Works (37)

Updated: April 4th, 2024 17:52

2018 journal article

High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism

Proceedings of the National Academy of Sciences, 115(21), 5420–5425.

By: J. Chung n, X. Zhang n, B. Collins n, R. Sper n, K. Gleason n, S. Simpson n, S. Koh n, J. Sommer n ...

author keywords: HMGA2; dwarfism; swine; gene editing; organ size
MeSH headings : Animals; Cryptorchidism / etiology; Cryptorchidism / pathology; Dwarfism / etiology; Dwarfism / pathology; Female; Fetal Diseases / etiology; Fetal Diseases / pathology; Genotype; HMGA2 Protein / deficiency; HMGA2 Protein / genetics; Litter Size; Male; Nuclear Transfer Techniques / veterinary; Pregnancy; Reproduction; Swine; Swine Diseases / etiology; Swine Diseases / pathology
TL;DR: The results show that the effect of HMGA2 with respect to growth regulation is highly conserved among mammals and opens up the possibility of regulating body and organ size in a variety of mammalian species including food and companion animals. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Effect of Plant Species, Fertilizer Acidity/Basicity, and Fertilizer Concentration on pH of Soilless Root Substrate

HORTSCIENCE, 51(12), 1596–1601.

By: K. Jeong, P. Nelson, C. Niedziela & D. Dickey

author keywords: alkalinity; electrical conductivity; root media
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Cloning, characterization, and expression analysis of the pig (Sus scrofa) C1q tumor necrosis factor-related protein-5 gene

Molecular Vision, 18(12-14), 92–102.

By: J. Sommer, V. Chavali, S. Simpson, R. Ayyagari & R. Petters

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Photoreceptor Differentiation following Transplantation of Allogeneic Retinal Progenitor Cells to the Dystrophic Rhodopsin Pro347Leu Transgenic Pig

STEM CELLS INTERNATIONAL, 2012.

By: H. Klassen*, J. Kiilgaard*, K. Warfvinge*, M. Samuel*, R. Prather*, F. Wong*, R. Petters n, M. Cour*, M. Young*

TL;DR: Together, these data support the tolerance of RPCs as allografts and demonstrate the high level of rod photoreceptor development that can be obtained from cultured RPCs following transplantation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Transgenic Stra8-EYFP pigs: a model for developing male germ cell technologies

TRANSGENIC RESEARCH, 21(2), 383–392.

By: J. Sommer n, L. Jackson n, S. Simpson n, E. Collins n, J. Piedrahita n & R. Petters n

author keywords: Pig; Transgenic; Stra8; Spermatogonia; Marker gene
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Blotting, Western; Cells, Cultured; Cloning, Molecular; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Regulation, Developmental; Genes, Reporter; Germ Cells / cytology; Germ Cells / metabolism; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Immunohistochemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Mice; Microscopy, Fluorescence / methods; Mitochondria / genetics; Mitochondria / metabolism; Nuclear Transfer Techniques; Plasmids / genetics; Plasmids / metabolism; Promoter Regions, Genetic; Proteins / genetics; Proteins / metabolism; Swine; Testis / cytology; Testis / metabolism; Transfection; Transgenes; Tretinoin / pharmacology
TL;DR: Transgenic pigs expressing mitochondrial localized enhanced yellow fluorescent protein (EYFP-mito) under control of the germ cell specific Stimulated by Retinoic Acid 8 (Stra8) promoter indicates that these pigs will be useful by providing labelled cells for use in such technologies such as germ cell transplantation and in vitro spermatogenic studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration

TRANSGENIC RESEARCH, 20(6), 1391–1395.

