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Works (37)
Updated: August 16th, 2024 13:38
2018 journal article
High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism
Proceedings of the National Academy of Sciences, 115(21), 5420–5425.
author keywords: HMGA2; dwarfism; swine; gene editing; organ size
MeSH headings : Animals; Cryptorchidism / etiology; Cryptorchidism / pathology; Dwarfism / etiology; Dwarfism / pathology; Female; Fetal Diseases / etiology; Fetal Diseases / pathology; Genotype; HMGA2 Protein / deficiency; HMGA2 Protein / genetics; Litter Size; Male; Nuclear Transfer Techniques / veterinary; Pregnancy; Reproduction; Swine; Swine Diseases / etiology; Swine Diseases / pathology
TL;DR:
The results show that the effect of HMGA2 with respect to growth regulation is highly conserved among mammals and opens up the possibility of regulating body and organ size in a variety of mammalian species including food and companion animals.
(via Semantic Scholar)
open access via www.pnas.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Effect of Plant Species, Fertilizer Acidity/Basicity, and Fertilizer Concentration on pH of Soilless Root Substrate
HORTSCIENCE, 51(12), 1596–1601.
author keywords: alkalinity; electrical conductivity; root media
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Cloning, characterization, and expression analysis of the pig (Sus scrofa) C1q tumor necrosis factor-related protein-5 gene
Molecular Vision, 18(12-14), 92–102.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Photoreceptor Differentiation following Transplantation of Allogeneic Retinal Progenitor Cells to the Dystrophic Rhodopsin Pro347Leu Transgenic Pig
STEM CELLS INTERNATIONAL, 2012.
TL;DR:
Together, these data support the tolerance of RPCs as allografts and demonstrate the high level of rod photoreceptor development that can be obtained from cultured RPCs following transplantation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration
TRANSGENIC RESEARCH, 20(6), 1391–1395.
author keywords: Transgenic; Pig; Rhodopsin; Phenotype
MeSH headings : Age Factors; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Eosine Yellowish-(YS) / metabolism; Eye / pathology; Female; Hematoxylin / metabolism; Inbreeding; Inheritance Patterns; Male; Phenotype; Photoreceptor Cells, Vertebrate / metabolism; Photoreceptor Cells, Vertebrate / pathology; Retina / metabolism; Retina / pathology; Retinal Degeneration / pathology; Rhodopsin / genetics; Rhodopsin / metabolism; Staining and Labeling; Swine / genetics; Swine / metabolism; Transgenes
TL;DR:
The phenotype, based on assessment of photoreceptor degeneration, is similar to that of the first description of the transgenic animals and can be used confidently in future studies of the type of retinal degeneration seen with retinitis pigmentosa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration
British Journal of Ophthalmology, 95(12), 1749–1754.
MeSH headings : Animals; Animals, Genetically Modified; Disease Models, Animal; Electroretinography; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Deletion; Immunohistochemistry; Macular Degeneration / metabolism; Macular Degeneration / pathology; Macular Degeneration / physiopathology; Membrane Proteins / biosynthesis; Membrane Proteins / genetics; Microscopy, Fluorescence; Mutation; Retina / metabolism; Retina / pathology; Retina / physiopathology; Swine
TL;DR:
These transgenic pigs provide unique animal models for examining macular degeneration and STGD3 pathogenesis and direct fluorescence microscopy indicated that the Y270terEYFP protein is expressed in photoreceptors and mislocalised within the cell.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2011 journal article
Transgenic Stra8-EYFP pigs: a model for developing male germ cell technologies
TRANSGENIC RESEARCH, 21(2), 383–392.
