Joey Crapster

College of Sciences

Works (2)

Updated: July 6th, 2023 21:18

2023 article

Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction

Huayta, J., Crapster, J. P., & San-Miguel, A. (2023, February 20). Communications Biology, Vol. 6.

By: J. Huayta  n, J. Crapster n & A. San-Miguel n 

MeSH headings : Animals; Caenorhabditis elegans / genetics; Longevity / genetics; Caenorhabditis elegans Proteins / metabolism; Signal Transduction; Insulin / metabolism; Forkhead Transcription Factors / metabolism
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Circadian rhythm and melatonin; Spaceflight effects on biology
TL;DR: The results indicate that DR regimes induce strong endogenous DAF-16 activity, although Daf-16 is less responsive in aged individuals, and analysis of tissue-specific expression aided by a machine learning tissue classifier reveals that, under DR, the largest contribution to D AF-16 nuclear intensity originates from the intestine and neurons. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 27, 2023

2022 article

Identifying C. elegans lifespan mutants by screening for early-onset protein aggregation

Midkiff, D. F., Huayta, J., Lichty, J. D., Crapster, J. P., & San-Miguel, A. (2022, October 28). IScience, Vol. 25, p. 105460.

By: D. Midkiff n, J. Huayta  n, J. Lichty n, J. Crapster n & A. San-Miguel n 

topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms
TL;DR: It is demonstrated that lifespan mutants can be identified by screening for accelerated protein aggregation through quantitative analysis of fluorescently-labeled aggregates in populations that do not require conditional sterilization or manual separation of parental and progeny populations. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 3, 2023

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