By: J. Sommer n, F. Wong* & R. Petters n

author keywords: Transgenic; Pig; Rhodopsin; Phenotype
MeSH headings : Age Factors; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Eosine Yellowish-(YS) / metabolism; Eye / pathology; Female; Hematoxylin / metabolism; Inbreeding; Inheritance Patterns; Male; Phenotype; Photoreceptor Cells, Vertebrate / metabolism; Photoreceptor Cells, Vertebrate / pathology; Retina / metabolism; Retina / pathology; Retinal Degeneration / pathology; Rhodopsin / genetics; Rhodopsin / metabolism; Staining and Labeling; Swine / genetics; Swine / metabolism; Transgenes
TL;DR: The phenotype, based on assessment of photoreceptor degeneration, is similar to that of the first description of the transgenic animals and can be used confidently in future studies of the type of retinal degeneration seen with retinitis pigmentosa. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration

British Journal of Ophthalmology, 95(12), 1749–1754.

By: J. Sommer n, J. Estrada n, E. Collins n, M. Bedell*, C. Alexander n, Z. Yang*, G. Hughes*, B. Mir n ...

MeSH headings : Animals; Animals, Genetically Modified; Disease Models, Animal; Electroretinography; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Deletion; Immunohistochemistry; Macular Degeneration / metabolism; Macular Degeneration / pathology; Macular Degeneration / physiopathology; Membrane Proteins / biosynthesis; Membrane Proteins / genetics; Microscopy, Fluorescence; Mutation; Retina / metabolism; Retina / pathology; Retina / physiopathology; Swine
TL;DR: These transgenic pigs provide unique animal models for examining macular degeneration and STGD3 pathogenesis and direct fluorescence microscopy indicated that the Y270terEYFP protein is expressed in photoreceptors and mislocalised within the cell. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Identification of a Promoter for the Human C1q-Tumor Necrosis Factor-Related Protein-5 Gene Associated with Late-Onset Retinal Degeneration

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(11), 5499–5507.

By: V. Chavali*, J. Sommer n, R. Petters n & R. Ayyagari*

MeSH headings : 3' Untranslated Regions / genetics; Animals; Base Sequence; Blotting, Western; Cell Line; Collagen / genetics; Fluorescent Antibody Technique, Indirect; Gene Amplification; Gene Expression Regulation / physiology; Humans; Membrane Proteins / genetics; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic / genetics; Retinal Degeneration / genetics; Retinal Pigment Epithelium / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transfection
TL;DR: This study revealed the presence of a functional promoter for the CTRP5 gene located 5' of its start site, and the predicted hCTRP5 promoter was found to control the expression of V5-tagged pCT RP5 and nuclear GFP, indicating that the promoter was functional. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Multifocal Electroretinogram in Rhodopsin P347L Transgenic Pigs

Investigative Opthalmology & Visual Science, 49(5), 2208.

By: Y. Ng*, H. Chan*, P. Chu*, C. To*, B. Gilger*, R. Petters n, F. Wong*

MeSH headings : Aminobutyrates; Animals; Animals, Genetically Modified; Computers, Handheld; Disease Models, Animal; Electroretinography; Mutation; N-Methylaspartate / toxicity; Photoreceptor Cells, Vertebrate / physiology; Pipecolic Acids / toxicity; Retinal Bipolar Cells / physiology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / genetics; Swine; Synapses / physiology; Synaptic Transmission / drug effects; Synaptic Transmission / physiology; Tetrodotoxin / toxicity; Vision, Ocular
TL;DR: In Tg retinas, ectopic synapses formed between cones and rod bipolar cells probably altered signal processing of the ON-bipolar cell pathway and signal processing in inner retinal neurons was also modified. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 article

Successful cloning of the Yucatan minipig using commercial/occidental breeds as oocyte donors and embryo recipients

Estrada, J. L., Collins, B., York, A., Bischoff, S., Sommer, J., Tsai, S., … Piedrahita, J. A. (2008, June). CLONING AND STEM CELLS, Vol. 10, pp. 287–296.

