Sharda Shivprasad Pandit

Works (6)

Updated: September 4th, 2024 05:01

2024 journal article

A biomaterial platform for T cell-specific gene delivery

ACTA BIOMATERIALIA, 177, 157–164.

By: S. Pandit n, B. Smith *, M. Birnbaum * & Y. Brudno n 

author keywords: CAR T cell therapy; Pseudotyped lentivirus; Targeting; T cell activation; Transduction; Alginate; Macroporous scaffolds; T cell engineering; Gene delivery
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Sources: Web Of Science, NC State University Libraries
Added: May 28, 2024

2024 journal article

Implantable CAR T cell factories enhance solid tumor treatment

BIOMATERIALS, 308.

By: S. Pandit n, P. Agarwalla n, F. Song *, A. Jansson*, G. Dotti* & Y. Brudno n 

author keywords: Biomaterials; CAR T cell; immunotherapy; Cell therapy; implant; porous matrix
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Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2023 article

Absorption rate governs cell transduction in dry macroporous scaffolds

VanBlunk, M., Srikanth, V., Pandit, S. S., Kuznetsov, A. V., & Brudno, Y. (2023, January 26). BIOMATERIALS SCIENCE, Vol. 1.

By: M. VanBlunk n, V. Srikanth n, S. Pandit n, A. Kuznetsov n & Y. Brudno n 

MeSH headings : Tissue Scaffolds; Biocompatible Materials; Cell Differentiation; Porosity; Tissue Engineering / methods
TL;DR: The rate of liquid flow through the scaffolds, rather than pore size or stiffness, serves as a central regulator for efficient Drydux transduction, which provides a fast and inexpensive method for transducing cells for cellular therapy, including for the production of CAR T cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023

2022 journal article

Fabrication and Use of Dry Macroporous Alginate Scaffolds for Viral Transduction of T Cells

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 9(187).

By: M. VanBlunk n, P. Agarwalla n, S. Pandit n & Y. Brudno n 

MeSH headings : Alginates; Calcium; Immunotherapy, Adoptive; Receptors, Chimeric Antigen; T-Lymphocytes; Tissue Engineering; Tissue Scaffolds
TL;DR: Dry macroporous alginate scaffolds serve as a cheaper and more convenient alternative to the conventional transduction method for CAR-T cells and are comparable to the transduction efficiency of spinoculation on retronectin-coated plates. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 30, 2023

2022 journal article

Tissue-reactive drugs enable materials-free local depots

JOURNAL OF CONTROLLED RELEASE, 343, 142–151.

By: S. Pandit n, S. Palvai n, N. Massaro n, J. Pierce n  & Y. Brudno n 

author keywords: Sustained release; Materials-free delivery; Paclitaxel; Pancreatic cancer; Extracellular matrix; N-hydroxysuccinimide ester
MeSH headings : Animals; Cell Line, Tumor; Drug Delivery Systems; Drug Liberation; Hydrogels; Mice; Paclitaxel; Pancreatic Neoplasms / drug therapy
TL;DR: It is demonstrated that locally injected TRAPs create dispersed, stable intratumoral depots deep within mouse and human pancreatic tumor tissues, and had better solubility than free paclitaxel and enabled sustained in vitro and in vivo drug release. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2021 journal article

On-Demand Drug Release from Click-Refillable Drug Depots

MOLECULAR PHARMACEUTICS, 18(10), 3920–3925.

By: S. Palvai n, C. Moody n, S. Pandit n & Y. Brudno n 

author keywords: drug delivery; bioorthogonal; stimuli-responsive; photocleavage; click chemistry
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Cell Line, Tumor; Click Chemistry / methods; Delayed-Action Preparations; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Delivery Systems / methods; Drug Liberation; Fluorescent Dyes; Humans; Mice
TL;DR: An on- demand drug delivery paradigm that combines bioorthogonal click chemistry to locally enrich protodrugs at a prelabeled site and light-triggered drug release at the target tissue is reported, establishing a novel method for in vivo targeting and on-demand delivery of cytotoxic drugs at target tissues. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021

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