author keywords: Pig; Transgenic; Stra8; Spermatogonia; Marker gene
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Blotting, Western; Cells, Cultured; Cloning, Molecular; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Regulation, Developmental; Genes, Reporter; Germ Cells / cytology; Germ Cells / metabolism; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Immunohistochemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Mice; Microscopy, Fluorescence / methods; Mitochondria / genetics; Mitochondria / metabolism; Nuclear Transfer Techniques; Plasmids / genetics; Plasmids / metabolism; Promoter Regions, Genetic; Proteins / genetics; Proteins / metabolism; Swine; Testis / cytology; Testis / metabolism; Transfection; Transgenes; Tretinoin / pharmacology
TL;DR:
Transgenic pigs expressing mitochondrial localized enhanced yellow fluorescent protein (EYFP-mito) under control of the germ cell specific Stimulated by Retinoic Acid 8 (Stra8) promoter indicates that these pigs will be useful by providing labelled cells for use in such technologies such as germ cell transplantation and in vitro spermatogenic studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Identification of a Promoter for the Human C1q-Tumor Necrosis Factor-Related Protein-5 Gene Associated with Late-Onset Retinal Degeneration
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(11), 5499–5507.
MeSH headings : 3' Untranslated Regions / genetics; Animals; Base Sequence; Blotting, Western; Cell Line; Collagen / genetics; Fluorescent Antibody Technique, Indirect; Gene Amplification; Gene Expression Regulation / physiology; Humans; Membrane Proteins / genetics; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic / genetics; Retinal Degeneration / genetics; Retinal Pigment Epithelium / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transfection
TL;DR:
This study revealed the presence of a functional promoter for the CTRP5 gene located 5' of its start site, and the predicted hCTRP5 promoter was found to control the expression of V5-tagged pCT RP5 and nuclear GFP, indicating that the promoter was functional.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Multifocal Electroretinogram in Rhodopsin P347L Transgenic Pigs
Investigative Opthalmology & Visual Science, 49(5), 2208.
MeSH headings : Aminobutyrates; Animals; Animals, Genetically Modified; Computers, Handheld; Disease Models, Animal; Electroretinography; Mutation; N-Methylaspartate / toxicity; Photoreceptor Cells, Vertebrate / physiology; Pipecolic Acids / toxicity; Retinal Bipolar Cells / physiology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / genetics; Swine; Synapses / physiology; Synaptic Transmission / drug effects; Synaptic Transmission / physiology; Tetrodotoxin / toxicity; Vision, Ocular
TL;DR:
In Tg retinas, ectopic synapses formed between cones and rod bipolar cells probably altered signal processing of the ON-bipolar cell pathway and signal processing in inner retinal neurons was also modified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 article
Successful cloning of the Yucatan minipig using commercial/occidental breeds as oocyte donors and embryo recipients
Estrada, J. L., Collins, B., York, A., Bischoff, S., Sommer, J., Tsai, S., … Piedrahita, J. A. (2008, June). CLONING AND STEM CELLS, Vol. 10, pp. 287–296.
MeSH headings : Animals; Cell Line; Cloning, Organism / methods; Fibroblasts / cytology; Microsatellite Repeats; Nuclear Transfer Techniques; Oocytes / physiology; Sus scrofa; Swine; Swine, Miniature / embryology
TL;DR:
This report shows that it is possible to produce viable Yucatan SCNT clones and opens up the possibility of developing valuable biomedical models in this porcine breed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Swine generated by somatic cell nuclear transfer have increased incidence of intrauterine growth restriction (IUGR)
CLONING AND STEM CELLS, 9(2), 229–236.
MeSH headings : Animals; Birth Weight / physiology; Fetal Growth Retardation; Insemination, Artificial; Litter Size / physiology; Nuclear Transfer Techniques; Swine
TL;DR:
SCNT-derived pigs are excellent models to study epigenetic factors and genes involved in IUGRs, and to develop effective means to improve fetal growth in humans and animals, and there are some differences between SCNT- derived and AI litters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Long-term neuroretinal full-thickness transplants in a large animal model of severe retinitis pigmentosa
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 245(6), 835–846.