By: J. Estrada n, B. Collins n, A. York n, S. Bischoff n, J. Sommer n, S. Tsai n, R. Petters n, J. Piedrahita n

MeSH headings : Animals; Cell Line; Cloning, Organism / methods; Fibroblasts / cytology; Microsatellite Repeats; Nuclear Transfer Techniques; Oocytes / physiology; Sus scrofa; Swine; Swine, Miniature / embryology
TL;DR: This report shows that it is possible to produce viable Yucatan SCNT clones and opens up the possibility of developing valuable biomedical models in this porcine breed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Long-term neuroretinal full-thickness transplants in a large animal model of severe retinitis pigmentosa

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 245(6), 835–846.

By: F. Ghosh*, K. Engelsberg*, R. English n & R. Petters n

author keywords: immune privilege; photoreceptor morphology; retinal degeneration; vitreoretinal surgery
MeSH headings : Animals; Animals, Genetically Modified; Biomarkers; Dark Adaptation; Disease Models, Animal; Electroretinography; Female; Fetal Tissue Transplantation; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Glial Fibrillary Acidic Protein / metabolism; Graft Survival / physiology; Neuroglia / physiology; Pregnancy; Protein Kinase C / metabolism; Retina / metabolism; Retina / physiopathology; Retina / transplantation; Retinal Bipolar Cells / physiology; Retinal Rod Photoreceptor Cells / physiology; Retinitis Pigmentosa / metabolism; Retinitis Pigmentosa / physiopathology; Retinitis Pigmentosa / surgery; Rhodopsin / genetics; Rhodopsin / metabolism; Swine; Transducin / metabolism; Transplantation, Homologous; Vitrectomy
TL;DR: Fetal full-thickness neuroretina can be transplanted safely to an eye with severe retinal degeneration, and in their major part, the transplants develop a normal laminated morphology and survive for at least 6 months. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Swine generated by somatic cell nuclear transfer have increased incidence of intrauterine growth restriction (IUGR)

CLONING AND STEM CELLS, 9(2), 229–236.

By: J. Estrada n, J. Sommer n, B. Collins n, B. Mir n, A. Martin n, A. York n, R. Petters n, J. Piedrahita n

MeSH headings : Animals; Birth Weight / physiology; Fetal Growth Retardation; Insemination, Artificial; Litter Size / physiology; Nuclear Transfer Techniques; Swine
TL;DR: SCNT-derived pigs are excellent models to study epigenetic factors and genes involved in IUGRs, and to develop effective means to improve fetal growth in humans and animals, and there are some differences between SCNT- derived and AI litters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Synchronization and superovulation of mature cycling gilts for the collection of pronuclear stage embryos

ANIMAL REPRODUCTION SCIENCE, 100(3-4), 402–410.

By: J. Sommer n, E. Collins n, J. Estrada n & R. Petters n

author keywords: gilt; superovulation; estrous synchronization; pronuclear stage embryo; PG600 (R); prostaglandin F-2 alpha; transgenic
MeSH headings : Animals; Chorionic Gonadotropin / pharmacology; Dinoprost / analogs & derivatives; Dinoprost / pharmacology; Embryo, Mammalian; Estrous Cycle; Estrus Synchronization / methods; Female; Superovulation / drug effects; Superovulation / physiology; Swine / physiology
TL;DR: An efficient protocol to synchronize and superovulate mature pigs for the collection of pronuclear stage embryos suitable for DNA microinjection and Pigs 10-16 days after the beginning of standing estrus have been successfully synchronized into estrus using this protocol. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Reporter system for the detection of in vivo gene conversion - Changing colors from blue to green using GFP variants

MOLECULAR BIOTECHNOLOGY, 33(2), 115–121.

By: J. Sommer n, O. Aiderson, G. Laible* & R. Petters n

author keywords: gene conversion; marker; GFP; BFP; oligonucleotide; phosphorothioated; transfection
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Clone Cells; Color; Cricetinae; Cricetulus; Gene Conversion / genetics; Genes, Reporter; Genetic Techniques; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Luminescent Proteins / chemistry; Luminescent Proteins / genetics; Molecular Sequence Data; Mutation / genetics; Oligonucleotides / genetics; Plasmids / genetics; Transfection
TL;DR: A thio-protected single-stranded oligonucleotide designed to convert the genotype of the blue variant to that of the EGFP variant by the correction of a single base pair was delivered to the reported cells using a variety of methodologies and strategies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin

Molecular Vision, 11(142), 1246–1256.

