Works (3)

Updated: July 5th, 2023 15:53

2014 journal article

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

Journal of Cell Biology, 204(4), 607–623.

By: S. Morioka, P. Broglie, E. Omori, Y. Ikeda, G. Takaesu, K. Matsumoto, J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Transforming Growth Factor beta-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway


MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Line, Transformed; Dermis / cytology; Fibroblasts / cytology; Fibroblasts / enzymology; Gene Deletion; JNK Mitogen-Activated Protein Kinases / metabolism; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System / drug effects; MAP Kinase Signaling System / physiology; Mice; NF-kappa B / metabolism; Phosphoprotein Phosphatases / metabolism; Phosphorylation / physiology; Tumor Necrosis Factor-alpha / metabolism; Tumor Necrosis Factor-alpha / pharmacology; Ubiquitin / metabolism; Ubiquitination / physiology
Source: Web Of Science
Added: August 6, 2018

2008 journal article

TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappa B


By: T. Prickett*, J. Ninomiya-Tsuji n, P. Broglie n, T. Muratore-Schroeder*, J. Shabanowitz*, D. Hunt*, D. Brautigan*

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Motifs / genetics; Amino Acid Substitution; Humans; I-kappa B Kinase / genetics; I-kappa B Kinase / metabolism; Interleukin-1beta / metabolism; MAP Kinase Kinase 3 / genetics; MAP Kinase Kinase 3 / metabolism; MAP Kinase Kinase 6 / genetics; MAP Kinase Kinase 6 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mutation, Missense; NF-kappa B / genetics; NF-kappa B / metabolism; Phosphorylation; Protein Binding / genetics; Protein Structure, Tertiary / genetics; Signal Transduction / physiology; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Ubiquitin / genetics; Ubiquitin / metabolism; p38 Mitogen-Activated Protein Kinases / genetics; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: The results show that TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK 1-TAB1, which activates IKK signaling to NF-κB. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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