poland on September 12-15, 2010
2010 journal article
Synthesis of new 4-azolidinones with 3,5-diaryl-4,5-dihydropyrazole moiety and evaluation of their antitumor activity in vitro
Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia, 23(3), 173–177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860479489&partnerID=MN8TOARS
2009 journal article
Synthesis and anticancer activity of novel nonfused bicyclic thiazolidinone derivatives
Phosphorus, Sulfur and Silicon and the Related Elements, 184(3), 638–650.
Contributors: , B. Zimenkovsky * & R. Lesyk * *
2009 journal article
Synthesis and antitumor activity of novel 2-thioxo-4-thiazolidinones with benzothiazole moieties
Farmacia, 57(3), 321–330. http://www.scopus.com/inward/record.url?eid=2-s2.0-69249231104&partnerID=MN8TOARS
2008 journal article
Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity
European Journal of Medicinal Chemistry, 44(4), 1396–1404.
Contributors: , B. Zimenkovsky *, O. Vasylenko *, L. Zaprutko *, A. Gzella * & R. Lesyk * *
Updated: January 23rd, 2023 13:04
2023 - present
2019 - 2023
2015 - 2019
2007 - 2015
Updated: December 14th, 2015 10:30
2004 - 2007
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