author keywords: immune privilege; photoreceptor morphology; retinal degeneration; vitreoretinal surgery
MeSH headings : Animals; Animals, Genetically Modified; Biomarkers; Dark Adaptation; Disease Models, Animal; Electroretinography; Female; Fetal Tissue Transplantation; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Glial Fibrillary Acidic Protein / metabolism; Graft Survival / physiology; Neuroglia / physiology; Pregnancy; Protein Kinase C / metabolism; Retina / metabolism; Retina / physiopathology; Retina / transplantation; Retinal Bipolar Cells / physiology; Retinal Rod Photoreceptor Cells / physiology; Retinitis Pigmentosa / metabolism; Retinitis Pigmentosa / physiopathology; Retinitis Pigmentosa / surgery; Rhodopsin / genetics; Rhodopsin / metabolism; Swine; Transducin / metabolism; Transplantation, Homologous; Vitrectomy
TL;DR:
Fetal full-thickness neuroretina can be transplanted safely to an eye with severe retinal degeneration, and in their major part, the transplants develop a normal laminated morphology and survive for at least 6 months.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Reporter system for the detection of in vivo gene conversion - Changing colors from blue to green using GFP variants
MOLECULAR BIOTECHNOLOGY, 33(2), 115–121.
author keywords: gene conversion; marker; GFP; BFP; oligonucleotide; phosphorothioated; transfection
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Clone Cells; Color; Cricetinae; Cricetulus; Gene Conversion / genetics; Genes, Reporter; Genetic Techniques; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Luminescent Proteins / chemistry; Luminescent Proteins / genetics; Molecular Sequence Data; Mutation / genetics; Oligonucleotides / genetics; Plasmids / genetics; Transfection
TL;DR:
A thio-protected single-stranded oligonucleotide designed to convert the genotype of the blue variant to that of the EGFP variant by the correction of a single base pair was delivered to the reported cells using a variety of methodologies and strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Synchronization and superovulation of mature cycling gilts for the collection of pronuclear stage embryos
ANIMAL REPRODUCTION SCIENCE, 100(3-4), 402–410.
author keywords: gilt; superovulation; estrous synchronization; pronuclear stage embryo; PG600 (R); prostaglandin F-2 alpha; transgenic
MeSH headings : Animals; Chorionic Gonadotropin / pharmacology; Dinoprost / analogs & derivatives; Dinoprost / pharmacology; Embryo, Mammalian; Estrous Cycle; Estrus Synchronization / methods; Female; Superovulation / drug effects; Superovulation / physiology; Swine / physiology
TL;DR:
An efficient protocol to synchronize and superovulate mature pigs for the collection of pronuclear stage embryos suitable for DNA microinjection and Pigs 10-16 days after the beginning of standing estrus have been successfully synchronized into estrus using this protocol.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin
Molecular Vision, 11(142), 1246–1256.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Conditional induction of ovulation in mice
BIOLOGY OF REPRODUCTION, 73(4), 681–687.
author keywords: assisted reproductive technology; anterior pituitary; follicle-stimulating hormone; gene regulation; ovulation
MeSH headings : Animals; Cells, Cultured; Doxycycline / pharmacology; Female; Follicle Stimulating Hormone / blood; Follicle Stimulating Hormone / genetics; Follicle Stimulating Hormone, beta Subunit / genetics; Follicle Stimulating Hormone, beta Subunit / metabolism; Genetic Engineering / methods; Male; Mice; Mice, Transgenic; Ovary / drug effects; Ovary / physiology; Ovulation / drug effects; Ovulation / genetics; Ovulation / physiology; Ovulation Induction / methods; Superovulation / genetics
TL;DR:
In summary, gene switch technology and normal FSH regulation were combined to effectively enhance ovulation in mice and the same strategy can be used with any genetic switch to increase ovulation (or any highly conserved physiology) in any mammal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa
JOURNAL OF CELLULAR PHYSIOLOGY, 203(3), 457–464.
