Wesleigh F. Edwards

Works (2)

Updated: July 5th, 2023 15:50

2009 journal article

Light-Activated Cre Recombinase as a Tool for the Spatial and Temporal Control of Gene Function in Mammalian Cells

ACS CHEMICAL BIOLOGY, 4(6), 441–445.

By: W. Edwards n, D. Young n & A. Deiters n

MeSH headings : Binding Sites; Biocatalysis / radiation effects; Cells, Cultured; Cloning, Molecular; DNA / chemistry; DNA / metabolism; Genetic Engineering / methods; Humans; Integrases / chemistry; Integrases / metabolism; Models, Molecular; Nitrobenzenes / chemistry; Nitrobenzenes / pharmacology; Recombination, Genetic / radiation effects; Time Factors; Ultraviolet Rays
TL;DR: Tight spatio-temporal control over DNA recombination is achieved by the installation of a light-responsive o-nitrobenzyl caging group directly in the catalytic site of Cre, inhibiting its activity. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 journal article

The effect of microwave irradiation on DNA hybridization

ORGANIC & BIOMOLECULAR CHEMISTRY, 7(12), 2506–2508.

By: W. Edwards n, D. Young n & A. Deiters n

MeSH headings : Base Sequence; DNA / chemistry; DNA / genetics; DNA / radiation effects; Microwaves; Nucleic Acid Denaturation / radiation effects; Nucleic Acid Hybridization / radiation effects; Spectrometry, Fluorescence; Transition Temperature
TL;DR: Observations indicate a specific interaction of microwaves with DNA, and have important implications in the chemical or enzymatic processing of DNA under microwave heating. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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