Gabriela Schroder
Biochemistry
Protein crystallography, Neutron diffraction, Metallo-enzymes, Enzymatic mechanisms, Cytochrome P450, Lytic Polysaccharide Monooxygenase, Unspecific Peroxygenases
Works (4)
Updated: July 16th, 2023 21:15
2022 article
Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase
Schroder, G. C., William B. O'Dell, Webb, S. P., Agarwal, P. K., & Meilleur, F. (2022, November 2). CHEMICAL SCIENCE, Vol. 11.
TL;DR:
It is established that the conserved second-shell His161 in MtPMO3* displays conformational flexibility in solution and that this flexibility is also observed, though to a lesser extent, in His157 of NcLPMO9D.
(via Semantic Scholar)
open access via pubs.rsc.org (publisher PDF)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 3, 2022
2021 journal article
Metalloprotein catalysis: structural and mechanistic insights into oxidoreductases from neutron protein crystallography
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 77(10), 1251–1269.
author keywords: neutron protein crystallography; X-ray diffraction; metalloproteins; enzymatic mechanisms; protonation; radiation damage
MeSH headings : Animals; Catalysis; Crystallography, X-Ray / methods; Humans; Metalloproteins / chemistry; Models, Molecular; Neutron Diffraction / methods; Neutrons; Oxidoreductases / chemistry
TL;DR:
Neutron protein crystallography provides insight into the structure and reaction mechanism of transition-state metal oxidoreductases without resulting in radiation-damage-induced artefacts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
13. Climate Action
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 28, 2021
2021 journal article
Preliminary results of neutron and X-ray diffraction data collection on a lytic polysaccharide monooxygenase under reduced and acidic conditions
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 77(4), 128–133.
author keywords: lytic polysaccharide monooxygenases; Neurospora crassa; neutron protein crystallography; reduction; protonation; enzymatic mechanism.
MeSH headings : Data Collection / methods; Hydrogen-Ion Concentration; Mixed Function Oxygenases / analysis; Mixed Function Oxygenases / chemistry; Neurospora crassa / chemistry; Neutron Diffraction / methods; Polysaccharides / analysis; Polysaccharides / chemistry; Protein Structure, Secondary; X-Ray Diffraction / methods
TL;DR:
To characterize the reaction-mechanism intermediates of LPMO9D from Neurospora crassa, a cryo-neutron diffraction data set was collected from an ascorbate-reduced crystal to probe the protonation states of ionizable groups involved in catalysis under acidic conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 1, 2021
2018 journal article
IMAGINE: Neutrons reveal enzyme chemistry
Acta Crystallographica Section D: Structural Biology, 74, 778–786.
Contributors: n , W. O’Dell n, D. Myles *, A. Kovalevsky * & F. Meilleur n
author keywords: neutron crystallography; enzyme mechanisms; deuterons; protons; hydrogen; IMAGINE; neutron diffraction
MeSH headings : Crystallography; Deuterium; Enzymes / chemistry; Hydrogen; Neutron Diffraction / instrumentation; Neutron Diffraction / methods
TL;DR:
This review gives an overview of the IMAGINE beamline at the HFIR, presents examples of the scientific questions being addressed at this beamline, and highlights important findings in enzyme chemistry that have been made using the neutron diffraction capabilities offered by IMAGine.
(via Semantic Scholar)
Source: ORCID
Added: May 25, 2021
Employment
Updated: September 8th, 2022 14:23
2022 - 2022
University of the Free State Bloemfontein, Free State, ZA
Postdoctoral Associate
Department of Molecular and Structural Biochemistry
Education
Updated: September 8th, 2022 14:13
2015 - 2021
NC State University Raleigh, NC, US
PhD
Molecular and Structural Biochemsitry
2014 - 2014
University of the Free State Bloemfontein, Free State, ZA
BSc Honours
Microbial, Biochemical and Food Biotechnology
2010 - 2013
University of the Free State Bloemfontein, Free State, ZA
Bachelor of Science
Biochemistry and Chemistry
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