Gabriela Schroder

Biochemistry

Protein crystallography, Neutron diffraction, Metallo-enzymes, Enzymatic mechanisms, Cytochrome P450, Lytic Polysaccharide Monooxygenase, Unspecific Peroxygenases

Works (4)

Updated: July 16th, 2023 21:15

2022 article

Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase

Schröder, G. C., O'Dell, W. B., Webb, S. P., Agarwal, P. K., & Meilleur, F. (2022, January 1). Chemical Science, Vol. 11.

By: G. Schröder n , W. O'Dell  n, S. Webb *, P. Agarwal * & F. Meilleur n 

Contributors: G. Schröder n , . W.B. O'Dell  n, S. Webb *, P. Agarwal * & F. Meilleur n 

topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Enzyme Structure and Function; Enzyme-mediated dye degradation; Microbial bioremediation and biosurfactants; Microbial metabolism and enzyme function; Microbial Metabolic Engineering and Bioproduction
TL;DR: It is established that the conserved second-shell His161 in MtPMO3* displays conformational flexibility in solution and that this flexibility is also observed, though to a lesser extent, in His157 of NcLPMO9D. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 3, 2022

2021 article

Metalloprotein catalysis: structural and mechanistic insights into oxidoreductases from neutron protein crystallography

Schröder, G. C., & Meilleur, F. (2021, September 27). Acta Crystallographica Section D Structural Biology, Vol. 77, pp. 1251–1269.

By: G. Schröder n  & F. Meilleur n 

Contributors: G. Schröder n  & F. Meilleur n 

author keywords: neutron protein crystallography; X-ray diffraction; metalloproteins; enzymatic mechanisms; protonation; radiation damage
MeSH headings : Animals; Catalysis; Crystallography, X-Ray / methods; Humans; Metalloproteins / chemistry; Models, Molecular; Neutron Diffraction / methods; Neutrons; Oxidoreductases / chemistry
topics (OpenAlex): Enzyme Structure and Function; Mass Spectrometry Techniques and Applications; X-ray Spectroscopy and Fluorescence Analysis
TL;DR: Neutron protein crystallography provides insight into the structure and reaction mechanism of transition-state metal oxidoreductases without resulting in radiation-damage-induced artefacts. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 28, 2021

2021 article

Preliminary results of neutron and X-ray diffraction data collection on a lytic polysaccharide monooxygenase under reduced and acidic conditions

Schröder, G. C., O'Dell, W. B., Swartz, P. D., & Meilleur, F. (2021, March 31). Acta Crystallographica Section F Structural Biology Communications, Vol. 77, pp. 128–133.

By: G. Schröder n , W. O'Dell  n, P. Swartz n & F. Meilleur n 

Contributors: G. Schro der n , W. O Dell  n, P. Swartz n & F. Meilleur n 

author keywords: lytic polysaccharide monooxygenases; Neurospora crassa; neutron protein crystallography; reduction; protonation; enzymatic mechanism.
MeSH headings : Data Collection / methods; Hydrogen-Ion Concentration; Mixed Function Oxygenases / analysis; Mixed Function Oxygenases / chemistry; Neurospora crassa / chemistry; Neutron Diffraction / methods; Polysaccharides / analysis; Polysaccharides / chemistry; Protein Structure, Secondary; X-Ray Diffraction / methods
topics (OpenAlex): Enzyme Structure and Function; Biofuel production and bioconversion; Advanced Cellulose Research Studies
TL;DR: To characterize the reaction-mechanism intermediates of LPMO9D from Neurospora crassa, a cryo-neutron diffraction data set was collected from an ascorbate-reduced crystal to probe the protonation states of ionizable groups involved in catalysis under acidic conditions. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 1, 2021

2018 article

IMAGINE: neutrons reveal enzyme chemistry

Schröder, G. C., O'Dell, W. B., Myles, D. A. A., Kovalevsky, A., & Meilleur, F. (2018, July 17). Acta Crystallographica Section D Structural Biology, Vol. 74, pp. 778–786.

By: G. Schröder n , W. O'Dell  n, D. Myles *, A. Kovalevsky * & F. Meilleur n 

Contributors: G. Schröder n , W. O’Dell  n, D. Myles *, A. Kovalevsky * & F. Meilleur n 

author keywords: neutron crystallography; enzyme mechanisms; deuterons; protons; hydrogen; IMAGINE; neutron diffraction
MeSH headings : Crystallography; Deuterium; Enzymes / chemistry; Hydrogen; Neutron Diffraction / instrumentation; Neutron Diffraction / methods
topics (OpenAlex): Nuclear Physics and Applications; Enzyme Structure and Function; Mass Spectrometry Techniques and Applications
TL;DR: This review gives an overview of the IMAGINE beamline at the HFIR, presents examples of the scientific questions being addressed at this beamline, and highlights important findings in enzyme chemistry that have been made using the neutron diffraction capabilities offered by IMAGine. (via Semantic Scholar)
Source: ORCID
Added: May 25, 2021

Employment

Updated: September 8th, 2022 14:23

2022 - 2022

University of the Free State Bloemfontein, Free State, ZA
Postdoctoral Associate Department of Molecular and Structural Biochemistry

Education

Updated: September 8th, 2022 14:13

2015 - 2021

NC State University Raleigh, NC, US
PhD Molecular and Structural Biochemsitry

2014 - 2014

University of the Free State Bloemfontein, Free State, ZA
BSc Honours Microbial, Biochemical and Food Biotechnology

2010 - 2013

University of the Free State Bloemfontein, Free State, ZA
Bachelor of Science Biochemistry and Chemistry

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