Andrew K. Hotchkiss

Works (17)

Updated: August 20th, 2023 21:15

2010 journal article

In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats

Toxicological Sciences, 114(1), 133–148.

By: B. Ryan, A. Hotchkiss, K. Crofton & L. Gray

Source: NC State University Libraries
Added: August 6, 2018

2009 article

Cumulative Effects of In Utero Administration of Mixtures of “Antiandrogens” on Male Rat Reproductive Development

Rider, C. V., Wilson, V. S., Howdeshell, K. L., Hotchkiss, A. K., Furr, J. R., Lambright, C. R., & Gray, L. E. (2009, January 1). Toxicologic Pathology.

By: C. Rider n, V. Wilson, K. Howdeshell, A. Hotchkiss n, J. Furr, C. Lambright, L. Gray

author keywords: reproductive system; male reproduction; endocrine disrupters
MeSH headings : Androgen Antagonists / toxicity; Animals; Bridged Bicyclo Compounds / toxicity; Complex Mixtures / toxicity; Dibutyl Phthalate / toxicity; Diethylhexyl Phthalate / toxicity; Drug Combinations; Drug Synergism; Female; Fungicides, Industrial / toxicity; Genital Diseases, Male / chemically induced; Genital Diseases, Male / embryology; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Hypospadias / chemically induced; Male; Maternal Exposure; Oxazoles / toxicity; Phthalic Acids / toxicity; Pregnancy; Rats; Receptors, Androgen / drug effects; Receptors, Androgen / metabolism; Sexual Maturation / drug effects
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Toxic Organic Pollutants Impact; Per- and polyfluoroalkyl substances research
TL;DR: The results indicate that compounds that act by disparate mechanisms of toxicity display cumulative, dose-additive effects when present in combination. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 article

Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs

Sternberg, R. M., Gooding, M. P., Hotchkiss, A. K., & LeBlanc, G. A. (2009, August 3). Ecotoxicology, Vol. 19, pp. 4–23.

By: R. Sternberg n, M. Gooding n, A. Hotchkiss n & G. LeBlanc n 

author keywords: Mollusk; Endocrinology; Tributyltin; Imposex; Retinoid X-receptor
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Female; Male; Models, Biological; Photoperiod; Retinoid X Receptors / metabolism; Sex Characteristics; Sex Differentiation / drug effects; Signal Transduction / drug effects; Snails / drug effects; Snails / physiology; Temperature; Tretinoin / metabolism; Trialkyltin Compounds / metabolism; Trialkyltin Compounds / toxicity
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Marine Ecology and Invasive Species
TL;DR: A cohesive model is provided for the environmental-endocrine regulation of reproduction in gastropods and it is proposed that TBT causes imposex through the inappropriate activation of this signaling pathway. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner

Howdeshell, K. L., Wilson, V. S., Furr, J., Lambright, C. R., Rider, C. V., Blystone, C. R., … Gray, L. E. (2008, April 14). Toxicological Sciences.

By: K. Howdeshell*, V. Wilson  n, J. Furr n, C. Lambright n, C. Rider n, C. Blystone n, A. Hotchkiss n, L. Gray n

author keywords: androgens; prenatal; reproductive tract; phthalates; cumulative risk; structure activity relationship
MeSH headings : Animals; Body Weight / drug effects; Dibutyl Phthalate / analogs & derivatives; Dibutyl Phthalate / toxicity; Diethylhexyl Phthalate / toxicity; Dose-Response Relationship, Drug; Female; Fetus / drug effects; Logistic Models; Male; Phthalic Acids / toxicity; Pregnancy; Rats; Rats, Sprague-Dawley; Testis / drug effects; Testis / metabolism; Testosterone / biosynthesis
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Toxic Organic Pollutants Impact; Carcinogens and Genotoxicity Assessment
TL;DR: It is demonstrated that individual phthalates with a similar mechanism of action can elicit cumulative, dose additive effects on fetal testosterone production and pregnancy when administered as a mixture. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 article

Diverse mechanisms of anti‐androgen action: impact on male rat reproductive tract development

Wilson, V. S., Blystone, C. R., Hotchkiss, A. K., Rider, C. V., & Gray, L. E. (2008, March 3). International Journal of Andrology.

