2023 article
Absorption rate governs cell transduction in dry macroporous scaffolds
VanBlunk, M., Srikanth, V., Pandit, S. S., Kuznetsov, A. V., & Brudno, Y. (2023, January 26). BIOMATERIALS SCIENCE.
MeSH headings : Tissue Scaffolds; Biocompatible Materials; Cell Differentiation; Porosity; Tissue Engineering / methods
TL;DR:
The rate of liquid flow through the scaffolds, rather than pore size or stiffness, serves as a central regulator for efficient Drydux transduction, which provides a fast and inexpensive method for transducing cells for cellular therapy, including for the production of CAR T cells.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 13, 2023
Dry, macroporous scaffolds efficiently transduce T cells, but the mechanism for this transduction has not been studied previously. We report that liquid volume and resultant differences in liquid absorption rates governs cell transduction efficiency.