By: T. Kraft, D. Allen, R. Petters, Y. Hao, Y. Peng & F. Wong

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Conditional induction of ovulation in mice

BIOLOGY OF REPRODUCTION, 73(4), 681–687.

By: P. Su n, J. Wu n, . Sommer n, A. Gore n, R. Petters n & W. Miller n

author keywords: assisted reproductive technology; anterior pituitary; follicle-stimulating hormone; gene regulation; ovulation
MeSH headings : Animals; Cells, Cultured; Doxycycline / pharmacology; Female; Follicle Stimulating Hormone / blood; Follicle Stimulating Hormone / genetics; Follicle Stimulating Hormone, beta Subunit / genetics; Follicle Stimulating Hormone, beta Subunit / metabolism; Genetic Engineering / methods; Male; Mice; Mice, Transgenic; Ovary / drug effects; Ovary / physiology; Ovulation / drug effects; Ovulation / genetics; Ovulation / physiology; Ovulation Induction / methods; Superovulation / genetics
TL;DR: In summary, gene switch technology and normal FSH regulation were combined to effectively enhance ovulation in mice and the same strategy can be used with any genetic switch to increase ovulation (or any highly conserved physiology) in any mammal. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa

JOURNAL OF CELLULAR PHYSIOLOGY, 203(3), 457–464.

By: J. Shen*, X. Yang*, A. Dong*, R. Petters n, Y. Peng*, F. Wong*, P. Campochiaro*

MeSH headings : Acrolein / metabolism; Aldehydes / metabolism; Animals; Animals, Genetically Modified; Biomarkers / metabolism; Cell Communication / physiology; Cell Death / physiology; Cell Survival / physiology; DNA Damage / physiology; Disease Models, Animal; Hyperoxia / genetics; Hyperoxia / metabolism; Hyperoxia / physiopathology; Immunohistochemistry; Lipid Peroxidation / physiology; Nerve Degeneration / genetics; Nerve Degeneration / metabolism; Nerve Degeneration / physiopathology; Oxidative Stress / physiology; Retinal Cone Photoreceptor Cells / metabolism; Retinal Cone Photoreceptor Cells / pathology; Retinal Rod Photoreceptor Cells / metabolism; Retinal Rod Photoreceptor Cells / pathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / metabolism; Retinitis Pigmentosa / physiopathology; Sus scrofa
TL;DR: The hypothesis that cones die from oxidative damage by performing immunohistochemical staining for biomarkers of oxidative damage in a transgenic pig model of RP supports the hypothesis that the death of rods results in decreased oxygen consumption and hyperoxia in the outer retina resulting in gradual cone cell death from oxidativeDamage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 article

Transplantation of full-thickness retina in the rhodopsin transgenic pig

Ghosh, F., Wong, F., Johansson, K., Bruun, A., & Peters, R. M. (2004, February). RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, Vol. 24, pp. 98–109.

By: F. Ghosh, F. Wong, K. Johansson, A. Bruun & R. Peters

MeSH headings : Animals; Animals, Genetically Modified; Animals, Newborn; Calcium-Binding Proteins / metabolism; Cell Polarity; Eye Proteins; Fluorescent Antibody Technique, Indirect; Graft Survival; Hippocalcin; Lipoproteins; Nerve Tissue Proteins; Neuroglia / metabolism; Neuroglia / pathology; Photoreceptor Cells, Vertebrate / metabolism; Photoreceptor Cells, Vertebrate / pathology; Pigment Epithelium of Eye / metabolism; Pigment Epithelium of Eye / pathology; Protein Kinase C / metabolism; Recoverin; Retina / metabolism; Retina / pathology; Retina / transplantation; Retinal Degeneration / genetics; Retinal Degeneration / metabolism; Retinal Degeneration / pathology; Retinal Degeneration / surgery; Rhodopsin / genetics; Swine / genetics; Vimentin / metabolism
TL;DR: Full-thickness neuroretinal grafts can be transplanted to a large animal host with photoreceptor degeneration and survive well for at least 4 months, according to the transplantation procedure and eye specimens studied. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 241(4), 298–308.

