Works (1)
Updated: July 5th, 2023 15:58
2004 journal article
Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia
AMERICAN JOURNAL OF VETERINARY RESEARCH, 65(6), 761–769.
Contributors: J. Tomlinson n, O. Wilder n, K. Young n & A. Blikslager n
MeSH headings : Animals; Biological Transport; Blotting, Western; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Eicosanoids / metabolism; Electric Impedance; Epithelium / blood supply; Etodolac / pharmacokinetics; Etodolac / therapeutic use; Gene Expression; Histological Techniques; Horse Diseases / drug therapy; Horses; Ischemia / drug therapy; Ischemia / veterinary; Isoenzymes / metabolism; Jejunum / blood supply; Mannitol; Neutrophils; Pain Measurement / veterinary; Prostaglandin-Endoperoxide Synthases / metabolism; Reperfusion / veterinary; Time Factors; Tritium
TL;DR:
Flunixin and etodolac treatment retarded recovery of intestinal barrier function in jejunal mucosa after 18 hours of reperfusion, whereas tissues from horses treated with saline solution recovered baseline values of TER and permeability to mannitol.
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Added: August 6, 2018