Peter M. Broglie

Works (3)

Updated: July 5th, 2023 15:53

2014 journal article

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

Journal of Cell Biology, 204(4), 607–623.

By: S. Morioka, P. Broglie, E. Omori, Y. Ikeda, G. Takaesu, K. Matsumoto, J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Transforming Growth Factor beta-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(4), 2333–2339.

By: P. Broglie n, K. Matsumoto *, S. Akira *, D. Brautigan * & J. Ninomiya-Tsuji n 

Contributors: P. Broglie n, K. Matsumoto *, S. Akira *, D. Brautigan * & J. Ninomiya-Tsuji n 

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Line, Transformed; Dermis / cytology; Fibroblasts / cytology; Fibroblasts / enzymology; Gene Deletion; JNK Mitogen-Activated Protein Kinases / metabolism; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System / drug effects; MAP Kinase Signaling System / physiology; Mice; NF-kappa B / metabolism; Phosphoprotein Phosphatases / metabolism; Phosphorylation / physiology; Tumor Necrosis Factor-alpha / metabolism; Tumor Necrosis Factor-alpha / pharmacology; Ubiquitin / metabolism; Ubiquitination / physiology
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappa B

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(28), 19245–19254.

By: T. Prickett *, J. Ninomiya-Tsuji n , P. Broglie n, T. Muratore-Schroeder*, J. Shabanowitz *, D. Hunt *, D. Brautigan *

Contributors: T. Prickett *, J. Ninomiya-Tsuji n , P. Broglie n, T. Muratore-Schroeder*, J. Shabanowitz *, D. Hunt *, D. Brautigan *

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Motifs / genetics; Amino Acid Substitution; Humans; I-kappa B Kinase / genetics; I-kappa B Kinase / metabolism; Interleukin-1beta / metabolism; MAP Kinase Kinase 3 / genetics; MAP Kinase Kinase 3 / metabolism; MAP Kinase Kinase 6 / genetics; MAP Kinase Kinase 6 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mutation, Missense; NF-kappa B / genetics; NF-kappa B / metabolism; Phosphorylation; Protein Binding / genetics; Protein Structure, Tertiary / genetics; Signal Transduction / physiology; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Ubiquitin / genetics; Ubiquitin / metabolism; p38 Mitogen-Activated Protein Kinases / genetics; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: The results show that TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK 1-TAB1, which activates IKK signaling to NF-κB. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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