By: T. Mahmoud*, B. McCuen*, Y. Hao*, S. Moon*, M. Tatebayashi*, S. Stinnett*, R. Petters n, F. Wong*

MeSH headings : Animals; Animals, Genetically Modified; Cell Count; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Lens, Crystalline / surgery; Photoreceptor Cells, Vertebrate / metabolism; Photoreceptor Cells, Vertebrate / pathology; Retinal Degeneration / genetics; Retinal Degeneration / pathology; Retinal Degeneration / prevention & control; Rhodopsin / genetics; Rhodopsin / metabolism; Vitrectomy
TL;DR: Lensectomy and vitrectomy delay photoreceptor degeneration in rhodopsin P347L transgenic pigs, and lens-related rescue effect is a probable reason for the delayed degeneration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Conservation and regeneration of transgenic lines of swine by semen cryopreservation and artificial insemination

Lab Animal, 31(1), 25–31.

By: J. Sommer, E. Collins, T. Neiding, K. Rozeboom, F. Wong & R. Petters

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Roles of gene transcription and PKA subtype activation in maturation of murine oocytes

Reproduction (Cambridge, England), 123(6), 799–806.

By: K. Rodriguez n, R. Petters*, A. Crosier* & C. Farin*

MeSH headings : Amanitins / pharmacology; Animals; Cells, Cultured; Chorionic Gonadotropin / pharmacology; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / metabolism; Dichlororibofuranosylbenzimidazole / pharmacology; Enzyme Activation / physiology; Enzyme Inhibitors / pharmacology; Female; Follicle Stimulating Hormone / pharmacology; Isoenzymes / metabolism; Mice; Mice, Inbred Strains; Oogenesis / physiology; Transcription, Genetic / drug effects; Transcription, Genetic / physiology
TL;DR: Results indicate that, in cultured murine COCs, FSH binding to cumulus cells results in the activation of type II PKA, which, in turn, mediates a downstream transcriptional event required for the initiation of GVBD. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

An allele-specific hammerhead ribozyme gene therapy for a porcine model of autosomal dominant retinitis pigmentosa

Molecular Vision, 7(2), 6–13.

By: L. Shaw, A. Skold, F. Wong, R. Petters, W. Hauswirth & A. Lewin

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Early loss of synaptic protein PSD-95 from rod terminals of rhodopsin P347L transgenic porcine retina

BRAIN RESEARCH, 885(1), 53–61.

By: S. Blackmon*, Y. Peng*, Y. Hao*, S. Moon*, L. Oliveira*, M. Tatebayashi*, R. Petters n, F. Wong*

author keywords: PSD-95; retinal degeneration; retinitis pigmentosa
MeSH headings : Animals; Animals, Genetically Modified; Animals, Newborn; Antibodies; Disease Models, Animal; Nerve Tissue Proteins / analysis; Nerve Tissue Proteins / immunology; Nerve Tissue Proteins / metabolism; Retinal Rod Photoreceptor Cells / chemistry; Retinal Rod Photoreceptor Cells / metabolism; Retinal Rod Photoreceptor Cells / pathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / metabolism; Retinitis Pigmentosa / pathology; Rhodopsin / genetics; Swine; Synapses / chemistry; Synapses / metabolism
TL;DR: The results suggest that loss of PSD-95 may not be a general consequence of the deteriorating cell, but may be causally related to the absence of rod-rod bipolar cell synapses in the rhodopsin P347L transgenic retina. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations

NATURE NEUROSCIENCE, 3(11), 1121–1127.

