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Works (1)
Updated: April 5th, 2024 08:31
2014 journal article
Blocking Ligand Occupancy of the alpha V beta 3 Integrin Inhibits the Development of Nephropathy in Diabetic Pigs
ENDOCRINOLOGY, 155(12), 4665–4675.
MeSH headings : Animals; Antibodies, Monoclonal; Diabetic Nephropathies / etiology; Diabetic Nephropathies / metabolism; Diabetic Nephropathies / pathology; Glomerular Basement Membrane / pathology; Integrin alphaVbeta3 / antagonists & inhibitors; Integrin alphaVbeta3 / metabolism; Male; Mice, Inbred BALB C; Podocytes / pathology; Proteinuria / etiology; Swine
TL;DR:
Administration of an antibody that inhibits activation of the β3-subunit of αVβ3 that is induced by hyperglycemia attenuates proteinuria and early histologic changes of diabetic nephropathy, suggesting that it may have utility in preventing the progression of this disease complication.
(via Semantic Scholar)
open access via academic.oup.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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