Mathieu Legros

Works (13)

Updated: July 16th, 2023 21:18

2020 article

Resistance to natural and synthetic gene drive systems

Price, T. A. R., Windbichler, N., Unckless, R. L., Sutter, A., Runge, J. N., Ross, P. A., … Lindholm, A. K. (2020, September 24). Journal of Evolutionary Biology.

By: T. Price *, N. Windbichler *, R. Unckless *, A. Sutter *, J. Runge *, P. Ross *, A. Pomiankowski *, N. Nuckolls * ...

author keywords: CRISPR-Cas9; fitness costs; meiotic drive; population suppression; selfish genetic elements; sex ratio distorter; transposable element; Wolbachia
MeSH headings : Biological Evolution; Gene Drive Technology; Selection, Genetic
topics (OpenAlex): CRISPR and Genetic Engineering; Insect symbiosis and bacterial influences; Innovation and Socioeconomic Development
TL;DR: This review summarizes the current knowledge of drive resistance in both natural and synthetic gene drives and explores how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general. (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2016 journal article

Comparison of two detailed models of Aedes aegypti population dynamics

Ecosphere, 7(10), e01515.

By: M. Legros n, M. Otero *, V. Romeo Aznar *, H. Solari *, F. Gould n  & A. Lloyd n 

author keywords: Aedes aegypti; model comparison; mosquito-borne diseases; population dynamics; spatial model; vector control
topics (OpenAlex): Mosquito-borne diseases and control; Insect symbiosis and bacterial influences; Malaria Research and Control; Viral Infections and Vectors
TL;DR: It is shown that predictions of population recovery by the models differ substantially, an effect likely related to model assumptions regarding larval development and (direct or delayed) density dependence, and revealing the impact of model assumptions on population dynamics predictions in unperturbed and perturbed conditions. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

Modeling the Dynamics of a Non-Limited and a Self-Limited Gene Drive System in Structured Aedes aegypti Populations

PLoS ONE, 8(12), e83354.

By: M. Legros n, C. Xu n, A. Morrison *, T. Scott *, A. Lloyd n  & F. Gould n 

Ed(s): Z. Adelman

MeSH headings : Aedes / genetics; Animals; Animals, Genetically Modified / genetics; Dengue / genetics; Dengue / prevention & control; Dengue / transmission; Female; Gene Frequency; Genetic Engineering; Genetics, Population; Homozygote; Insect Vectors / genetics; Male; Models, Genetic; Mosquito Control; Peru; Population Dynamics; Time Factors
topics (OpenAlex): Insect symbiosis and bacterial influences; Mosquito-borne diseases and control; Insect behavior and control techniques
TL;DR: This study provides guidelines for operational approaches to population replacement genetic strategies, as well as illustrates the use of detailed spatial models to assist in safe and efficient implementation of such novel genetic strategies. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2012 journal article

Assessing the Feasibility of Controlling Aedes aegypti with Transgenic Methods: A Model-Based Evaluation

PLoS ONE, 7(12), e52235.

By: M. Legros n, C. Xu n, K. Okamoto n, T. Scott *, A. Morrison *, A. Lloyd n , F. Gould n 

Ed(s): N. Vasilakis

MeSH headings : Aedes / genetics; Aedes / physiology; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / physiology; Mosquito Control; Peru
topics (OpenAlex): Mosquito-borne diseases and control; Insect symbiosis and bacterial influences; Insect behavior and control techniques
TL;DR: It is demonstrated that substantial suppression can nonetheless be achieved if releases are deployed in a uniform spatial pattern using strains combining multiple lethal elements, illustrating the importance of detailed spatial models for guiding genetic mosquito control strategies. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

Evaluation of Location-Specific Predictions by a Detailed Simulation Model of Aedes aegypti Populations

PLoS ONE, 6(7), e22701.

By: M. Legros n, K. Magori*, A. Morrison *, C. Xu n, T. Scott *, A. Lloyd n , F. Gould n 

Ed(s): E. Ooi

MeSH headings : Aedes; Animals; Argentina; Female; Models, Theoretical; Population Dynamics; Stochastic Processes; Time Factors
topics (OpenAlex): Mosquito-borne diseases and control; COVID-19 epidemiological studies; Dengue and Mosquito Control Research
TL;DR: The results show that Skeeter Buster replicates specific population dynamics and spatial structure of Ae. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Experimental evolution of specialization by a microsporidian parasite

BMC Evolutionary Biology, 10.

By: M. Legros & J. Koella

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Gene-drive into insect populations with age and spatial structure: a theoretical assessment

Evolutionary Applications, 4(3), 415–428.

By: Y. Huang  n, A. Lloyd n , M. Legros n & F. Gould n 

author keywords: age and spatial structure; engineered underdominance; gene drive; release threshold; theoretical assessment
topics (OpenAlex): CRISPR and Genetic Engineering; Insect symbiosis and bacterial influences; Insect Resistance and Genetics
TL;DR: This study demonstrates that to determine the best method of spatial release, and the total number of engineered insects that must be released, it is important to take into account the age and sex of the released insects and spatial structure of the population. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 article

Insect oviposition behavior affects the evolution of adaptation to Bt crops: consequences for refuge policies

Jongsma, M. A., Gould, F., Legros, M., Yang, L., Loon, J. J. A., & Dicke, M. (2010, February 17). Evolutionary Ecology, Vol. 24, pp. 1017–1030.