By: V. Wilson *, C. Blystone n, A. Hotchkiss n, C. Rider n & L. Gray*

author keywords: androgen receptor; anti-androgen; linuron; phthalate; prochloraz; reproductive development; vinclozolin
MeSH headings : Androgen Antagonists / pharmacology; Animals; Genitalia, Male / drug effects; Genitalia, Male / embryology; Male; Rats
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Toxic Organic Pollutants Impact; Carcinogens and Genotoxicity Assessment
TL;DR: As more and more molecular studies with anti-androgenic compounds are conducted, the number of mechanisms by which compounds can affect the androgen signalling pathway is likely to increase. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 article

Environmental cues trigger seasonal regression of primary and accessory sex organs of the mud snail, Ilyanassa obsoleta

Hotchkiss, A. K., Sternberg, R. M., & LeBlanc, G. A. (2008, April 17). Journal of Molluscan Studies, Vol. 74, pp. 301–303.

By: A. Hotchkiss*, R. Sternberg* & G. LeBlanc* 

topics (OpenAlex): Mollusks and Parasites Studies; Parasite Biology and Host Interactions
TL;DR: Whether the seasonal onset of regression in mud snails is controlled by two environmental cues, photoperiod or temperature is investigated, which is an accurate predictor of changing seasons. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Of Mice and Men (and Mosquitofish): Antiandrogens and Androgens in the Environment

Hotchkiss, A. K., Ankley, G. T., Wilson, V. S., Hartig, P. C., Durhan, E. J., Jensen, K. M., … Gray, L. E. (2008, December 1). BioScience.

By: A. Hotchkiss*, G. Ankley, V. Wilson *, P. Hartig*, E. Durhan, K. Jensen, D. Martinovi, L. Gray

author keywords: androgens; vertebrates; reproductive development; environmental chemicals; antiandrogens
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Reproductive biology and impacts on aquatic species; Pharmaceutical and Antibiotic Environmental Impacts
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 article

Synchronized Expression of Retinoid X Receptor mRNA with Reproductive Tract Recrudescence in an Imposex-Susceptible Mollusc

Sternberg, R. M., Hotchkiss, A. K., & LeBlanc, G. A. (2008, January 16). Environmental Science & Technology, Vol. 42, pp. 1345–1351.

By: R. Sternberg n, A. Hotchkiss n & G. LeBlanc n 

MeSH headings : Amino Acid Sequence; Animals; Female; Male; Molecular Sequence Data; Mollusca / anatomy & histology; Phylogeny; RNA, Messenger / genetics; Reproduction; Retinoid X Receptors / chemistry; Retinoid X Receptors / genetics; Sequence Homology, Amino Acid; Species Specificity
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Marine Ecology and Invasive Species
TL;DR: Results demonstrate that RXR expression is associated with reproductive tract recrudescence in both sexes; although, the timing of recrUDescence may dictate sex-specific development. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

The contribution of steroidal androgens and estrogens to reproductive maturation of the eastern mud snail Ilyanassa obsoleta

Sternberg, R. M., Hotchkiss, A. K., & LeBlanc, G. A. (2008, January 30). General and Comparative Endocrinology, Vol. 156, pp. 15–26.

By: R. Sternberg n, A. Hotchkiss n & G. LeBlanc n 

author keywords: androgens; estrogens; retinoids; neogastropod; gastropod; imposex; tributyltin; bisphenol A
MeSH headings : Amino Acid Sequence; Androgens / physiology; Animals; Estradiol / metabolism; Estrogens / physiology; Female; Male; Molecular Sequence Data; Phylogeny; RNA, Messenger / metabolism; Receptors, Androgen / metabolism; Receptors, Estrogen / analysis; Receptors, Estrogen / metabolism; Reproduction / physiology; Sexual Maturation / physiology; Snails / physiology; Testosterone / metabolism
topics (OpenAlex): Marine Biology and Environmental Chemistry; Environmental Toxicology and Ecotoxicology; Reproductive biology and impacts on aquatic species
TL;DR: In conclusion, testosterone may have a role in male reproductive tract recrudescence; however, this putative activity is independent of a NR3C4-type androgen receptor. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 article

