Yunxin Huang

Works (8)

Updated: July 16th, 2023 21:18

2010 journal article

Medea selfish genetic elements as tools for altering traits of wild populations: A theoretical analysis.

Evolution, 65(4), 1149–1162.

By: C. Ward*, J. Su*, Y. Huang n, A. Lloyd n , F. Gould n  & B. Hay *

author keywords: Dengue; introgression; malaria; maternal effect; mosquito; population replacement
MeSH headings : Animals; Culicidae / genetics; Disease Transmission, Infectious / prevention & control; Female; Fertility / genetics; Genetic Fitness / genetics; Genetics, Population; Genotype; Insect Vectors / genetics; Male; Models, Genetic; Repetitive Sequences, Nucleic Acid / genetics; Transgenes / genetics
topics (OpenAlex): Insect symbiosis and bacterial influences; Evolution and Genetic Dynamics; Insect behavior and control techniques
TL;DR: This work derives equations that describe the conditions under which Medea elements with fitness costs will spread, and the equilibrium allele frequencies are achieved, and suggests that medea elements can drive population replacement under a wide range of conditions. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2009 article

Density-Dependent Intraspecific Competition in the Larval Stage ofAedes aegypti(Diptera: Culicidae): Revisiting the Current Paradigm

Legros, M., Lloyd, A. L., Huang, Y., & Gould, F. (2009, May 1). Journal of Medical Entomology, Vol. 46, pp. 409–419.

By: M. Legros n, A. Lloyd* , Y. Huang n & F. Gould n 

author keywords: Aedes aegypti; density dependence; intraspecific competition; mathematical model; parameter estimation
MeSH headings : Aedes / growth & development; Aedes / physiology; Animals; Behavior, Animal; Competitive Behavior; Environment; Feeding Behavior; Larva / growth & development; Larva / physiology; Models, Theoretical; Population Density; Population Dynamics
topics (OpenAlex): Mosquito-borne diseases and control; Malaria Research and Control; Mathematical and Theoretical Epidemiology and Ecology Models
TL;DR: It is emphasized that the characterization of density dependence in the larval stages of Ae. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

A Killer–Rescue system for self-limiting gene drive of anti-pathogen constructs

Gould, F., Huang, Y., Legros, M., & Lloyd, A. L. (2008, September 2). Proceedings of the Royal Society B Biological Sciences, Vol. 275, pp. 2823–2829.

By: F. Gould n , Y. Huang n, M. Legros n & A. Lloyd n 

author keywords: gene drive; selfish genes; Aedes; Anopheles; dengue; malaria
MeSH headings : Alleles; Animals; Culicidae / genetics; Culicidae / parasitology; Culicidae / virology; Disease Transmission, Infectious / prevention & control; Gene Frequency; Genes, Lethal; Genetic Engineering / methods; Genotype; Inheritance Patterns; Insect Vectors / genetics; Insect Vectors / parasitology; Insect Vectors / virology; Models, Genetic; Transgenes
topics (OpenAlex): CRISPR and Genetic Engineering; Viral Infectious Diseases and Gene Expression in Insects; Bacteriophages and microbial interactions
TL;DR: A gene-drive mechanism that can be self-limiting over time and space, and is simpler to build is proposed, which involves one gene that codes for toxicity (killer) and a second that confers immunity to the toxic effects (rescue). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Gene-drive in age-structured insect populations

Evolutionary Applications, 2(2), 143–159.

By: Y. Huang n, A. Lloyd n , M. Legros n & F. Gould n 

author keywords: assortative mating; fitness cost; genetic control; mosquito; release threshold
topics (OpenAlex): CRISPR and Genetic Engineering; Insect symbiosis and bacterial influences; Insect behavior and control techniques
TL;DR: It is found that models without age‐structure and mating details can substantially overestimate or underestimate the numbers of engineered insects that must be introduced into a wild population to achieve successful gene‐drive based on the Medea and engineered underdominance mechanisms. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2007 article

INTRODUCING DESIRABLE TRANSGENES INTO INSECT POPULATIONS USING Y-LINKED MEIOTIC DRIVE?A THEORETICAL ASSESSMENT

Huang, Y., Magori, K., Lloyd, A. L., & Gould, F. (2007, March 22). Evolution, Vol. 61, pp. 717–726.

By: Y. Huang n, K. Magori n, A. Lloyd n  & F. Gould n 

author keywords: autosomal modifier; sex-ratio distortion; transgene; X-chromosome responder; Y-chromosome driver
MeSH headings : Aedes / genetics; Alleles; Animals; Computer Simulation; Gene Transfer Techniques; Genetic Engineering / methods; Genetics, Population; Insect Vectors / genetics; Male; Meiosis; Models, Genetic; Parasitic Diseases / prevention & control; Transgenes / genetics
topics (OpenAlex): Insect symbiosis and bacterial influences; Insect Resistance and Genetics; Mosquito-borne diseases and control
TL;DR: This work theoretically assesses the feasibility of introducing antipathogen genes into wild Aedes aegypti populations by using a naturally occurring meiotic drive system and uses mathematical models and computer simulations to determine how the post-introduction dynamics of the antipathogenic gene are affected by specific genetic characteristics of the system. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 article

Introducing transgenes into insect populations using combined gene-drive strategies: Modeling and analysis

Huang, Y., Magori, K., Lloyd, A. L., & Gould, F. (2007, June 14). Insect Biochemistry and Molecular Biology, Vol. 37, pp. 1054–1063.

By: Y. Huang n, K. Magori  n, A. Lloyd n  & F. Gould n 

author keywords: insect vectors; anti-pathogen transgene; gene-drive; combined strategy; release threshold; theoretical assessment
MeSH headings : Animals; Animals, Genetically Modified; Computer Simulation; Female; Insect Control; Insect Vectors / genetics; Male; Meiosis / genetics; Models, Genetic; Transgenes; Wolbachia / genetics
topics (OpenAlex): Insect symbiosis and bacterial influences; CRISPR and Genetic Engineering; Insect behavior and control techniques
TL;DR: Under some conditions, the combination of EU and MD results in a more efficient transgene-drive strategy than either mechanism alone, and this combined strategy could drive the transgenes to stable fixation and would require fewer released insects than EU alone. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Age-structured effects and disease interference in childhood infections

Proceedings of the Royal Society of London. Series B. Biological Sciences, 273(1591), 1229–1237.

By: Y. Huang & P. Rohani

Source: NC State University Libraries
Added: August 6, 2018

2006 article

Genetic Strategies for Controlling Mosquito-Borne Diseases

Gould, F., Magori, K., & Huang, Y. (2006, January 1). American Scientist, Vol. 94, pp. 238–246.

By: F. Gould* , K. Magori* & Y. Huang*

topics (OpenAlex): Mosquito-borne diseases and control; Insect Resistance and Genetics
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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