2004 journal article

Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia

AMERICAN JOURNAL OF VETERINARY RESEARCH, 65(6), 761–769.

By: J. Tomlinson n, B. Wilder n, K. Young n & A. Blikslager n

Contributors: J. Tomlinson n, O. Wilder n, K. Young n & A. Blikslager n

MeSH headings : Animals; Biological Transport; Blotting, Western; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Eicosanoids / metabolism; Electric Impedance; Epithelium / blood supply; Etodolac / pharmacokinetics; Etodolac / therapeutic use; Gene Expression; Histological Techniques; Horse Diseases / drug therapy; Horses; Ischemia / drug therapy; Ischemia / veterinary; Isoenzymes / metabolism; Jejunum / blood supply; Mannitol; Neutrophils; Pain Measurement / veterinary; Prostaglandin-Endoperoxide Synthases / metabolism; Reperfusion / veterinary; Time Factors; Tritium
TL;DR: Flunixin and etodolac treatment retarded recovery of intestinal barrier function in jejunal mucosa after 18 hours of reperfusion, whereas tissues from horses treated with saline solution recovered baseline values of TER and permeability to mannitol. (via Semantic Scholar)
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