By: Y. Peng*, Y. Hao*, R. Petters n & F. Wong*

MeSH headings : 3',5'-Cyclic-GMP Phosphodiesterases / genetics; 3',5'-Cyclic-GMP Phosphodiesterases / metabolism; Animals; Animals, Genetically Modified; Cyclic Nucleotide Phosphodiesterases, Type 6; GTP-Binding Proteins / metabolism; Mice; Mutation / physiology; Nerve Degeneration / genetics; Nerve Degeneration / metabolism; Neuronal Plasticity / physiology; Phosphoric Diester Hydrolases; Retina / physiology; Retinal Cone Photoreceptor Cells / cytology; Retinal Cone Photoreceptor Cells / physiology; Retinal Rod Photoreceptor Cells / cytology; Retinal Rod Photoreceptor Cells / physiology; Rhodopsin / genetics; Rhodopsin / metabolism; Swine; Synapses / physiology
TL;DR: In animals with rod and cone degeneration due to mutations in the genes encoding rhodopsin and cGMP phosphodiesterase β-subunit respectively, it is shown that rod bipolar cells received ectopic synapses from cones in the absence of rods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 personal communication

Optical coherence tomography (OCT) abnormalities in rhodopsin mutant transgenic swine with retinal degeneration

Huang, Y. J., Cideciyan, A. V., Aleman, T. S., Banin, E., Huang, J. C., Syed, N. A., … Jacobson, S. G. (2000, February).

MeSH headings : Animals; Animals, Genetically Modified; Mutation / genetics; Retinal Degeneration / genetics; Rhodopsin / genetics; Swine; Tomography
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Transgenic animals as models for human disease

TRANSGENIC RESEARCH, 9(4-5), 347–351.

By: R. Petters n & . Sommer n

author keywords: transgenic animals; models of disease; homologous recombination
MeSH headings : Animals; Animals, Genetically Modified / genetics; Disease Models, Animal; Genetic Techniques; Genetic Vectors; Humans
TL;DR: The current level and complexity of inquiry using transgenic animals is documented to study the pathological mechanisms behind the disease rather than to just provide a model of the disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Gonadotropin-induced germinal vesicle breakdown in the mouse requires gene transcription.

Biology of Reproduction, 60(1999), 214.

By: K. Rodriguez, R. Petters & C. Farin

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development

NEURON, 23(3), 549–557.

By: E. Banin*, A. Cideciyan*, T. Aleman*, R. Petters n, F. Wong*, A. Milam*, S. Jacobson*

MeSH headings : Amino Acid Substitution; Animals; Animals, Genetically Modified; Dark Adaptation / physiology; Electroretinography; Gene Expression Regulation, Developmental; Humans; Membrane Potentials / physiology; Neural Pathways; Retinal Cone Photoreceptor Cells / growth & development; Retinal Cone Photoreceptor Cells / physiology; Retinal Rod Photoreceptor Cells / growth & development; Retinal Rod Photoreceptor Cells / physiology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / genetics; Swine; Synapses / physiology
TL;DR: Recordings throughout postnatal development indicated a failure of cone circuitry maturation, a novel mechanism of secondary cone abnormality in rod dystrophy, and the possibility that rod afferent activity plays a role in the postnatal maturation of cone retinal circuitry is raised. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Developmental competence of immature pig oocytes under the influence of EGF, IGF-I, follicular fluid and gonadotropins during IVM-IVF processes

International Journal of Developmental Biology, 42(8), 1169–1172.

By: M. Illera, P. Lorenzo, J. Illera & R. Petters

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Rhodopsin transgenic pigs as a model for human retinitis pigmentosa

Investigative Ophthalmology and Visual Science, 39(5), 808–819.

By: Z. Li, F. Wong, J. Chang, D. Possin, Y. Hao, R. Petters, A. Milam

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa

NATURE BIOTECHNOLOGY, 15(10), 965–970.

