Works (13)
Updated: July 16th, 2023 21:18
2020 review
Resistance to natural and synthetic gene drive systems
[Review of ]. JOURNAL OF EVOLUTIONARY BIOLOGY, 33(10), 1345–1360.
author keywords: CRISPR-Cas9; fitness costs; meiotic drive; population suppression; selfish genetic elements; sex ratio distorter; transposable element; Wolbachia
MeSH headings : Biological Evolution; Gene Drive Technology; Selection, Genetic
TL;DR:
This review summarizes the current knowledge of drive resistance in both natural and synthetic gene drives and explores how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020
2016 journal article
Comparison of two detailed models of Aedes aegypti population dynamics
Ecosphere, 7(10), e01515.
author keywords: Aedes aegypti; model comparison; mosquito-borne diseases; population dynamics; spatial model; vector control
TL;DR:
It is shown that predictions of population recovery by the models differ substantially, an effect likely related to model assumptions regarding larval development and (direct or delayed) density dependence, and revealing the impact of model assumptions on population dynamics predictions in unperturbed and perturbed conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2013 journal article
Modeling the Dynamics of a Non-Limited and a Self-Limited Gene Drive System in Structured Aedes aegypti Populations
PLoS ONE, 8(12), e83354.
Ed(s): Z. Adelman
MeSH headings : Aedes / genetics; Animals; Animals, Genetically Modified / genetics; Dengue / genetics; Dengue / prevention & control; Dengue / transmission; Female; Gene Frequency; Genetic Engineering; Genetics, Population; Homozygote; Insect Vectors / genetics; Male; Models, Genetic; Mosquito Control; Peru; Population Dynamics; Time Factors
TL;DR:
This study provides guidelines for operational approaches to population replacement genetic strategies, as well as illustrates the use of detailed spatial models to assist in safe and efficient implementation of such novel genetic strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Assessing the Feasibility of Controlling Aedes aegypti with Transgenic Methods: A Model-Based Evaluation
PLoS ONE, 7(12), e52235.
Ed(s): N. Vasilakis
MeSH headings : Aedes / genetics; Aedes / physiology; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / physiology; Mosquito Control; Peru
TL;DR:
It is demonstrated that substantial suppression can nonetheless be achieved if releases are deployed in a uniform spatial pattern using strains combining multiple lethal elements, illustrating the importance of detailed spatial models for guiding genetic mosquito control strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2011 journal article
Evaluation of Location-Specific Predictions by a Detailed Simulation Model of Aedes aegypti Populations
PLoS ONE, 6(7), e22701.
Ed(s): E. Ooi
MeSH headings : Aedes; Animals; Argentina; Female; Models, Theoretical; Population Dynamics; Stochastic Processes; Time Factors
TL;DR:
The results show that Skeeter Buster replicates specific population dynamics and spatial structure of Ae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2010 journal article
Experimental evolution of specialization by a microsporidian parasite
BMC Evolutionary Biology, 10.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Gene-drive into insect populations with age and spatial structure: a theoretical assessment
Evolutionary Applications, 4(3), 415–428.
author keywords: age and spatial structure; engineered underdominance; gene drive; release threshold; theoretical assessment
TL;DR:
This study demonstrates that to determine the best method of spatial release, and the total number of engineered insects that must be released, it is important to take into account the age and sex of the released insects and spatial structure of the population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2010 journal article
Insect oviposition behavior affects the evolution of adaptation to Bt crops: consequences for refuge policies
EVOLUTIONARY ECOLOGY, 24(5), 1017–1030.
author keywords: Behavioral resistance; Physiological resistance; Bt crop; Monitoring; Host specificity; Host shift
TL;DR:
It is demonstrated that certain ecological conditions allow for the evolution of behavioral choices favoring alternative oviposition hosts that limit the increase in resistance alleles, even when they are phenotypically dominant.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Understanding Uncertainties in Model-Based Predictions of Aedes aegypti Population Dynamics
PLoS Neglected Tropical Diseases, 4(9), e830.
Ed(s): S. O'Neill
MeSH headings : Aedes / growth & development; Animals; Disease Vectors; Female; Geography; Housing; Humans; Male; Models, Statistical; Peru; Population Density; Population Dynamics
TL;DR:
This is the first systematic uncertainty analysis of a detailed Ae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2009 journal article
Density-Dependent Intraspecific Competition in the Larval Stage of Aedes aegypti (Diptera: Culicidae): Revisiting the Current Paradigm
JOURNAL OF MEDICAL ENTOMOLOGY, 46(3), 409–419.
author keywords: Aedes aegypti; density dependence; intraspecific competition; mathematical model; parameter estimation
MeSH headings : Aedes / growth & development; Aedes / physiology; Animals; Behavior, Animal; Competitive Behavior; Environment; Feeding Behavior; Larva / growth & development; Larva / physiology; Models, Theoretical; Population Density; Population Dynamics
TL;DR:
It is emphasized that the characterization of density dependence in the larval stages of Ae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Gene-drive in age-structured insect populations
Evolutionary Applications, 2(2), 143–159.
author keywords: assortative mating; fitness cost; genetic control; mosquito; release threshold
TL;DR:
It is found that models without age‐structure and mating details can substantially overestimate or underestimate the numbers of engineered insects that must be introduced into a wild population to achieve successful gene‐drive based on the Medea and engineered underdominance mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2009 journal article
Skeeter Buster: A Stochastic, Spatially Explicit Modeling Tool for Studying Aedes aegypti Population Replacement and Population Suppression Strategies
PLoS Neglected Tropical Diseases, 3(9), e508.
Ed(s): P. Kittayapong
TL;DR:
A new modeling tool of Ae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
A Killer-Rescue system for self-limiting gene drive of anti-pathogen constructs
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 275(1653), 2823–2829.
author keywords: gene drive; selfish genes; Aedes; Anopheles; dengue; malaria
MeSH headings : Alleles; Animals; Culicidae / genetics; Culicidae / parasitology; Culicidae / virology; Disease Transmission, Infectious / prevention & control; Gene Frequency; Genes, Lethal; Genetic Engineering / methods; Genotype; Inheritance Patterns; Insect Vectors / genetics; Insect Vectors / parasitology; Insect Vectors / virology; Models, Genetic; Transgenes
TL;DR:
A gene-drive mechanism that can be self-limiting over time and space, and is simpler to build is proposed, which involves one gene that codes for toxicity (killer) and a second that confers immunity to the toxic effects (rescue).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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