Works (1)
Updated: July 5th, 2023 15:54
2007 journal article
Crystal structure of E47 neuroD1/Beta2 bHLH domain DNA complex: Heterodimer selectivity and DNA recognition
BIOCHEMISTRY, 47(1), 218–229.
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Basic Helix-Loop-Helix Transcription Factors / chemistry; Basic Helix-Loop-Helix Transcription Factors / metabolism; Binding Sites; Crystallography, X-Ray; DNA / chemistry; DNA / genetics; DNA / metabolism; Dimerization; Humans; Mice; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins / chemistry; Nerve Tissue Proteins / metabolism; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; TCF Transcription Factors / chemistry; TCF Transcription Factors / metabolism; Transcription Factor 7-Like 1 Protein
TL;DR:
The crystal structure of the E47-NeuroD1-bHLH dimer in complex with the insulin promoter E-box sequence is determined and it is proposed that concerted domain motions allow E47 to form specific base contacts in solution.
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Added: August 6, 2018
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