Prenatal Testosterone Exposure Permanently Masculinizes Anogenital Distance, Nipple Development, and Reproductive Tract Morphology in Female Sprague-Dawley Rats

Hotchkiss, A. K., Lambright, C. S., Ostby, J. S., Parks-Saldutti, L., Vandenbergh, J. G., & Gray, L. E. (2006, October 31). Toxicological Sciences.

By: A. Hotchkiss n, C. Lambright*, J. Ostby*, L. Parks-Saldutti*, J. Vandenbergh n & L. Gray*

author keywords: AGD; areola; masculinization; reproductive development; fetal androgen; intrauterine position
MeSH headings : Abnormalities, Drug-Induced / etiology; Abnormalities, Drug-Induced / pathology; Anal Canal / abnormalities; Anal Canal / drug effects; Animals; Animals, Newborn / abnormalities; Endocrine Disruptors / chemistry; Endocrine Disruptors / toxicity; Estrus / drug effects; Estrus / physiology; Female; Fetus / abnormalities; Fetus / drug effects; Genitalia, Female / abnormalities; Genitalia, Female / drug effects; Gestational Age; Male; Nipples / drug effects; Nipples / embryology; Nipples / growth & development; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Testosterone / chemistry; Testosterone / toxicity; Uterus / abnormalities; Uterus / drug effects; Vagina / abnormalities; Vagina / drug effects; Weight Loss / drug effects
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Birth, Development, and Health; Reproductive Biology and Fertility
TL;DR: TP-induced changes in neonatal AGD and infant areola number were reliable indicators of permanently altered adult phenotype in female Rats, and females in the two high-dose groups displayed increased incidences of external genital malformations and the presence of prostatic tissue, not normally found in female rats. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

The anogenital distance index of mice (Mus musculus domesticus): An analysis

Contemporary Topics in Laboratory Animal Science, 44(4), 46–48.

By: A. Hotchkiss & J. Vandenbergh

Source: NC State University Libraries
Added: August 6, 2018

2004 article

A Mixture of the “Antiandrogens” Linuron and Butyl Benzyl Phthalate Alters Sexual Differentiation of the Male Rat in a Cumulative Fashion1

Hotchkiss, A. K., Parks-Saldutti, L. G., Ostby, J. S., Lambright, C., Furr, J., Vandenbergh, J. G., & Gray, L. E. (2004, October 20). Biology of Reproduction.

By: A. Hotchkiss*, L. Parks-Saldutti*, J. Ostby*, C. Lambright*, J. Furr*, J. Vandenbergh n, L. Gray *

author keywords: androgen receptor; male reproductive tract; male sexual function; testosterone; toxicology
MeSH headings : Anal Canal / anatomy & histology; Androgen Antagonists / administration & dosage; Androgen Antagonists / pharmacology; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Fetus / metabolism; Genitalia, Male / anatomy & histology; Genitalia, Male / embryology; Linuron / administration & dosage; Linuron / pharmacology; Male; Osmolar Concentration; Phthalic Acids / administration & dosage; Phthalic Acids / pharmacology; Pregnancy; Prenatal Exposure Delayed Effects; Progesterone / metabolism; Rats; Rats, Sprague-Dawley; Sex Differentiation / drug effects; Testis / metabolism; Testosterone / metabolism
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Toxic Organic Pollutants Impact; Birth, Development, and Health
TL;DR: Treatment-related changes to neonatal AGD and infant areolae significantly correlated with adult AGD, nipple retention, reproductive malformations, and reproductive organ and tissue weights provide additional evidence of cumulative effects of antiandrogen mixtures on male reproductive development. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 article

Effects of Prenatal Testosterone Propionate on the Sexual Development of Male and Female Rats: A Dose-Response Study

Wolf, C. J., Hotchkiss, A., Ostby, J. S., LeBlanc, G., & Gray, L. E. (2002, January 1). Toxicological Sciences, Vol. 65, pp. 71–86.

