Peter C. Mann

Works (4)

Updated: July 5th, 2023 16:02

2007 article

Acute Adverse Effects of the Indenopyridine CDB‐4022 on the Ultrastructure of Sertoli Cells, Spermatocytes, and Spermatids in Rat Testes: Comparison to the Known Sertoli Cell Toxicant Di‐n‐pentylphthalate (DPP)

Hild, S. A., Reel, J. R., Dykstra, M. J., Mann, P. C., & Marshall, G. R. (2007, June 22). Journal of Andrology.

By: S. Hild*, J. Reel*, M. Dykstra n, P. Mann* & G. Marshall*

author keywords: antifertility; morphology; ultrastructure; seminiferous; epithelium; germ cells
MeSH headings : Animals; Indenes / toxicity; Male; Phthalic Acids / toxicity; Piperidines / toxicity; Rats; Rats, Sprague-Dawley; Sertoli Cells / drug effects; Sertoli Cells / pathology; Sertoli Cells / ultrastructure; Spermatids / drug effects; Spermatids / pathology; Spermatids / ultrastructure; Spermatocytes / drug effects; Spermatocytes / pathology; Spermatocytes / ultrastructure; Testis / drug effects; Testis / pathology
topics (OpenAlex): Sperm and Testicular Function; Paraquat toxicity studies and treatments; Drug Transport and Resistance Mechanisms
TL;DR: The antispermatogenic activity of CDB-4022 appears to be a consequence of direct effects on Sertoli and germ cells. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 article

Suggested Standard Operating Procedures (SOPs) for the Preparation of Electron Microscopy Samples for Toxicology/Pathology Studies in a GLP Environment

Dykstra, M. J., Mann, P. C., Elwell, M. R., & Ching, S. V. (2002, October 1). Toxicologic Pathology.

By: M. Dykstra n, P. Mann*, M. Elwell* & S. Ching*

author keywords: sample preparation; TEM; SEM; SOPs
MeSH headings : Animals; Drug Evaluation, Preclinical / standards; Facility Regulation and Control / legislation & jurisprudence; Facility Regulation and Control / standards; Health Policy; Laboratories / legislation & jurisprudence; Laboratories / standards; Microscopy, Electron, Scanning / standards; Quality Assurance, Health Care; Rats; Specimen Handling / standards; Toxicity Tests / standards; United States
topics (OpenAlex): Cell Image Analysis Techniques; Animal testing and alternatives; Genetics, Bioinformatics, and Biomedical Research
TL;DR: A set of Standard Operating Procedures for preparing samples for electron microscopic evaluation that allow storage of samples in the primary fixative for at least 17 years without noticeable degradation, do not compromise the ability to prepare the same samples for standard light microscopic evaluation, and provide tips for orientation of samples that may be necessary for evaluation are provided. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2000 article

Cellular and Molecular Mechanisms of Action of Linuron: An Antiandrogenic Herbicide that Produces Reproductive Malformations in Male Rats

Lambright, C., Ostby, J., Bobseine, K., Wilson, V., Hotchkiss, A. K., Mann, P. C., & Gray, L. E. (2000, August 1). Toxicological Sciences.

By: C. Lambright*, J. Ostby, K. Bobseine, V. Wilson*, A. Hotchkiss*, P. Mann*, L. Gray

author keywords: androgen binding; flutamide; linuron; reproductive malformations; androgen receptor (AR) antagonists
MeSH headings : Abnormalities, Drug-Induced; Androgen Antagonists / toxicity; Animals; COS Cells; Dibutyl Phthalate / toxicity; Dihydrotestosterone / pharmacology; Dose-Response Relationship, Drug; Female; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / pathology; Herbicides / toxicity; Linuron / toxicity; Male; Pregnancy; Rats; Rats, Sprague-Dawley; Transcriptional Activation / drug effects
topics (OpenAlex): Sexual Differentiation and Disorders; Hormonal and reproductive studies; Reproductive Biology and Fertility
TL;DR: The hypothesis that linuron is an AR antagonist both in vivo and in vitro is supported, but it remains to be determined if linuron alters sexual differentiation by additional mechanisms of action. (via Semantic Scholar)
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1998 article

Spontaneous and Chemically Induced Proliferative Lesions in Tg.AC Transgenic and p53-Heterozygous Mice

Mahler, J. F., Flagler, N. D., Malarkey, D. E., Mann, P. C., Haseman, J. K., & Eastin, W. (1998, July 1). Toxicologic Pathology.

By: J. Mahler*, N. Flagler *, D. Malarkey n, P. Mann*, J. Haseman* & W. Eastin*

author keywords: mice; genetically altered; hazard identification; neoplasms; carcinogenicity
MeSH headings : Animals; Carcinogenicity Tests / methods; Carcinogens / toxicity; Genes, p53 / genetics; Heterozygote; Mice; Mice, Transgenic / genetics; Mice, Transgenic / physiology; Neoplasms, Experimental / chemically induced; Neoplasms, Experimental / genetics; Neoplasms, Experimental / pathology
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; Cancer-related Molecular Pathways; Animal Genetics and Reproduction
TL;DR: The proliferative target organ effects observed in this set of studies are described and the tumor profile in the control groups of this data set is presented to provide a comprehensive toxicologic assessment. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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