MeSH headings : Acrolein / metabolism; Aldehydes / metabolism; Animals; Animals, Genetically Modified; Biomarkers / metabolism; Cell Communication / physiology; Cell Death / physiology; Cell Survival / physiology; DNA Damage / physiology; Disease Models, Animal; Hyperoxia / genetics; Hyperoxia / metabolism; Hyperoxia / physiopathology; Immunohistochemistry; Lipid Peroxidation / physiology; Nerve Degeneration / genetics; Nerve Degeneration / metabolism; Nerve Degeneration / physiopathology; Oxidative Stress / physiology; Retinal Cone Photoreceptor Cells / metabolism; Retinal Cone Photoreceptor Cells / pathology; Retinal Rod Photoreceptor Cells / metabolism; Retinal Rod Photoreceptor Cells / pathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / metabolism; Retinitis Pigmentosa / physiopathology; Sus scrofa
TL;DR:
The hypothesis that cones die from oxidative damage by performing immunohistochemical staining for biomarkers of oxidative damage in a transgenic pig model of RP supports the hypothesis that the death of rods results in decreased oxygen consumption and hyperoxia in the outer retina resulting in gradual cone cell death from oxidativeDamage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 article
Transplantation of full-thickness retina in the rhodopsin transgenic pig
Ghosh, F., Wong, F., Johansson, K., Bruun, A., & Peters, R. M. (2004, February). RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, Vol. 24, pp. 98–109.
MeSH headings : Animals; Animals, Genetically Modified; Animals, Newborn; Calcium-Binding Proteins / metabolism; Cell Polarity; Eye Proteins; Fluorescent Antibody Technique, Indirect; Graft Survival; Hippocalcin; Lipoproteins; Nerve Tissue Proteins; Neuroglia / metabolism; Neuroglia / pathology; Photoreceptor Cells, Vertebrate / metabolism; Photoreceptor Cells, Vertebrate / pathology; Pigment Epithelium of Eye / metabolism; Pigment Epithelium of Eye / pathology; Protein Kinase C / metabolism; Recoverin; Retina / metabolism; Retina / pathology; Retina / transplantation; Retinal Degeneration / genetics; Retinal Degeneration / metabolism; Retinal Degeneration / pathology; Retinal Degeneration / surgery; Rhodopsin / genetics; Swine / genetics; Vimentin / metabolism
TL;DR:
Full-thickness neuroretinal grafts can be transplanted to a large animal host with photoreceptor degeneration and survive well for at least 4 months, according to the transplantation procedure and eye specimens studied.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 241(4), 298–308.
MeSH headings : Animals; Animals, Genetically Modified; Cell Count; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Lens, Crystalline / surgery; Photoreceptor Cells, Vertebrate / metabolism; Photoreceptor Cells, Vertebrate / pathology; Retinal Degeneration / genetics; Retinal Degeneration / pathology; Retinal Degeneration / prevention & control; Rhodopsin / genetics; Rhodopsin / metabolism; Vitrectomy
TL;DR:
Lensectomy and vitrectomy delay photoreceptor degeneration in rhodopsin P347L transgenic pigs, and lens-related rescue effect is a probable reason for the delayed degeneration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Conservation and regeneration of transgenic lines of swine by semen cryopreservation and artificial insemination
Lab Animal, 31(1), 25–31.
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Roles of gene transcription and PKA subtype activation in maturation of murine oocytes
Reproduction (Cambridge, England), 123(6), 799–806.
MeSH headings : Amanitins / pharmacology; Animals; Cells, Cultured; Chorionic Gonadotropin / pharmacology; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / metabolism; Dichlororibofuranosylbenzimidazole / pharmacology; Enzyme Activation / physiology; Enzyme Inhibitors / pharmacology; Female; Follicle Stimulating Hormone / pharmacology; Isoenzymes / metabolism; Mice; Mice, Inbred Strains; Oogenesis / physiology; Transcription, Genetic / drug effects; Transcription, Genetic / physiology
TL;DR:
Results indicate that, in cultured murine COCs, FSH binding to cumulus cells results in the activation of type II PKA, which, in turn, mediates a downstream transcriptional event required for the initiation of GVBD.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
An allele-specific hammerhead ribozyme gene therapy for a porcine model of autosomal dominant retinitis pigmentosa
Molecular Vision, 7(2), 6–13.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Early loss of synaptic protein PSD-95 from rod terminals of rhodopsin P347L transgenic porcine retina
BRAIN RESEARCH, 885(1), 53–61.