By: C. Wolf*, A. Hotchkiss, J. Ostby, G. LeBlanc  & L. Gray

author keywords: testosterone propionate; androgens; masculinization; prenatal exposure; sexual differentiation; anogenital distance; agenesis of the lower vagina; Sprague-Dawley rats
MeSH headings : Abnormalities, Drug-Induced / etiology; Anal Canal / abnormalities; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Genitalia, Female / abnormalities; Genitalia, Male / abnormalities; Gonadal Steroid Hormones / administration & dosage; Gonadal Steroid Hormones / physiology; Gonadal Steroid Hormones / toxicity; Male; Maternal Exposure / adverse effects; Nipples / abnormalities; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Testosterone / administration & dosage; Testosterone / physiology; Testosterone / toxicity; Toxicity Tests; Vagina / abnormalities
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Sexual Differentiation and Disorders; Hormonal and reproductive studies
TL;DR: Gestation administration of 0.5 and 1 mg TP masculinizes female offspring without greatly affecting pup viability or pregnancy of the dam, and this study provides a useful model for in utero testing of environmental androgens for their potential to induce developmental abnormalities. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 patent

Altering sex ratio of offspring in mammals

Washington, DC: U.S. Patent and Trademark Office.

By: J. Vandenbergh, J. Konzelmann & A. Hotchkiss

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Cellular and Molecular Mechanisms of Action of Linuron: An Antiandrogenic Herbicide that Produces Reproductive Malformations in Male Rats

Lambright, C., Ostby, J., Bobseine, K., Wilson, V., Hotchkiss, A. K., Mann, P. C., & Gray, L. E. (2000, August 1). Toxicological Sciences.

By: C. Lambright*, J. Ostby, K. Bobseine, V. Wilson*, A. Hotchkiss*, P. Mann*, L. Gray

author keywords: androgen binding; flutamide; linuron; reproductive malformations; androgen receptor (AR) antagonists
MeSH headings : Abnormalities, Drug-Induced; Androgen Antagonists / toxicity; Animals; COS Cells; Dibutyl Phthalate / toxicity; Dihydrotestosterone / pharmacology; Dose-Response Relationship, Drug; Female; Genitalia, Male / abnormalities; Genitalia, Male / drug effects; Genitalia, Male / pathology; Herbicides / toxicity; Linuron / toxicity; Male; Pregnancy; Rats; Rats, Sprague-Dawley; Transcriptional Activation / drug effects
topics (OpenAlex): Sexual Differentiation and Disorders; Hormonal and reproductive studies; Reproductive Biology and Fertility
TL;DR: The hypothesis that linuron is an AR antagonist both in vivo and in vitro is supported, but it remains to be determined if linuron alters sexual differentiation by additional mechanisms of action. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Environmental antiandrogens: The malformation pattern varies with the mechanism of antiandrogenic action.

Biology of Reproduction, 60(1999), 201.

By: L. Gray, M. Price, C. Lambright, C. Wolf, A. Hotchkiss, L. Parks, J. Ostby

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Exposure to bisphenol A advances puberty

Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G., & Saal, F. S. (1999, October 1). Nature.

By: K. Howdeshell *, A. Hotchkiss n, K. Thayer *, J. Vandenbergh n & F. Saal*

MeSH headings : Animals; Benzhydryl Compounds; Body Weight / drug effects; Estrogens, Non-Steroidal / pharmacology; Female; Fetus / drug effects; Humans; Male; Mice; Models, Biological; Phenols / pharmacology; Pregnancy; Prenatal Exposure Delayed Effects; Sexual Maturation / drug effects
topics (OpenAlex): Effects and risks of endocrine disrupting chemicals; Toxic Organic Pollutants Impact
TL;DR: It is shown that exposing female mouse fetuses to an EEDC at a dose that is within the range typical of the environmental exposure of humans alters the postnatal growth rate and brings on early puberty in these mice. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.