Fulton Wong

Works (3)

Updated: August 6th, 2023 21:16

2011 journal article

Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration

TRANSGENIC RESEARCH, 20(6), 1391–1395.

By: J. Sommer n, F. Wong* & R. Petters n

author keywords: Transgenic; Pig; Rhodopsin; Phenotype
MeSH headings : Age Factors; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Eosine Yellowish-(YS) / metabolism; Eye / pathology; Female; Hematoxylin / metabolism; Inbreeding; Inheritance Patterns; Male; Phenotype; Photoreceptor Cells, Vertebrate / metabolism; Photoreceptor Cells, Vertebrate / pathology; Retina / metabolism; Retina / pathology; Retinal Degeneration / pathology; Rhodopsin / genetics; Rhodopsin / metabolism; Staining and Labeling; Swine / genetics; Swine / metabolism; Transgenes
topics (OpenAlex): Retinal Development and Disorders; CRISPR and Genetic Engineering; Photoreceptor and optogenetics research
TL;DR: The phenotype, based on assessment of photoreceptor degeneration, is similar to that of the first description of the transgenic animals and can be used confidently in future studies of the type of retinal degeneration seen with retinitis pigmentosa. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 journal article

Multifocal Electroretinogram in Rhodopsin P347L Transgenic Pigs

Investigative Opthalmology & Visual Science, 49(5), 2208.

By: Y. Ng*, H. Chan *, P. Chu *, C. To *, B. Gilger* , R. Petters n, F. Wong*

MeSH headings : Aminobutyrates; Animals; Animals, Genetically Modified; Computers, Handheld; Disease Models, Animal; Electroretinography; Mutation; N-Methylaspartate / toxicity; Photoreceptor Cells, Vertebrate / physiology; Pipecolic Acids / toxicity; Retinal Bipolar Cells / physiology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / genetics; Swine; Synapses / physiology; Synaptic Transmission / drug effects; Synaptic Transmission / physiology; Tetrodotoxin / toxicity; Vision, Ocular
topics (OpenAlex): Retinal Development and Disorders; Photoreceptor and optogenetics research; Neuroscience and Neural Engineering
TL;DR: In Tg retinas, ectopic synapses formed between cones and rod bipolar cells probably altered signal processing of the ON-bipolar cell pathway and signal processing in inner retinal neurons was also modified. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Porcine global flash multifocal electroretinogram: Possible mechanisms for the glaucomatous changes in contrast response function

Vision Research, 48(16), 1726–1734.

By: P. Chu *, H. Chan *, Y. Ng*, B. Brown *, A. Siu*, B. Beale n, B. Gilger n , F. Wong*

author keywords: multifocal electroretinogram; global flash; pig; contrast; adaptation
MeSH headings : Animals; Contrast Sensitivity / physiology; Electroretinography / methods; Glaucoma / physiopathology; Glaucoma / psychology; Photic Stimulation / methods; Retina / physiopathology; Sus scrofa
topics (OpenAlex): Retinal Development and Disorders; Glaucoma and retinal disorders; Retinal Diseases and Treatments
TL;DR: It is believed that the DC of the porcine global flash mfERG is mainly composed of contributions from photoreceptors, and ON- and OFF-bipolar cells, where inner retinal activity partially shaped the DC with superimposed regular wavelets. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

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