Works (8)
Updated: July 16th, 2023 21:18
2010 journal article
Medea selfish genetic elements as tools for altering traits of wild populations: A theoretical analysis.
Evolution, 65(4), 1149–1162.
author keywords: Dengue; introgression; malaria; maternal effect; mosquito; population replacement
MeSH headings : Animals; Culicidae / genetics; Disease Transmission, Infectious / prevention & control; Female; Fertility / genetics; Genetic Fitness / genetics; Genetics, Population; Genotype; Insect Vectors / genetics; Male; Models, Genetic; Repetitive Sequences, Nucleic Acid / genetics; Transgenes / genetics
TL;DR:
This work derives equations that describe the conditions under which Medea elements with fitness costs will spread, and the equilibrium allele frequencies are achieved, and suggests that medea elements can drive population replacement under a wide range of conditions.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2009 journal article
Density-Dependent Intraspecific Competition in the Larval Stage of Aedes aegypti (Diptera: Culicidae): Revisiting the Current Paradigm
JOURNAL OF MEDICAL ENTOMOLOGY, 46(3), 409–419.
author keywords: Aedes aegypti; density dependence; intraspecific competition; mathematical model; parameter estimation
MeSH headings : Aedes / growth & development; Aedes / physiology; Animals; Behavior, Animal; Competitive Behavior; Environment; Feeding Behavior; Larva / growth & development; Larva / physiology; Models, Theoretical; Population Density; Population Dynamics
TL;DR:
It is emphasized that the characterization of density dependence in the larval stages of Ae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
A Killer-Rescue system for self-limiting gene drive of anti-pathogen constructs
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 275(1653), 2823–2829.
author keywords: gene drive; selfish genes; Aedes; Anopheles; dengue; malaria
MeSH headings : Alleles; Animals; Culicidae / genetics; Culicidae / parasitology; Culicidae / virology; Disease Transmission, Infectious / prevention & control; Gene Frequency; Genes, Lethal; Genetic Engineering / methods; Genotype; Inheritance Patterns; Insect Vectors / genetics; Insect Vectors / parasitology; Insect Vectors / virology; Models, Genetic; Transgenes
TL;DR:
A gene-drive mechanism that can be self-limiting over time and space, and is simpler to build is proposed, which involves one gene that codes for toxicity (killer) and a second that confers immunity to the toxic effects (rescue).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Gene-drive in age-structured insect populations
Evolutionary Applications, 2(2), 143–159.
author keywords: assortative mating; fitness cost; genetic control; mosquito; release threshold
TL;DR:
It is found that models without age‐structure and mating details can substantially overestimate or underestimate the numbers of engineered insects that must be introduced into a wild population to achieve successful gene‐drive based on the Medea and engineered underdominance mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2007 journal article
Introducing desirable transgenes into insect populations using Y-linked meiotic drive - A theoretical assessment
EVOLUTION, 61(4), 717–726.
author keywords: autosomal modifier; sex-ratio distortion; transgene; X-chromosome responder; Y-chromosome driver
MeSH headings : Aedes / genetics; Alleles; Animals; Computer Simulation; Gene Transfer Techniques; Genetic Engineering / methods; Genetics, Population; Insect Vectors / genetics; Male; Meiosis; Models, Genetic; Parasitic Diseases / prevention & control; Transgenes / genetics
TL;DR:
This work theoretically assesses the feasibility of introducing antipathogen genes into wild Aedes aegypti populations by using a naturally occurring meiotic drive system and uses mathematical models and computer simulations to determine how the post-introduction dynamics of the antipathogenic gene are affected by specific genetic characteristics of the system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Introducing transgenes into insect populations using combined gene-drive strategies: Modeling and analysis
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 37(10), 1054–1063.
author keywords: insect vectors; anti-pathogen transgene; gene-drive; combined strategy; release threshold; theoretical assessment
MeSH headings : Animals; Animals, Genetically Modified; Computer Simulation; Female; Insect Control; Insect Vectors / genetics; Male; Meiosis / genetics; Models, Genetic; Transgenes; Wolbachia / genetics
TL;DR:
Under some conditions, the combination of EU and MD results in a more efficient transgene-drive strategy than either mechanism alone, and this combined strategy could drive the transgenes to stable fixation and would require fewer released insects than EU alone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Age-structured effects and disease interference in childhood infections
Proceedings of the Royal Society of London. Series B. Biological Sciences, 273(1591), 1229–1237.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Genetic strategies for controlling mosquito-borne diseases
AMERICAN SCIENTIST, 94(3), 238–246.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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