Christine C. Nelson

Works (1)

Updated: July 5th, 2023 16:02

2000 journal article

A single deletion in the membrane-proximal region of the Sindbis virus glycoprotein E2 endodomain blocks virus assembly

JOURNAL OF VIROLOGY, 74(9), 4220–4228.

By: R. Hernandez n, H. Lee *, C. Nelson n & D. Brown n

MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Biological Transport; Cell Line; Cell Membrane / metabolism; Cricetinae; Cytoplasm / metabolism; Humans; Intracellular Fluid / metabolism; Molecular Sequence Data; Mutagenesis; Nucleocapsid / metabolism; Sindbis Virus / genetics; Sindbis Virus / physiology; Sindbis Virus / ultrastructure; Viral Envelope Proteins / genetics; Viral Envelope Proteins / metabolism; Viral Envelope Proteins / physiology; Viral Structural Proteins / metabolism; Virus Assembly / physiology
TL;DR: A deletion mutant is constructed, ΔK391, in which a nonconserved lysine at the membrane-cytoplasm junction of the E2 tail has been deleted and it is proposed that the phenotypic differences displayed by this mutant in the two diverse host cells arise from fundamental differences in the lipid composition of the insect cell membranes. (via Semantic Scholar)
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