Stefani Sykes

Works (1)

Updated: April 5th, 2024 08:31

2014 journal article

Blocking Ligand Occupancy of the alpha V beta 3 Integrin Inhibits the Development of Nephropathy in Diabetic Pigs

ENDOCRINOLOGY, 155(12), 4665–4675.

By: L. Maile*, W. Busby*, K. Gollahon*, W. Flowers n , N. Garbacik n, S. Garbacik n, K. Stewart n, T. Nichols * ...

MeSH headings : Animals; Antibodies, Monoclonal; Diabetic Nephropathies / etiology; Diabetic Nephropathies / metabolism; Diabetic Nephropathies / pathology; Glomerular Basement Membrane / pathology; Integrin alphaVbeta3 / antagonists & inhibitors; Integrin alphaVbeta3 / metabolism; Male; Mice, Inbred BALB C; Podocytes / pathology; Proteinuria / etiology; Swine
TL;DR: Administration of an antibody that inhibits activation of the β3-subunit of αVβ3 that is induced by hyperglycemia attenuates proteinuria and early histologic changes of diabetic nephropathy, suggesting that it may have utility in preventing the progression of this disease complication. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2025) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.