author keywords: PSD-95; retinal degeneration; retinitis pigmentosa
MeSH headings : Animals; Animals, Genetically Modified; Animals, Newborn; Antibodies; Disease Models, Animal; Nerve Tissue Proteins / analysis; Nerve Tissue Proteins / immunology; Nerve Tissue Proteins / metabolism; Retinal Rod Photoreceptor Cells / chemistry; Retinal Rod Photoreceptor Cells / metabolism; Retinal Rod Photoreceptor Cells / pathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / metabolism; Retinitis Pigmentosa / pathology; Rhodopsin / genetics; Swine; Synapses / chemistry; Synapses / metabolism
TL;DR:
The results suggest that loss of PSD-95 may not be a general consequence of the deteriorating cell, but may be causally related to the absence of rod-rod bipolar cell synapses in the rhodopsin P347L transgenic retina.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations
NATURE NEUROSCIENCE, 3(11), 1121–1127.
MeSH headings : 3',5'-Cyclic-GMP Phosphodiesterases / genetics; 3',5'-Cyclic-GMP Phosphodiesterases / metabolism; Animals; Animals, Genetically Modified; Cyclic Nucleotide Phosphodiesterases, Type 6; GTP-Binding Proteins / metabolism; Mice; Mutation / physiology; Nerve Degeneration / genetics; Nerve Degeneration / metabolism; Neuronal Plasticity / physiology; Phosphoric Diester Hydrolases; Retina / physiology; Retinal Cone Photoreceptor Cells / cytology; Retinal Cone Photoreceptor Cells / physiology; Retinal Rod Photoreceptor Cells / cytology; Retinal Rod Photoreceptor Cells / physiology; Rhodopsin / genetics; Rhodopsin / metabolism; Swine; Synapses / physiology
TL;DR:
In animals with rod and cone degeneration due to mutations in the genes encoding rhodopsin and cGMP phosphodiesterase β-subunit respectively, it is shown that rod bipolar cells received ectopic synapses from cones in the absence of rods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 personal communication
Optical coherence tomography (OCT) abnormalities in rhodopsin mutant transgenic swine with retinal degeneration
Huang, Y. J., Cideciyan, A. V., Aleman, T. S., Banin, E., Huang, J. C., Syed, N. A., … Jacobson, S. G. (2000, February).
MeSH headings : Animals; Animals, Genetically Modified; Mutation / genetics; Retinal Degeneration / genetics; Rhodopsin / genetics; Swine; Tomography
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Transgenic animals as models for human disease
TRANSGENIC RESEARCH, 9(4-5), 347–351.
author keywords: transgenic animals; models of disease; homologous recombination
MeSH headings : Animals; Animals, Genetically Modified / genetics; Disease Models, Animal; Genetic Techniques; Genetic Vectors; Humans
TL;DR:
The current level and complexity of inquiry using transgenic animals is documented to study the pathological mechanisms behind the disease rather than to just provide a model of the disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Gonadotropin-induced germinal vesicle breakdown in the mouse requires gene transcription.
Biology of Reproduction, 60(1999), 214.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development
NEURON, 23(3), 549–557.
MeSH headings : Amino Acid Substitution; Animals; Animals, Genetically Modified; Dark Adaptation / physiology; Electroretinography; Gene Expression Regulation, Developmental; Humans; Membrane Potentials / physiology; Neural Pathways; Retinal Cone Photoreceptor Cells / growth & development; Retinal Cone Photoreceptor Cells / physiology; Retinal Rod Photoreceptor Cells / growth & development; Retinal Rod Photoreceptor Cells / physiology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / genetics; Swine; Synapses / physiology
TL;DR:
Recordings throughout postnatal development indicated a failure of cone circuitry maturation, a novel mechanism of secondary cone abnormality in rod dystrophy, and the possibility that rod afferent activity plays a role in the postnatal maturation of cone retinal circuitry is raised.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Developmental competence of immature pig oocytes under the influence of EGF, IGF-I, follicular fluid and gonadotropins during IVM-IVF processes
International Journal of Developmental Biology, 42(8), 1169–1172.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Rhodopsin transgenic pigs as a model for human retinitis pigmentosa
Investigative Ophthalmology and Visual Science, 39(5), 808–819.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa
NATURE BIOTECHNOLOGY, 15(10), 965–970.