By: R. Petters n, C. Alexander n, K. Wells n, E. Collins n, . Sommer n, M. Blanton n, G. Rojas n, Y. Hao* ...

author keywords: transgenic swine; retinal degeneration; rhodopsin mutation; night blindness; eye disease
MeSH headings : Animals; Animals, Genetically Modified; Blotting, Southern; Disease Models, Animal; Electroretinography; Embryo Transfer; Gene Expression Regulation / genetics; Genetic Engineering; Microscopy, Electron; Molecular Sequence Data; Phenotype; Polymerase Chain Reaction; Retina / pathology; Retina / physiopathology; Retina / ultrastructure; Retinal Cone Photoreceptor Cells / physiopathology; Retinal Cone Photoreceptor Cells / ultrastructure; Retinal Degeneration / physiopathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / chemistry; Rhodopsin / genetics; Swine / embryology; Swine / genetics; Transgenes
TL;DR: These transgenic pigs that express a mutated rhodopsin gene will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1994 article

TRANSGENIC LIVESTOCK AS GENETIC MODELS OF HUMAN-DISEASE

REPRODUCTION FERTILITY AND DEVELOPMENT, Vol. 6, pp. 643–645.

By: R. Petters*

MeSH headings : Acromegaly / genetics; Animals; Animals, Genetically Modified / genetics; Eye Diseases / genetics; Genetic Diseases, Inborn / genetics; Humans; Models, Genetic; Swine
TL;DR: In the future, livestock will play an increasingly more important role in biomedical research through the application of genetic engineering methodologies and will allow for increased sophistication of experimental design and wider use of genetically modified livestock. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1992 article

EMBRYO DEVELOPMENT INVITRO TO THE BLASTOCYST STAGE IN CATTLE, PIGS AND SHEEP

PETTERS, R. M. (1992, July). ANIMAL REPRODUCTION SCIENCE, Vol. 28, pp. 415–421.

By: R. Petters n

TL;DR: Success of embryo culture is high enough to warrant considerable optimism about further improvements in the efficiency of many embryo technologies, including nuclear transfer (cloning) and gene transfer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1990 journal article

Glucose, glutamine and inorganic phosphate in early development of the pig embryo in vitro

Journal of Reproduction & Fertility, 89(1), 269.

By: R. Petters n, B. Johnson n, M. Reed n & A. Archibong n

MeSH headings : Animals; Blastocyst / metabolism; Culture Media; Culture Techniques / methods; Embryonic and Fetal Development / physiology; Glucose / metabolism; Glutamine / metabolism; Phosphates / metabolism; Swine / physiology
TL;DR: The greatest development was achieved with glucose and glutamine (both alone and in combination) in the media, demonstrating that an amino acid can serve as the sole energy source for complete preimplantation embryonic development in vitro. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1986 journal article

Recombinant DNA, gene transfer and the future of animal agriculture

Journal of Animal Science, 62(6), 1759.

By: R. Petters

Source: NC State University Libraries
Added: August 6, 2018

1978 journal article

FLIGHTLESS MUTATION IN WASP HABROBRACON-JUGLANDIS

JOURNAL OF HEREDITY, 69(2), 113–116.

By: R. Petters*, D. Grosch & C. Olson

Source: Web Of Science
Added: August 6, 2018

1977 journal article

REPRODUCTIVE-PERFORMANCE OF BRACON-HEBETOR (HYMENOPTERA-BRACONIDAE) FEMALES WITH MORE OR FEWER THAN NORMAL NUMBER OF OVARIOLES

ANNALS OF THE ENTOMOLOGICAL SOCIETY OF AMERICA, 70(4), 577–582.

By: R. Petters n & D. Grosch n

TL;DR: Wasps with fewer than 4 ovarioles produced proportionately fewer eggs than their “normal” 4-ovariole sisters, and in females with 5–9 ovariolaes, egg production did not increase significantly, suggesting the supply of vitellogenic materials is a limiting factor. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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