Xun Lu

Works (1)

Updated: July 5th, 2023 15:44

2012 article

A Novel DNA Binding Mechanism for maf Basic Region-Leucine Zipper Factors Inferred from a MafA–DNA Complex Structure and Binding Specificities

Lu, X., Guanga, G. P., Wan, C., & Rose, R. B. (2012, November 13). Biochemistry, Vol. 51, pp. 9706–9717.

By: X. Lu n, G. Guanga, C. Wan & R. Rose n 

MeSH headings : Amino Acid Sequence; Base Sequence; Crystallography, X-Ray; DNA / metabolism; DNA Primers; Electrophoretic Mobility Shift Assay; Leucine Zippers; Maf Transcription Factors, Large / chemistry; Maf Transcription Factors, Large / metabolism; Molecular Sequence Data; Protein Binding; Protein Conformation; Sequence Homology, Amino Acid
topics (OpenAlex): Pancreatic function and diabetes; Metabolism, Diabetes, and Cancer; Endoplasmic Reticulum Stress and Disease
TL;DR: Results suggest a novel multistep DNA binding process involving a conformational change from contacting the core-TGA to contacting the flanking-TGC bases, which is critical for insulin gene expression in pancreatic β-cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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