author keywords: transgenic swine; retinal degeneration; rhodopsin mutation; night blindness; eye disease
MeSH headings : Animals; Animals, Genetically Modified; Blotting, Southern; Disease Models, Animal; Electroretinography; Embryo Transfer; Gene Expression Regulation / genetics; Genetic Engineering; Microscopy, Electron; Molecular Sequence Data; Phenotype; Polymerase Chain Reaction; Retina / pathology; Retina / physiopathology; Retina / ultrastructure; Retinal Cone Photoreceptor Cells / physiopathology; Retinal Cone Photoreceptor Cells / ultrastructure; Retinal Degeneration / physiopathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / chemistry; Rhodopsin / genetics; Swine / embryology; Swine / genetics; Transgenes
TL;DR:
These transgenic pigs that express a mutated rhodopsin gene will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1994 article
TRANSGENIC LIVESTOCK AS GENETIC MODELS OF HUMAN-DISEASE
REPRODUCTION FERTILITY AND DEVELOPMENT, Vol. 6, pp. 643–645.
MeSH headings : Acromegaly / genetics; Animals; Animals, Genetically Modified / genetics; Eye Diseases / genetics; Genetic Diseases, Inborn / genetics; Humans; Models, Genetic; Swine
TL;DR:
In the future, livestock will play an increasingly more important role in biomedical research through the application of genetic engineering methodologies and will allow for increased sophistication of experimental design and wider use of genetically modified livestock.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1992 article
EMBRYO DEVELOPMENT INVITRO TO THE BLASTOCYST STAGE IN CATTLE, PIGS AND SHEEP
PETTERS, R. M. (1992, July). ANIMAL REPRODUCTION SCIENCE, Vol. 28, pp. 415–421.
TL;DR:
Success of embryo culture is high enough to warrant considerable optimism about further improvements in the efficiency of many embryo technologies, including nuclear transfer (cloning) and gene transfer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1990 journal article
Glucose, glutamine and inorganic phosphate in early development of the pig embryo in vitro
Journal of Reproduction & Fertility, 89(1), 269.
MeSH headings : Animals; Blastocyst / metabolism; Culture Media; Culture Techniques / methods; Embryonic and Fetal Development / physiology; Glucose / metabolism; Glutamine / metabolism; Phosphates / metabolism; Swine / physiology
TL;DR:
The greatest development was achieved with glucose and glutamine (both alone and in combination) in the media, demonstrating that an amino acid can serve as the sole energy source for complete preimplantation embryonic development in vitro.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1986 journal article
Recombinant DNA, gene transfer and the future of animal agriculture
Journal of Animal Science, 62(6), 1759.
Source: NC State University Libraries
Added: August 6, 2018
1978 journal article
FLIGHTLESS MUTATION IN WASP HABROBRACON-JUGLANDIS
JOURNAL OF HEREDITY, 69(2), 113–116.
Source: Web Of Science
Added: August 6, 2018
1977 journal article
REPRODUCTIVE-PERFORMANCE OF BRACON-HEBETOR (HYMENOPTERA-BRACONIDAE) FEMALES WITH MORE OR FEWER THAN NORMAL NUMBER OF OVARIOLES
ANNALS OF THE ENTOMOLOGICAL SOCIETY OF AMERICA, 70(4), 577–582.
TL;DR:
Wasps with fewer than 4 ovarioles produced proportionately fewer eggs than their “normal” 4-ovariole sisters, and in females with 5–9 ovariolaes, egg production did not increase significantly, suggesting the supply of vitellogenic materials is a limiting factor.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
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