By: M. Jongsma *, F. Gould n , M. Legros n, L. Yang *, J. Loon * & M. Dicke *

author keywords: Behavioral resistance; Physiological resistance; Bt crop; Monitoring; Host specificity; Host shift
topics (OpenAlex): Insect Resistance and Genetics; CRISPR and Genetic Engineering; Insect-Plant Interactions and Control
TL;DR: It is demonstrated that certain ecological conditions allow for the evolution of behavioral choices favoring alternative oviposition hosts that limit the increase in resistance alleles, even when they are phenotypically dominant. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Understanding Uncertainties in Model-Based Predictions of Aedes aegypti Population Dynamics

PLoS Neglected Tropical Diseases, 4(9), e830.

By: C. Xu n, M. Legros n, F. Gould n  & A. Lloyd n 

Ed(s): S. O'Neill

MeSH headings : Aedes / growth & development; Animals; Disease Vectors; Female; Geography; Housing; Humans; Male; Models, Statistical; Peru; Population Density; Population Dynamics
topics (OpenAlex): Mosquito-borne diseases and control; Economic and Environmental Valuation; Ecology and Vegetation Dynamics Studies
TL;DR: This is the first systematic uncertainty analysis of a detailed Ae. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2009 article

Density-Dependent Intraspecific Competition in the Larval Stage ofAedes aegypti(Diptera: Culicidae): Revisiting the Current Paradigm

Legros, M., Lloyd, A. L., Huang, Y., & Gould, F. (2009, May 1). Journal of Medical Entomology, Vol. 46, pp. 409–419.

By: M. Legros n, A. Lloyd* , Y. Huang n & F. Gould n 

author keywords: Aedes aegypti; density dependence; intraspecific competition; mathematical model; parameter estimation
MeSH headings : Aedes / growth & development; Aedes / physiology; Animals; Behavior, Animal; Competitive Behavior; Environment; Feeding Behavior; Larva / growth & development; Larva / physiology; Models, Theoretical; Population Density; Population Dynamics
topics (OpenAlex): Mosquito-borne diseases and control; Malaria Research and Control; Mathematical and Theoretical Epidemiology and Ecology Models
TL;DR: It is emphasized that the characterization of density dependence in the larval stages of Ae. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Skeeter Buster: A Stochastic, Spatially Explicit Modeling Tool for Studying Aedes aegypti Population Replacement and Population Suppression Strategies

PLoS Neglected Tropical Diseases, 3(9), e508.

By: K. Magori n, M. Legros n, M. Puente n , D. Focks, T. Scott *, A. Lloyd n , F. Gould n 

Ed(s): P. Kittayapong

topics (OpenAlex): Mosquito-borne diseases and control; Insect symbiosis and bacterial influences; Malaria Research and Control
TL;DR: A new modeling tool of Ae. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 article

A Killer–Rescue system for self-limiting gene drive of anti-pathogen constructs

Gould, F., Huang, Y., Legros, M., & Lloyd, A. L. (2008, September 2). Proceedings of the Royal Society B Biological Sciences, Vol. 275, pp. 2823–2829.

By: F. Gould n , Y. Huang n, M. Legros n & A. Lloyd n 

author keywords: gene drive; selfish genes; Aedes; Anopheles; dengue; malaria
MeSH headings : Alleles; Animals; Culicidae / genetics; Culicidae / parasitology; Culicidae / virology; Disease Transmission, Infectious / prevention & control; Gene Frequency; Genes, Lethal; Genetic Engineering / methods; Genotype; Inheritance Patterns; Insect Vectors / genetics; Insect Vectors / parasitology; Insect Vectors / virology; Models, Genetic; Transgenes
topics (OpenAlex): CRISPR and Genetic Engineering; Viral Infectious Diseases and Gene Expression in Insects; Bacteriophages and microbial interactions
TL;DR: A gene-drive mechanism that can be self-limiting over time and space, and is simpler to build is proposed, which involves one gene that codes for toxicity (killer) and a second that confers immunity to the toxic effects (rescue). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Gene-drive in age-structured insect populations

Evolutionary Applications, 2(2), 143–159.

By: Y. Huang n, A. Lloyd n , M. Legros n & F. Gould n 

author keywords: assortative mating; fitness cost; genetic control; mosquito; release threshold
topics (OpenAlex): CRISPR and Genetic Engineering; Insect symbiosis and bacterial influences; Insect behavior and control techniques
TL;DR: It is found that models without age‐structure and mating details can substantially overestimate or underestimate the numbers of engineered insects that must be introduced into a wild population to achieve successful gene‐drive based on the Medea and engineered underdominance mechanisms. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

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